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Quatrième de couverture : "La Vitamine D est l'objet d'une véritable effervescence depuis quelques années parmi les médecins et les biologistes. Il suffit de lancer une quête informatique pour constater l'augmentation exponentielle du nombre d'articles publiés chaque semaine sur le sujet. Le propre de cet ouvrage -coordonné justement par un médecin et un biologiste- est bien d'aborder ces deux aspects. D'une part ils ont veillé à présenter les aspects pratiques utiles à l'exercice médical, en s'appuyant sur les études et méta-analyses disponibles, ainsi que sur les Recommandations des Sociétés nationales et internationales. D'autre part, ils ont exposé les acquisitions fondamentales les plus récentes, et le lecteur constatera qu'il y en a plusieurs. Enfin à la frontière de la clinique et de la biologie, plusieurs questions se trouvent posées sur les effets extra-osseux de la vitamine D, et là aussi, la participation des auteurs francophones les plus habilités permettra d'accéder à l'état de l'art actuel. Voici donc, sous l'égide du GRIO (Groupe de Recherche et d'Information sur les Ostéoporoses), les grandes lignes qui ont présidé à la rédaction de cet ouvrage : des pistes claires pour la pratique médicale, mais sans simplification excessive, et en fondant le raisonnement sur les données les plus actuelles de la Science."
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A balanced regulation of bone formation and resorption in the healthy individual is required for a healthy bone. On the other side, there are many factors which can lead to alterations in bone density and microarchitecture. Menopause is a condition which can increase the remodeling process in favor of resorption. Moreover, there are also some diseases, i.e. chronic kidney bone disease, that increase the possibility of fractures and the subsequent disability leading to increased mortality. However, it is clear that drugs are an essential element of the therapy and this issue is analyzed extensively in this book. Some novel pathophysiological mechanisms are also presented, offering advanced knowledge to the reader. The book includes chapters from scientific departments and researchers from all over the world.
Osteoporosis. --- Bones --- Vitamin D deficiency --- Diseases --- Immunology
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Rising awareness about the potential link between vitamin D deficiency and adverse health outcomes has seen an increase in the rate of vitamin D testing in developed countries. The cost of a single vitamin D test is moderate (e.g., $61.32 in British Colombia) but the elevated testing rate contributes to substantial healthcare costs. Concern over rising costs led to reform in testing coverage in 2010 in Ontario, followed by other provinces. The changes in Ontario were based on a 2010 report by the Ontario Health Technology Advisory Committee (OHTAC) on the clinical utility of vitamin D testing (reviewed in this report). Despite a lack of direct evidence on testing, a recommendation was made against providing testing for the general population. Tests are now indicated only for individuals with specific conditions (i.e., osteoporosis, rickets, osteomalacia, malabsorption syndromes, renal disease, and individuals taking medications that may affect vitamin D status). The Endocrine Society and Osteoporosis Canada also recommend against screening for low risk individuals. There is a lack of evidence to suggest that the rise in test frequency has translated into improved healthcare practices. For example, the temporal increase in testing in Australia has not resulted in improved osteoporosis detection in women aged 45 to 74. There is also a lack of evidence on the cost-effectiveness of testing. In light of the rise in test frequency, assay and cut-off inconsistency, and the lack of evidence for the utility of testing, this report will investigate the clinical and cost-effectiveness of testing in the general population.
Vitamin D Deficiency --- Vitamin D Deficiency --- Vitamin D --- Diagnostic Techniques and Procedures --- Cost-Benefit Analysis --- diagnosis. --- economics. --- analysis. --- economics. --- Canada
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Rising awareness about the potential link between vitamin D deficiency and adverse health outcomes has seen an increase in the rate of vitamin D testing in developed countries. The cost of a single vitamin D test is moderate (e.g., $61.32 in British Colombia) but the elevated testing rate contributes to substantial healthcare costs. Concern over rising costs led to reform in testing coverage in 2010 in Ontario, followed by other provinces. The changes in Ontario were based on a 2010 report by the Ontario Health Technology Advisory Committee (OHTAC) on the clinical utility of vitamin D testing (reviewed in this report). Despite a lack of direct evidence on testing, a recommendation was made against providing testing for the general population. Tests are now indicated only for individuals with specific conditions (i.e., osteoporosis, rickets, osteomalacia, malabsorption syndromes, renal disease, and individuals taking medications that may affect vitamin D status). The Endocrine Society and Osteoporosis Canada also recommend against screening for low risk individuals. There is a lack of evidence to suggest that the rise in test frequency has translated into improved healthcare practices. For example, the temporal increase in testing in Australia has not resulted in improved osteoporosis detection in women aged 45 to 74. There is also a lack of evidence on the cost-effectiveness of testing. In light of the rise in test frequency, assay and cut-off inconsistency, and the lack of evidence for the utility of testing, this report will investigate the clinical and cost-effectiveness of testing in the general population.
Vitamin D Deficiency --- Vitamin D Deficiency --- Vitamin D --- Diagnostic Techniques and Procedures --- Cost-Benefit Analysis --- diagnosis. --- economics. --- analysis. --- economics. --- Canada
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Quatrième de couverture : "Cet ouvrage propose une synthèse complète des connaissances et des travaux actuels relatifs à la vitamine D en abordant :● ses origines, son métabolisme et son mode d'action, en particulier sur les cellules osseuses, l'intestin, le rein et les parathyroïdes, mais aussi ses effets sur la différenciation et la prolifération cellulaires, le système immunitaire, le système cardiovasculaire, le système nerveux et la fonction musculaire ;● ses effets sur la santé, en étudiant notamment les relations entre le statut vitaminique D et l'incidence ou l'évolution défavorable de certaines maladies telles les maladies cardiovasculaires et métaboliques, le diabète de type II, les maladies auto-immunes ou à composante auto-immune, le cancer, les néphropathies, les maladies neurodégénératives, certaines infections, les complications de la grossesse, etc. ;● son utilisation à des fins préventives et curatives sous forme de supplémentation médicamenteuse ou de recommandations nutritionnelles.L'objectif de cet ouvrage est d'apporter aux professionnels de santé (pharmaciens, médecins généralistes, nutritionnistes et diététiciens...) tous les savoirs et outils utiles à leur pratique quotidienne."
Vitamin D --- Vitamin D. --- Vitamin D Deficiency. --- Vitamines D --- Carence en vitamines D --- metabolism --- Métabolisme --- metabolism. --- Vitamines D. --- Carence en vitamines D. --- Métabolisme.
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Osteonecrosis of the jaws is a well-known side-effect of antiresorptive therapy that predominantly occurs in patients suffering from malignant diseases and receiving intravenous administrations of nitrogen-containing bisphosphonates or subcutaneous administrations of denosumab, a monoclonal antibody. Less frequently it may also be observed in patients with osteoporosis who are being treated with these antiresorptive drugs. This textbook provides detailed, up-to-date information on all aspects of medication-related osteonecrosis of the jaws, including clinical features, pathogenesis, treatment options, and preventive measures. It also explains safe prevention and treatment strategies for patients receiving antiresorptive drugs who require extractions, implant insertions, and other dento-alveolar surgeries. This book will be of major interest for medical and dental students, dentists, and oral and maxillofacial surgeons as well as osteologists and oncologists.
Medicine & Public Health. --- Oral and Maxillofacial Surgery. --- Dentistry. --- Medicine. --- Surgery. --- Médecine --- Dentisterie --- Chirurgie --- Dentistry --- Health & Biological Sciences --- Oral Surgery --- Jaws --- Osteoporosis --- Necrosis. --- Chemotherapy --- Complications. --- Phossy jaw --- Oral surgery. --- Maxillofacial surgery. --- Bones --- Vitamin D deficiency --- Diseases --- Surgery, Primitive --- Medicine --- Dental surgery --- Odontology --- Surgery, Dental --- Oral medicine --- Teeth --- Oral surgery --- Surgery, Oral --- Oral surgeons
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