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This volume contains a collection of writings from the leaders in the fields of Molecular Biology and Melanoma Research which will begin to tell the ever-expanding story of the most recent findings, discoveries, and potential of BRAF-directed targets in melanoma. Recent research has shown that BRAF inhibitors are effective for a short period of time, but there is little hope that these drugs as single agents will lead to durable benefit in a majority of patients. Among scientists and researchers who work in drug discovery, there is a lot of interest in the development of molecularly targeted cancer agents. Namely, the identification of a molecular target, the selection of molecules which effectively inhibit this target. What is starkly different about the development of this class of compounds, however, is that the mechanism of action of these agents are not as straightforward as was once previously assumed and the mechanisms of resistance that tumor cells employ to evade complete destruction are unlike any that have been described before. These discoveries in addition to utilization of modern molecular biology techniques have led to a series of hypotheses regarding which other types of molecules could be used in combination with BRAF-inhibitors in hopes of revolutionizing the potential of therapeutics in melanoma.

Biomedicine. --- Cancer Research. --- Molecular Medicine. --- Medical Microbiology. --- Pharmacology/Toxicology. --- Medicine. --- Oncology. --- Microbiology. --- Toxicology. --- Médecine --- Cancérologie --- Microbiologie --- Toxicologie --- Melanoma --- raf Kinases --- Enzyme Inhibitors --- Therapeutics --- Neuroendocrine Tumors --- Nevi and Melanomas --- Biology --- Investigative Techniques --- Biological Science Disciplines --- Molecular Mechanisms of Pharmacological Action --- Proto-Oncogene Proteins --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Neuroectodermal Tumors --- MAP Kinase Kinase Kinases --- Neoplasms by Histologic Type --- Neoplasms, Germ Cell and Embryonal --- Pharmacologic Actions --- Intracellular Signaling Peptides and Proteins --- Protein-Serine-Threonine Kinases --- Neoplasms, Nerve Tissue --- Oncogene Proteins --- Natural Science Disciplines --- Neoplasms --- Protein Kinases --- Neoplasm Proteins --- Chemical Actions and Uses --- Diseases --- Peptides --- Proteins --- Disciplines and Occupations --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Phosphotransferases (Alcohol Group Acceptor) --- Phosphotransferases --- Transferases --- Enzymes --- Enzymes and Coenzymes --- Molecular Targeted Therapy --- Drug Therapy --- Proto-Oncogene Proteins B-raf --- Genetics --- Protein Kinase Inhibitors --- Methods --- Medicine --- Health & Biological Sciences --- Oncology --- Drug delivery systems. --- Treatment. --- Delivery systems, Drug --- Drug administration technology --- Drug delivery technology --- Drugs --- Malignant melanoma --- Melanocytic tumor --- Delivery systems --- Cancer research. --- Medical microbiology. --- Molecular biology. --- Pharmacology. --- Pharmaceutical technology --- Cancer --- Neuroendocrine tumors --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Microbial biology --- Microorganisms --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Tumors --- Toxicology --- Health Workforce --- Drug effects --- Medical pharmacology --- Chemotherapy --- Pharmacy --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Cancer research --- Physiological effect