Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy. The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.

Medicine. --- Cancer research. --- Immunology. --- Molecular biology. --- Biomedicine. --- Cancer Research. --- Molecular Medicine. --- T cells. --- Cancer --- Cellular therapy. --- Immunocompetent cells --- Immunotherapy. --- Therapeutic use. --- Immunologically competent cells --- Cell therapy --- Cells --- Therapy, Cellular --- T lymphocytes --- Thymus-dependent cells --- Thymus-dependent lymphocytes --- Thymus-derived cells --- Therapeutic use --- Immune system --- Organotherapy --- Therapeutics, Physiological --- Transplantation of organs, tissues, etc. --- Cell transplantation --- Lymphocytes --- Immunological aspects --- Treatment --- Oncology. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Immunobiology --- Serology --- Tumors --- Health Workforce --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Cancer research