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This thorough volume delves into antiepileptic drug discovery with a comprehensive collection of innovative approaches for the development of antiepileptic therapies, focusing on novel molecular targets for antiepileptic drugs, computer-aided approaches for the identification of new drug candidates, and therapeutic strategies to overcome refractory epilepsy. The last section illustrates the potential benefits that network pharmacology and rational drug repurposing could bring to the antiepileptic drug discovery community. Written for the Methods in Pharmacology and Toxicology series, chapters include the kind of detailed description and implementation advice to ensure results in the laboratory. Authoritative and practical, Antiepileptic Drug Discovery: Novel Approaches aims to provide medicinal chemists, pharmacologists, and other researchers with the tools need to further explore the study of pharmacoresistant epilepsy and the discovery of new antiepileptic drugs.

Toxicology. --- Pharmacology/Toxicology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Anticonvulsius --- Biologia molecular --- Biofísica molecular --- Bioquímica molecular --- Biofísica --- Bioquímica --- Histoquímica --- Biologia molecular vegetal --- Codi genètic --- Diagnòstic molecular --- Endocrinologia molecular --- Evolució molecular --- Farmacologia molecular --- Genètica molecular --- Glicòmica --- Metabolòmica --- Microbiologia molecular --- Neurobiologia molecular --- Patologia molecular --- Proteòmica --- Reconeixement molecular --- Biomolècules --- Antiepilèptics --- Agents antiepilèptics --- Medicaments anticonvulsius --- Relaxants musculars

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A description of our current understanding of antiepileptic drug use during pregnancy, this book includes chapters on the impact of seizures on the mother and developing child, changes in maternal physiology during pregnancy and its impact on drug disposition, and the pharmacokinetic differences between the various anti-seizure medications. It also deals with the possible harmful effects of antiepileptic drug exposure during pregnancy on the physical and intellectual development of the fetus. Clinicians have to balance the potential adverse effects of the medicine for the fetus and mother-to-be against the risks that uncontrolled seizures hold for both when treating pregnant women with antiepileptic drugs. Only recently have enough scientific data emerged to provide a rational basis for treatment decisions that take in both aspects. This work provides a single, accessible, and up-to-date resource for busy clinicians.

Medical Professional Practice --- Medicine --- Health & Biological Sciences --- Anticonvulsants. --- Obstetrical pharmacology. --- Epilepsy in pregnancy. --- Anti-epileptic drugs --- Anticonvulsant drugs --- Antiepileptic agents --- Antiepileptics --- Pregnancy --- Obstetrics --- Pharmacology --- Central nervous system depressants --- Muscle relaxants --- Convulsions --- Complications --- Chemotherapy --- Family medicine. --- Obstetrics. --- Maternal and infant welfare. --- Neurology. --- General Practice / Family Medicine. --- Obstetrics/Perinatology/Midwifery. --- Maternal and Child Health. --- Maternal-fetal medicine --- Family practice (Medicine) --- General practice (Medicine) --- Physicians (General practice) --- Nervous system --- Neuropsychiatry --- Infant welfare --- Infants --- Maternity welfare --- Child welfare --- Mothers --- Women --- Maternal health services --- Diseases --- Charities, protection, etc. --- Charities --- General practice (Medicine). --- Maternal and child health services. --- Neurology . --- Family medicine