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The book focuses on the aqueous interface of biomolecules, a vital yet overlooked area of biophysical research. Most biological phenomena cannot be fully understood at the molecular level without considering interfacial behavior. The author presents conceptual advances in molecular biophysics that herald the advent of a new discipline, epistructural biology, centered on the interactions of water and biomolecular structures across the interface. The author introduces powerful theoretical and computational resources in order to address fundamental topics such as protein folding, the physico-chemical basis of enzyme catalysis and protein associations. On the basis of this information, a multi-disciplinary approach is used to engineer therapeutic drugs and to allow substantive advances in targeted molecular medicine. This book will be of interest to scientists, students and practitioners in the fields of chemistry, biophysics and biomedical engineering.

Life Sciences. --- Protein-Ligand Interactions. --- Membrane Biology. --- Molecular Medicine. --- Pharmaceutical Sciences/Technology. --- Biophysics and Biological Physics. --- Life sciences. --- Medicine. --- Pharmaceutical technology. --- RNA-ligand interactions. --- Cell membranes. --- Sciences de la vie --- Médecine --- Techniques pharmaceutiques --- Membrane cellulaire --- Antigens, Surface --- Membrane Glycoproteins --- Drug Therapy --- Drug Discovery --- Cell Physiological Processes --- Proteins --- Glycoproteins --- Chemistry, Pharmaceutical --- Amino Acids, Peptides, and Proteins --- Antigens --- Investigative Techniques --- Therapeutics --- Cell Physiological Phenomena --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Chemistry --- Chemicals and Drugs --- Pharmacology --- Biological Factors --- Phenomena and Processes --- Natural Science Disciplines --- Biological Science Disciplines --- Disciplines and Occupations --- Cell Adhesion Molecules --- Drug Design --- Cell Adhesion --- Drug Delivery Systems --- Membrane Proteins --- Physical Sciences & Mathematics --- Biochemistry --- Integral Membrane Protein --- Membrane Protein --- Membrane-Associated Proteins --- Cell Membrane Proteins --- Cell Surface Proteins --- Integral Membrane Proteins --- Surface Proteins --- Membrane Associated Proteins --- Membrane Protein, Integral --- Membrane Proteins, Integral --- Protein, Integral Membrane --- Protein, Membrane --- Proteins, Cell Membrane --- Proteins, Cell Surface --- Proteins, Integral Membrane --- Proteins, Membrane --- Proteins, Membrane-Associated --- Proteins, Surface --- Drug Targeting --- Delivery System, Drug --- Delivery Systems, Drug --- Drug Delivery System --- Drug Targetings --- System, Drug Delivery --- Systems, Drug Delivery --- Targeting, Drug --- Targetings, Drug --- Adhesion, Cell --- Adhesions, Cell --- Cell Adhesions --- Drug Modeling --- Design, Drug --- Designs, Drug --- Drug Designs --- Drug Modelings --- Modeling, Drug --- Modelings, Drug --- Saccharide Mediated Cell Adhesion Molecules --- Intercellular Adhesion Molecules --- Leukocyte Adhesion Molecules --- Saccharide-Mediated Cell Adhesion Molecules --- Adhesion Molecules, Cell --- Adhesion Molecules, Intercellular --- Adhesion Molecules, Leukocyte --- Molecules, Cell Adhesion --- Molecules, Intercellular Adhesion --- Molecules, Leukocyte Adhesion --- Biologic Sciences --- Biological Science --- Science, Biological --- Sciences, Biological --- Biological Sciences --- Life Sciences --- Biologic Science --- Biological Science Discipline --- Discipline, Biological Science --- Disciplines, Biological Science --- Life Science --- Science Discipline, Biological --- Science Disciplines, Biological --- Science, Biologic --- Science, Life --- Sciences, Biologic --- Sciences, Life --- Natural Sciences --- Physical Sciences --- Discipline, Natural Science --- Disciplines, Natural Science --- Natural Science --- Natural Science Discipline --- Physical Science --- Science, Natural --- Science, Physical --- Sciences, Natural --- Sciences, Physical --- Biologic Agents --- Biologic Factors --- Biological Factor --- Factor, Biologic --- Factor, Biological --- Factors, Biological --- Biological Agents --- Agents, Biologic --- Agents, Biological --- Biologic Factor --- Factors, Biologic --- Pharmacologies --- Pharmaceutical Preparations --- Cell Physiological Phenomenon --- Cell Physiological Process --- Physiology, Cell --- Cell Physiology --- Phenomena, Cell Physiological --- Phenomenon, Cell Physiological --- Physiological Process, Cell --- Physiological Processes, Cell --- Process, Cell Physiological --- Processes, Cell Physiological --- Cells --- Therapy --- Treatment --- Therapeutic --- Therapies --- Treatments --- Disease --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Antigen --- Chemistry, Pharmaceutic --- Pharmaceutic Chemistry --- Pharmaceutical Chemistry --- Medicinal Chemistry --- Chemistry, Medicinal --- Glycoprotein --- Neoglycoproteins --- Gene Products, Protein --- Gene Proteins --- Protein Gene Products --- Proteins, Gene --- Drug Prospecting --- Discovery, Drug --- Prospecting, Drug --- Therapy, Drug --- Chemotherapy --- Pharmacotherapy --- Chemotherapies --- Drug Therapies --- Pharmacotherapies --- Therapies, Drug --- Cell Surface Glycoprotein --- Membrane Glycoprotein --- Surface Glycoprotein --- Cell Surface Glycoproteins --- Surface Glycoproteins --- Glycoprotein, Cell Surface --- Glycoprotein, Membrane --- Glycoprotein, Surface --- Glycoproteins, Cell Surface --- Glycoproteins, Membrane --- Glycoproteins, Surface --- Surface Glycoprotein, Cell --- Surface Glycoproteins, Cell --- Cell Surface Antigen --- Immunologic Surface Markers --- Markers, Immunological Surface --- Surface Antigen --- Surface Markers, Immunologic --- Cell Surface Antigens --- Surface Antigens --- Surface Markers, Immunological --- Antigen, Cell Surface --- Antigen, Surface --- Antigens, Cell Surface --- Immunological Surface Markers --- Markers, Immunologic Surface --- Surface Antigen, Cell --- Surface Antigens, Cell --- pharmacology --- physiology --- therapy --- drug therapy --- therapeutic use --- Molecular biology. --- Proteins. --- Biophysics. --- Biological physics. --- Biological and Medical Physics, Biophysics. --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Membranes (Biology) --- Glycocalyces --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Biomolecules. --- Proteins . --- Cell membranes . --- Biological physics --- Biology --- Physics --- Molecular biochemistry --- Molecular biophysics --- Biophysics --- Biomolecules --- Systems biology --- Proteids --- Polypeptides --- Proteomics