Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Organic Synthesis Using Biocatalysis provides a concise background on the application of biocatalysis for the synthesis of organic compounds, including the important biocatalytic reactions and application of biocatalysis for the synthesis of organic compounds in pharmaceutical and non-pharmaceutical areas. The book provides recipes for carrying out various biocatalytic reactions, helping both newcomers and non-experts use these methodologies. It is written by experts in their fields, and provides both a current status and future prospects of biocatalysis in the synthesis of organic molecules. Provides a concise background of the application of biocatalysis for the synthesis of organic compounds Expert contributors present recipes for carrying out biocatalytic reactions, including subject worthy discussions on biocatalysis in organic synthesis, biocatalysis for selective organic transformation, enzymes as catalysis for organic synthesis, biocatalysis in Industry, including pharmaceuticals, and more Contains detailed, separate chapters that describe the application of biocatalysis

Organic compounds --- Biocatalysis. --- Synthesis. --- Catalysis --- Chemistry, Organic --- Chemistry, Synthetic organic --- Organic synthesis (Chemistry) --- Synthetic organic chemistry --- Synthesis --- Biocatalysis --- Organic compounds - Synthesis

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book connects a retrosynthetic or disconnection approach with synthetic methods in the preparation of target molecules from simple, achiral ones to complex, chiral structures in the optically pure form. Retrosynthetic considerations and asymmetric syntheses are presented as closely related topics, often in the same chapter, underlining the importance of retrosynthetic consideration of target molecules neglecting stereochemistry and equipping readers to overcome the difficulties they may encounter in the planning and experimental implementation of asymmetric syntheses. This approach prepares students in advanced organic chemistry courses, and in particular young scientists working at academic and industrial laboratories, for independently solving synthetic problems and creating proposals for the synthesis of complex structures.

Biochemistry --- Chemistry --- Physical Sciences & Mathematics --- Organic compounds --- Biochemical engineering. --- Chemistry, Organic. --- Synthesis. --- Organic chemistry --- Bio-process engineering --- Bioprocess engineering --- Chemistry, Organic --- Chemistry, Synthetic organic --- Organic synthesis (Chemistry) --- Synthetic organic chemistry --- Synthesis --- Biotechnology --- Chemical engineering --- Chemical engineering. --- Organic Chemistry. --- Biochemical Engineering. --- Industrial Chemistry/Chemical Engineering. --- Chemistry, Industrial --- Engineering, Chemical --- Industrial chemistry --- Engineering --- Chemistry, Technical --- Metallurgy --- Organic chemistry.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This thesis describes the inception, design, and implementation of stereoselective desymmetrization reactions in the total synthesis of the natural products pactamycin and paspaline. In the case of pactamycin, the author develops a novel asymmetric Mannich reaction and symmetry-breaking reduction strategy to enable facile construction of the complex core architecture in fifteen steps using commercially available materials – the shortest synthesis to date. He subsequently demonstrates the flexibility of this approach in SAR investigations by highlighting the preparation of twenty-five unique pactamycin structural congeners. For paspaline, the author develops a biocatalytic desymmetrization strategy that allows the highly controlled synthesis of core stereochemistry and provides a platform for the development of new conceptual disconnections in the synthesis of "steroid-like" natural products. This thesis offers a valuable resource for students embarking on a PhD in total synthesis.

Chemistry. --- Organic chemistry. --- Chemical engineering. --- Medicinal chemistry. --- Organic Chemistry. --- Medicinal Chemistry. --- Industrial Chemistry/Chemical Engineering. --- Organic compounds --- Asymmetry (Chemistry) --- Synthesis. --- Molecular asymmetry --- Chemistry, Organic --- Chemistry, Synthetic organic --- Organic synthesis (Chemistry) --- Synthetic organic chemistry --- Synthesis --- Stereochemistry --- Chemistry, Organic. --- Biochemistry. --- Chemistry, Industrial --- Engineering, Chemical --- Industrial chemistry --- Engineering --- Chemistry, Technical --- Metallurgy --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Organic chemistry --- Composition --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry