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Book
Neural Signal Estimation in the Human Brain
Authors: --- ---
Year: 2016 Publisher: Frontiers Media SA

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Abstract

The ultimate goal of functional brain imaging is to provide optimal estimates of the neural signals flowing through the long-range and local pathways mediating all behavioral performance and conscious experience. In functional MRI (Magnetic Resonance Imaging), despite its impressive spatial resolution, this goal has been somewhat undermined by the fact that the fMRI response is essentially a blood-oxygenation level dependent (BOLD) signal that only indirectly reflects the nearby neural activity. The vast majority of fMRI studies restrict themselves to describing the details of these BOLD signals and deriving non-quantitative inferences about their implications for the underlying neural activity. This Frontiers Research Topic welcomed empirical and theoretical contributions that focus on the explicit relationship of non-invasive brain imaging signals to the causative neural activity. The articles presented within this resulting eBook aim to both highlight the importance and improve the non-invasive estimation of neural signals in the human brain. To achieve this aim, the following issues are targeted: (1) The spatial limitations of source localization when using MEG/EEG. (2) The coupling of the BOLD signal to neural activity. Articles discuss how animal studies are fundamental in increasing our understanding of BOLD fMRI signals, analyze how non-neuronal cell types may contribute to the modulation of cerebral blood flow, and use modeling to improve our understanding of how local field potentials are linked to the BOLD signal. (3) The contribution of excitatory and inhibitory neuronal activity to the BOLD signal. (4) Assessment of neural connectivity through the use of resting state data, computational modeling and functional Diffusion Tensor Imaging (fDTI) approaches.


Book
Neural Signal Estimation in the Human Brain
Authors: --- ---
Year: 2016 Publisher: Frontiers Media SA

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Bookmark

Abstract

The ultimate goal of functional brain imaging is to provide optimal estimates of the neural signals flowing through the long-range and local pathways mediating all behavioral performance and conscious experience. In functional MRI (Magnetic Resonance Imaging), despite its impressive spatial resolution, this goal has been somewhat undermined by the fact that the fMRI response is essentially a blood-oxygenation level dependent (BOLD) signal that only indirectly reflects the nearby neural activity. The vast majority of fMRI studies restrict themselves to describing the details of these BOLD signals and deriving non-quantitative inferences about their implications for the underlying neural activity. This Frontiers Research Topic welcomed empirical and theoretical contributions that focus on the explicit relationship of non-invasive brain imaging signals to the causative neural activity. The articles presented within this resulting eBook aim to both highlight the importance and improve the non-invasive estimation of neural signals in the human brain. To achieve this aim, the following issues are targeted: (1) The spatial limitations of source localization when using MEG/EEG. (2) The coupling of the BOLD signal to neural activity. Articles discuss how animal studies are fundamental in increasing our understanding of BOLD fMRI signals, analyze how non-neuronal cell types may contribute to the modulation of cerebral blood flow, and use modeling to improve our understanding of how local field potentials are linked to the BOLD signal. (3) The contribution of excitatory and inhibitory neuronal activity to the BOLD signal. (4) Assessment of neural connectivity through the use of resting state data, computational modeling and functional Diffusion Tensor Imaging (fDTI) approaches.


Book
Neural Signal Estimation in the Human Brain
Authors: --- ---
Year: 2016 Publisher: Frontiers Media SA

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Bookmark

Abstract

The ultimate goal of functional brain imaging is to provide optimal estimates of the neural signals flowing through the long-range and local pathways mediating all behavioral performance and conscious experience. In functional MRI (Magnetic Resonance Imaging), despite its impressive spatial resolution, this goal has been somewhat undermined by the fact that the fMRI response is essentially a blood-oxygenation level dependent (BOLD) signal that only indirectly reflects the nearby neural activity. The vast majority of fMRI studies restrict themselves to describing the details of these BOLD signals and deriving non-quantitative inferences about their implications for the underlying neural activity. This Frontiers Research Topic welcomed empirical and theoretical contributions that focus on the explicit relationship of non-invasive brain imaging signals to the causative neural activity. The articles presented within this resulting eBook aim to both highlight the importance and improve the non-invasive estimation of neural signals in the human brain. To achieve this aim, the following issues are targeted: (1) The spatial limitations of source localization when using MEG/EEG. (2) The coupling of the BOLD signal to neural activity. Articles discuss how animal studies are fundamental in increasing our understanding of BOLD fMRI signals, analyze how non-neuronal cell types may contribute to the modulation of cerebral blood flow, and use modeling to improve our understanding of how local field potentials are linked to the BOLD signal. (3) The contribution of excitatory and inhibitory neuronal activity to the BOLD signal. (4) Assessment of neural connectivity through the use of resting state data, computational modeling and functional Diffusion Tensor Imaging (fDTI) approaches.


Book
Diffusion Tensor Imaging : A Practical Handbook
Authors: --- ---
ISBN: 1493931180 1493931172 9781493931170 Year: 2016 Publisher: New York, NY : Springer New York : Imprint: Springer,

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Abstract

This book provides an overview of the practical aspects of diffusion tensor imaging (DTI), from understanding the basis of the technique through selection of the right protocols, trouble-shooting data quality, and analyzing DTI data optimally. DTI is a non-invasive magnetic resonance imaging (MRI) technique for visualizing and quantifying tissue microstructure based on diffusion. The book discusses the theoretical background underlying DTI and advanced techniques based on higher-order models and multi-shell diffusion imaging. It covers the practical implementation of DTI; derivation of information from DTI data; and a range of clinical applications, including neurosurgical planning and the assessment of brain tumors. Its practical utility is enhanced by decision schemes and a fully annotated DTI brain atlas, including color fractional anisotropy maps and 3D tractography reconstructions of major white matter fiber bundles. Featuring contributions from leading specialists in the field of DTI, Diffusion Tensor Imaging: A Practical Handbook is a valuable resource for radiologists, neuroradiologists, MRI technicians, and clinicians.

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