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Studies in human patients and animal models of disease suggest a strong correlation between defects in dendrite development and common neurological disorders such as autism. Much of this book is thus dedicated toward highlighting recent advances in our understanding of the cellular and molecular mechanisms that regulate the development and maintenance of dendrites, a crucial component of neurons. The book begins by presenting the current state of knowledge on the building blocks or cell biology of dendrites. Mechanisms that sculpt the stereotypic architecture of dendritic arbors and shape their connectivity are also discussed, along with recent work describing how dendritic organization and connectivity are perturbed in disease. A unique aspect of the book is its exploration of diverse neuronal cell types across vertebrates and invertebrates, allowing a comparison of mechanisms across distinct circuits and species. The book comprises six parts, which cover the major advances in the field: Part 1, Introduction; Part 2, Basic Biology of Dendrites; Part 3, Patterning Dendritic Architecture of Neurons and Their Populations; Part 4, Cellular and Molecular Control of Dendrite Development and Maintenance; Part 5, Synapse Formation onto Dendrites; and Part 6, Dendrites in Disease. The book offers an excellent point of entry for students interested in neuroscience, as well as for clinicians.

Medicine. --- Neurosciences. --- Neurology. --- Animal models in research. --- Biomedicine. --- Animal Models. --- Dendrites --- Diseases. --- Neurons --- Laboratory animals. --- Animals, Experimental --- Animals, Laboratory --- Animals in research --- Experimental animals --- Lab animals --- Animal culture --- Laboratory organisms --- Working animals --- Animal experimentation --- Medicine --- Nervous system --- Neuropsychiatry --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Diseases --- Neurology . --- Biological models --- Laboratory animals --- Research

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Laboratory animals. --- Animal anesthesia. --- Anesthesia in animals --- Anesthetics for animals --- Anesthesia --- Animal immobilization --- Animals, Experimental --- Animals, Laboratory --- Animals in research --- Experimental animals --- Lab animals --- Animal culture --- Laboratory organisms --- Working animals --- Animal experimentation --- Animals, Laboratory. --- Anesthésie en médecine vétérinaire. --- Animaux de laboratoire. --- veterinary. --- veterinary

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This book is a methodological source on mice models of vascular diseases. Covering various areas, each chapter is written by a pioneering researcher who has developed an original vascular disease model. Notoriously difficult to reproduce, each model is described in detail and numerous photographs are provided with links to videos. Genetically modified mice are a very powerful tool for studying the pathogenesis of various diseases, including immunological and oncological disorders, but they had always been thought to be too small to be used in the field of cardiovascular disease. Recently, however, various mice models of vascular diseases have been reported, and these will make a substantial contribution to basic research on cardiovascular and metabolic disorders. .

Cardiovascular Diseases --- Medicine --- Health & Biological Sciences --- Blood-vessels --- Diseases. --- Research. --- Biomedical research --- Medical research --- Angiology --- Vascular diseases --- Cardiology. --- Metabolic diseases. --- Laboratory animals. --- Metabolic Diseases. --- Animal Models. --- Animals, Experimental --- Animals, Laboratory --- Animals in research --- Experimental animals --- Lab animals --- Animal culture --- Laboratory organisms --- Working animals --- Animal experimentation --- Disorders of metabolism --- Metabolic diseases --- Metabolic disorders --- Metabolism, Disorders of --- Diseases --- Heart --- Internal medicine --- Animal models in research. --- Biological models --- Laboratory animals --- Research --- Metabolism --- Disorders.

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This book presents results obtained from the whole mount preparations, radiological, and histological studies of 60 pu/pu and pu/+ mice from late embryo until 3 months of age. Most mice were in the embryo to 6 week age group where vertebral developmental changes are most marked. Although vertebral abnormalities have been identified as due to mutations in the delta-like 3 (Dll3) gene, it is evident that each mouse has differing structural abnormalities. The disorder is analogous to human congenital scoliosis, a common variant of which is spondylocostal dysplasia. The histological studies presented in this book include plastic embedded sections which allow for high level resolution not only of vertebrae, intervertebral discs, and ribs but also of associated spinal cord, nerve roots and ganglia. In addition an overview of embryo and neonatal development in mouse, chick and human vertebrae is provided to better assess how and where deviant pathoanatomy occurs. The book discusses the possible variables involved in creating final deformity beyond the gene abnormality itself.

Medicine. --- Human genetics. --- Animal anatomy. --- Animal models in research. --- Biomedicine. --- Human Genetics. --- Animal Anatomy / Morphology / Histology. --- Animal Models. --- Spine --- Mice --- Abnormalities. --- Abnormities and deformities --- Posture disorders --- Morphology (Animals). --- Laboratory animals. --- Animal morphology --- Animals --- Body form in animals --- Zoology --- Morphology --- Animals, Experimental --- Animals, Laboratory --- Animals in research --- Experimental animals --- Lab animals --- Animal culture --- Laboratory organisms --- Working animals --- Animal experimentation --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Biological models --- Laboratory animals --- Research --- Animal anatomy --- Biology --- Physiology --- Anatomy --- Medical genetics. --- Anatomy, Comparative. --- Medical Genetics. --- Animal Anatomy. --- Experimental Organisms. --- Technique. --- Comparative anatomy --- Comparative morphology --- Zootomy --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Medical sciences --- Pathology --- Genetic disorders --- Genetic aspects

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The present book addresses the multi-disciplinary nature of Translational Outcomes Research, which is a watershed for nearly all the disciplines of Life and Health Sciences, along with the Materials Sciences including but not limited to Zoology, Botany, Microbiology, Biochemistry, Physiology, Nanotechnology, the Medical Sciences, Bioengineering, Biophysics, Medicinal Chemistry, Structural Biology, Biostatistics and Bioinformatics. This book, for the first time, addresses the basic premises of fundamental research in facilitating drug discovery. One chapter is dedicated to a novel generation of platforms with novel camelid antibodies and their technological extensions, while another focuses on functional food and nutraceuticals. The book begins with a thorough overview of what translational outcomes research connotes and what the current status of research in the area is, and goes on to elucidate various pertinent preclinical disease models and their uses in basic and application based research in the Life Sciences. How basic approaches to screening and characterization vis-à-vis their role in amelioration of the two cardinal problems of inflammation and degeneration involved in most diseases is elucidated. The book ends with a discussion of the relevance and importance of using Bio Green technology in Translational Outcomes, addressing the need to fill the gap between academia and industry and clinics that can arise through direct or indirect collaboration between the stakeholders and emphasizing the need for an eco-friendly approach so as not to jeopardize the fine balance that holds life on earth in harmony.

Life sciences. --- Gene therapy. --- Antibodies. --- Molecular biology. --- Regenerative medicine. --- Tissue engineering. --- Animal models in research. --- Life Sciences. --- Regenerative Medicine/Tissue Engineering. --- Molecular Medicine. --- Gene Therapy. --- Animal Models. --- Life sciences --- Medicine --- Research. --- Biomedical research --- Medical research --- Biosciences --- Sciences, Life --- Science --- Medicine. --- Monoclonal antibodies. --- Laboratory animals. --- Animals, Experimental --- Animals, Laboratory --- Animals in research --- Experimental animals --- Lab animals --- Animal culture --- Laboratory organisms --- Working animals --- Animal experimentation --- Antibodies, Monoclonal --- Monoclonal immunoglobulins --- Immunoglobulins --- Molecular cloning --- Therapy, Gene --- Genetic engineering --- Therapeutics --- Clinical sciences --- Medical profession --- Human biology --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Biological models --- Laboratory animals --- Research --- Antibodies --- Immune globulins --- Immune serum globulin --- Blood proteins --- Globulins --- Plasma cells --- Antibody diversity --- Antigens --- Bacterial immunoglobulin-binding proteins --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Biomedical engineering --- Regenerative medicine --- Tissue culture --- Regeneration (Biology)