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Volker H. Schmitt untersucht die Gewebereaktion auf fünf Barrierematerialien histologisch, immunhistochemisch und ultrastrukturell. Der Autor kann zeigen, dass der ultrastrukturelle Befund mit dem makroskopischen Ergebnis korreliert, die effektivste Barriere zeigte das größte Ausmaß an Remesothelialisierung. Eine bislang als negativ interpretierte Inflammation ging mit geringerer Adhäsionsbildung einher. Es gab keine Korrelation zwischen dem Vorhandensein CD68-positiver Makrophagen und der Gewebereaktion. Solche Untersuchungen der Biokompatibilität und Oberflächenmorphologie sind essentiell für die Weiterentwicklung materialbasierter Ansätze, weg von rein physikalischen Barrieren hin zu funktionalen Biomaterialien im Sinne des Tissue Engineering. Diese Untersuchung ist praxisnah und weiterführend, da durch serosale Schädigung entstehende peritoneale Adhäsionen eine häufige Komplikation in der Abdominalchirurgie darstellen. Der Inhalt Serosale Wundheilung, Pathogenese peritonealer Adhäsionen, präventive Strategien Materialbedingte Gewebereaktion Rolle CD68-positiver Makrophagen Ultrastrukturelle Materialevaluation Die Zielgruppen Dozierende und Studierende sowie Praktiker der Pathologie, Chirurgie, Gynäkologie und Materialwissenschaften Der Autor Volker H. Schmitt war wissenschaftlicher Mitarbeiter am Institut für Pathologie der Universitätsmedizin Mainz. Derzeit ist er Arzt in Weiterbildung am Zentrum für Kardiologie der Johannes Gutenberg-Universität Mainz mit Forschungstätigkeit in vaskulärer Biologie und Epidemiologie.

Pathology. --- Biomaterials. --- Surgery.

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Biomedical materials --- Biocompatible materials --- Biomaterials --- Medical materials --- Medicine --- Biomedical engineering --- Materials --- Biocompatibility --- Prosthesis --- Bioartificial materials --- Hemocompatible materials --- Biomaterials (Biomedical materials)

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Biomedical materials. --- Lasers --- Industrial applications. --- Biocompatible materials --- Biomaterials --- Medical materials --- Medicine --- Biomedical engineering --- Materials --- Biocompatibility --- Prosthesis --- Bioartificial materials --- Hemocompatible materials --- Biomaterials (Biomedical materials)

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The proceedings of the workshop "Advanced Materials for Technical and Medical Purpose" (AMTMP-2016 was organized by Institute of High Technology Physics and held on February 15-17, 2016 in Tomsk Polytechnic University, Tomsk, Russia) covers the research works and technologies aimed at the treatment of materials and deposition of coatings, design of new-generation composites, additive manufacturing of metallic and non-metallic articles, materials for biomedical application . The workshop was targeted at sharing of opinions and discussion the problems existing in the areas and ways of their solution. Additive technologies, materials, multiscale composites, coatings, nanotechnology, numerical simulation, discharge and plasma-beam technology, biomedicine materials science.

Materials science --- Materials science. --- Biomedical materials. --- Biocompatible materials --- Biomaterials --- Medical materials --- Medicine --- Biomedical engineering --- Materials --- Biocompatibility --- Prosthesis --- Material science --- Physical sciences --- Bioartificial materials --- Hemocompatible materials --- Biomaterials (Biomedical materials)

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Tissue engineering is an innovative, multidisciplinary approach which combines (bio)materials, cells and growth factors with the aim to obtain neo-organogenesis to repair or replenish damaged tissues and organs. The generation of engineered tissues and organs (e. g. skin and bladder) has entered into the clinical practice in response to the chronic lack of organ donors. In particular, for the skeletal and cardiac muscles the translational potential of tissue engineering approaches has clearly been shown, even though the construction of this tissue lags behind others given the hierarchical, highly organized architecture of striated muscles. Cardiovascular disease is the leading cause of death in the developed world, where the yearly incidence of Acute MI (AMI) is approx 2 million cases in Europe. Recovery from AMI and reperfusion is still less than ideal. Stem cell therapy may represent a valid treatment. However, delivery of stem cells alone to infarcted myocardium provides no structural support while the myocardium heals, and the injected stem cells do not properly integrate into the myocardium because they are not subjected to the mechanical forces that are known to drive myocardial cellular physiology. On the other hand, there are many clinical cases where the loss of skeletal muscle due to a traumatic injury, an aggressive tumour or prolonged denervation may be cured by the regeneration of this tissue. In vivo, stem or progenitor cells are sheltered in a specialized microenvironment (niche), which regulates their survival, proliferation and differentiation. The goal of this research topic is to highlight the available knowledge on biomaterials and bioactive molecules or a combination of them, which can be used successfully to differentiate stem or progenitor cells into beating cardiomyocytes or organized skeletal muscle in vivo. Innovations compared to the on-going trials may be: 1) the successful delivery of stem cells using sutural scaffolds instead of intracoronary or intramuscular injections; 2) protocols to use a limited number of autologous or allogeneic stem cells; 3) methods to drive their differentiation by modifying the chemical-physical properties of scaffolds or biomaterials, incorporating small molecules (i.e. miRNA) or growth factors; 4) methods to tailor the scaffolds to the elastic properties of the muscle; 5) studies which suggest how to realize scaffolds that optimize tissue functional integration, through the combination of the most up-to-date manufacturing technologies and use of bio-polymers with customized degradation properties.

Angiogenesis --- Scaffold --- cardiac stem cells --- skeletal muscle --- Biomaterials --- Tissue Engineering --- satellite cells --- Angiogenesis --- Scaffold --- cardiac stem cells --- skeletal muscle --- Biomaterials --- Tissue Engineering --- satellite cells