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Animal Welfare. --- Animals, Laboratory. --- Anesthetics --- Behavior, Animal --- Animaux --- Animaux de laboratoire --- Anesthésiques --- administration and dosage. --- drug effects. --- Protection --- Pharmacocinétique --- Animaux de laboratoire. --- Protection. --- Pharmacocinétique. --- Animal Welfare --- Animals, Laboratory --- Anesthésiques --- Pharmacocinétique.

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This volume provides a comprehensive collection of protocols on new technology across various model organisms.  Chapters describe species-specific methods to generate new mutants the content is completed by chapters on natural TAL effectors, TAL element DNA binding principles, TALEN target site prediction, and methods for the efficient construction of TALEN coding regions. While addition chapter focus on the application of TALEN as sequence-specific nucleases and TAL based gene activators or inhibitors and the visualization of chromatin dynamics in live cells.  Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.   Authoritative and cutting-edge, TALENs: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Human genetics. --- Animal genetics. --- Laboratory animals. --- Human Genetics. --- Animal Genetics and Genomics. --- Animal Models. --- Animals, Experimental --- Animals, Laboratory --- Animals in research --- Experimental animals --- Lab animals --- Animal culture --- Laboratory organisms --- Working animals --- Animal experimentation --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology

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Schizophrenia --- Psychology, Pathological --- Physiological aspects --- Abnormal psychology --- Diseases, Mental --- Mental diseases --- Mental disorders --- Pathological psychology --- Psychology, Abnormal --- Psychopathology --- Neurology --- Brain --- Criminal psychology --- Mental health --- Psychiatry --- Psychoanalysis --- Dementia praecox --- Schizophrenic disorders --- Psychoses --- Schizotypal personality disorder --- Diseases --- Schizophrenia. --- Disease Models, Animal. --- Animal Disease Model --- Animal Disease Models --- Disease Model, Animal --- Animals, Laboratory --- Models, Biological --- Dementia Praecox --- Schizophrenic Disorders --- Disorder, Schizophrenic --- Disorders, Schizophrenic --- Schizophrenias --- Schizophrenic Disorder

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This book is a methodological source on mice models of vascular diseases. Covering various areas, each chapter is written by a pioneering researcher who has developed an original vascular disease model. Notoriously difficult to reproduce, each model is described in detail and numerous photographs are provided with links to videos. Genetically modified mice are a very powerful tool for studying the pathogenesis of various diseases, including immunological and oncological disorders, but they had always been thought to be too small to be used in the field of cardiovascular disease. Recently, however, various mice models of vascular diseases have been reported, and these will make a substantial contribution to basic research on cardiovascular and metabolic disorders. .

Cardiovascular Diseases --- Medicine --- Health & Biological Sciences --- Blood-vessels --- Diseases. --- Research. --- Biomedical research --- Medical research --- Angiology --- Vascular diseases --- Cardiology. --- Metabolic diseases. --- Laboratory animals. --- Metabolic Diseases. --- Animal Models. --- Animals, Experimental --- Animals, Laboratory --- Animals in research --- Experimental animals --- Lab animals --- Animal culture --- Laboratory organisms --- Working animals --- Animal experimentation --- Disorders of metabolism --- Metabolic diseases --- Metabolic disorders --- Metabolism, Disorders of --- Diseases --- Heart --- Internal medicine --- Animal models in research. --- Biological models --- Laboratory animals --- Research

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This book presents results obtained from the whole mount preparations, radiological, and histological studies of 60 pu/pu and pu/+ mice from late embryo until 3 months of age. Most mice were in the embryo to 6 week age group where vertebral developmental changes are most marked. Although vertebral abnormalities have been identified as due to mutations in the delta-like 3 (Dll3) gene, it is evident that each mouse has differing structural abnormalities. The disorder is analogous to human congenital scoliosis, a common variant of which is spondylocostal dysplasia. The histological studies presented in this book include plastic embedded sections which allow for high level resolution not only of vertebrae, intervertebral discs, and ribs but also of associated spinal cord, nerve roots and ganglia. In addition an overview of embryo and neonatal development in mouse, chick and human vertebrae is provided to better assess how and where deviant pathoanatomy occurs. The book discusses the possible variables involved in creating final deformity beyond the gene abnormality itself.

Medicine. --- Human genetics. --- Animal anatomy. --- Animal models in research. --- Biomedicine. --- Human Genetics. --- Animal Anatomy / Morphology / Histology. --- Animal Models. --- Spine --- Mice --- Abnormalities. --- Abnormities and deformities --- Posture disorders --- Morphology (Animals). --- Laboratory animals. --- Animal morphology --- Animals --- Body form in animals --- Zoology --- Morphology --- Animals, Experimental --- Animals, Laboratory --- Animals in research --- Experimental animals --- Lab animals --- Animal culture --- Laboratory organisms --- Working animals --- Animal experimentation --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Biological models --- Laboratory animals --- Research --- Animal anatomy --- Biology --- Physiology --- Anatomy --- Medical genetics. --- Anatomy, Comparative. --- Medical Genetics. --- Animal Anatomy. --- Experimental Organisms. --- Technique. --- Comparative anatomy --- Comparative morphology --- Zootomy --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Medical sciences --- Pathology --- Genetic disorders --- Genetic aspects