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This case based resource focuses on kidney disease in patients with cancer. Chapters cover the pathophysiology and management of specific kidney diseases in cancer patients, as well as the impact of chemotherapy, toxicity of organ and stem cell transplantation and other emerging therapies. Filling a significant knowledge gap in this burgeoning field, Onconephrology features the latest evidence and clinical approaches for the beginner or experienced practitioner. .

Medicine & Public Health. --- Nephrology. --- Oncology. --- Medicine. --- Médecine --- Néphrologie --- Cancérologie --- Kidneys -- Cancer -- Chemotherapy. --- Kidneys -- Cancer. --- Urology & Nephrology --- Medicine --- Health & Biological Sciences --- Kidneys --- Cancer. --- Cancer --- Chemotherapy. --- Oncology  . --- Tumors --- Internal medicine

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Make optimal use of the latest personalized therapeutic strategies with Handbook of Targeted Cancer Therapy! This concise, practical oncology reference examines more than 120 targeted therapy agents for which clinical trial data are available, and explains when and how you can use them to most effectively combat cancer. Approach clinical challenges from any direction with separate sections on Targets by Organ Site, Carcinogenesis from the Perspective of Targeted Therapy, Molecular Targets and Pathways, and Targeted Therapy Agents; find information easily thanks to a color-coded format and an intuitive organization; access the complete contents online and on mobile devices, with regular updates to include newly approved treatments and important state of the art cancer information for caregivers, researchers, other health care professionals, and even patients.Now with the print edition, enjoy the bundled interactive eBook edition, offering tablet, smartphone, or online access to: complete content with enhanced navigation; a powerful search tool that pulls results from content in the book, your notes, and even the web; cross-linked pages, references, and more for easy navigation; highlighting tool for easier reference of key content throughout the text; ability to take and share notes with friends and colleagues and quick-reference tabbing to save your favorite content for future use.

Cancer --- Drug targeting. --- Cancer therapy --- Cancer treatment --- Drugs --- Site-specific drug delivery --- Targeting of drugs --- Target organs (Anatomy) --- Antineoplastic agents --- Chemotherapy. --- Treatment. --- Therapy --- Targeting --- Dosage forms --- Treatment --- Cancer Chemotherapy.

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The field of protein kinases has greatly impacted our understanding of the basic mechanisms in cell function. The field has also been a major focus of drug development that considers the broad reach of the protein kinase function under diverse conditions. One member of the kinome, protein kinase CK2, continues to emerge as a major signaling molecule involved in diverse functions in health and disease. This kinase has unique features, most notably its ubiquitous and highly conserved nature. Its vast number of potential substrates exemplifies its involvement in various functions in cells under both the normal and diseased states. Of particular note is the observation that due to its ubiquitous nature, CK2 has been found to be dysregulated in all cancers that have been examined. As such, it is now being considered a potentially important target for cancer therapy. Protein Kinase CK2 plays equally important functions in development and intracellular activities, and has a global impact on cell growth and proliferation. An additional key function of CK2 is the impact of its activity on cell death processes. Given the vast nature of its functions, CK2 has been proposed to serve as a “master regulator” of cell function. The chapters included in this work cover a wide range of topics dealing with some of the functions mentioned above, providing an important starting point for research investigators and graduate students interested in this field.

Biomedicine. --- Cancer Research. --- Protein Science. --- Apoptosis. --- Medicine. --- Oncology. --- Biochemistry. --- Cytology. --- Médecine --- Cancérologie --- Biochimie --- Cytologie --- Cancer -- Chemotherapy. --- Mouse leukemia complex -- Chemotherapy. --- Protein kinase CK2. --- Medicine --- Health & Biological Sciences --- Oncology --- Casein kinase 2 --- Casein kinase II --- Protein kinase CKII --- Cancer research. --- Proteins. --- Protein kinases --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Tumors --- Composition --- Proteins . --- Cell death --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Cancer research