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The peer review process can lead to changes in the interpretation of the slides and the reported results, and potentially the outcome and conclusions of the study. The purpose of this document is to provide guidance to pathologists, test facility management, study directors and quality assurance personnel on how the peer review of histopathology should be planned, managed, documented and reported in order to meet GLP expectations and requirements. This document is a complement to the guidance provided in section 3.6.3.7 of OECD Guidance Document 116 (series on testing and assessment), whose focus is on how histopathology peer review should be conducted.
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Vers un nouveau « business model » de la biologie médicale La réforme de la biologie et son corollaire – l’accréditation – a provoqué une concentration du secteur de la biologie médicale, marquée par une forte réduction du nombre des entités juridiques et une augmentation de leur taille moyenne. Les regroupements sont en effet apparus aux acteurs de la biologie médicale comme inévitables pour faire face aux enjeux futurs du secteur, à savoir : conformité médicale et efficience de la gestion dans un cadre tarifaire contraint. Dans cet ouvrage, biologistes, syndicats, avocats, financiers, experts-comptables et banquiers livrent leurs expertises. Ils partagent les clés de leurs réussites mais aussi les échecs auxquels ils ont été confrontés. Dans ces nouvelles structures nées de processus de fusions/acquisitions complexes, mettant en oeuvre l’ingénierie juridique, financière, fiscale d’autres secteurs d’activité, les biologistes comprennent qu’ils quittent leur ancien mode d’exercice libéral. La mise en place d’une gouvernance dynamique avec son organigramme définissant responsabilités et obligations devient essentielle pour assurer le management des laboratoires multisites. Ainsi, organiser la gouvernance du laboratoire revient à s’accorder sur les fonctions de(s) dirigeant(s), se répartir l’exercice des pouvoirs de gestion et de management, favoriser la circulation de l’information au sein de la structure et rechercher l’adhésion des biologistes et du personnel, en vue de la création de valeur de l’entité : un défi, une révolution auxquels ne prépare pas la formation universitaire médicale. Dans ce livre qui se veut tout à la fois témoignage et vade-mecum à l’usage des biologistes, les auteurs évoquent aussi les perspectives d’évolution de la biologie médicale française. Les contours du nouveau « business model » du secteur ne sont en effet, à ce jour, pas encore totalement tracés. La première étape touchait, le regroupement des structures juridiques. Il était ainsi essentiellement quantitatif. La seconde étape sera cette fois plus qualitative ; comment concilier le respect des normes de l’accréditation, les baisses successives de nomenclatures, la maîtrise des coûts de production et de services proposées par les techniques du Lean Management et l’évolution de la discipline médicale notamment permise par le Big Data et enjeux de recherche des biotech et laboratoires mondiaux ? Mais si l’efficience est désormais indispensable au sein du laboratoire de biologie médicale, chacun doit cependant garder en tête que le coeur du métier de biologiste n’est pas « la course aux tubes », mais bien la réponse à une demande de diagnostic en vue de rendre le meilleur service médical aux patients.
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Environmental laboratories --- Laboratories --- Quality control. --- Laboratory facilities --- Research buildings --- Science laboratories --- Scientific laboratories --- Science rooms and equipment
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Maintaining consistent and reliably high success rates is a daily challenge for every IVF laboratory. This step-by-step guide is an essential aid in navigating the complex maze of physical, chemical, biological, and logistic parameters that underpin successful gamete and embryo culture: temperature, pH, osmolality, gas supplies, air quality, light exposure, infections, managing supplies, personnel, as well as overall quality control. Numerous real-life troubleshooting case reports are presented, identifying all aspects necessary for troubleshooting. Process maps and flow charts accompanying each chapter offer a logical and systematic approach to problem solving in the laboratory. This is an essential resource for scientists in assisted reproductive technology and specialists in reproductive biology and medicine, helping IVF clinics to achieve the dream of every infertile couple: the birth of a healthy child.
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In 1959, the electronics manufacturer Stromberg-Carlson produced the S-C 4020, a device that allowed mainframe computers to present and preserve images. In the mainframe era, the output of text and image was quite literally peripheral; the S-C 4020 -- a strange and elaborate apparatus, with a cathode ray screen, a tape deck, a buffer unit, a film camera, and a photo-paper camera -- produced most of the computer graphics of the late 1950s and early 1960s. At Bell Laboratories in Murray Hill, New Jersey, the S-C 4020 became a crucial part of ongoing encounters among art, science, and technology. In this book, Zabet Patterson examines the extraordinary uses to which the Bell Labs SC-2040 was put between 1961 and 1972, exploring a series of early computer art projects shaped by the special computational affordances of the S-C 4020. The S-C 4020 produced tabular data, graph plotting and design drawings, grid projections, and drawings of axes and vectors; it made previously impossible visualizations possible. Among the works Patterson describes are E. E. Zajac's short film of an orbiting satellite, which drew on the machine's graphic capacities as well as the mainframe's calculations; a groundbreaking exhibit of "computer generated pictures" by Bľa Julesz and Michael Noll, two scientists interested in visualization; animations by Kenneth Knowlton and the Bell Labs artist-in-residence Stan VanDerBeek; and Lillian Schwartz's "cybernetic" film Pixillation.Arguing for the centrality of a peripheral, Patterson makes a case for considering computational systems not simply as machines but in their cultural and historical context.
Computer art. --- Computer peripherals. --- AT & T Bell Laboratories.
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Environmental planning --- Archeology --- archaeology --- laboratories --- Brussel, Abdij van Ter Kameren --- Vesalius, Andreas --- Lacoste, Henry --- Brussels --- laboratories [buildings]
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"Reference manual for planning, design, and operation of laboratory HVAC systems to reduce the laboratory's energy footprint while ensuring safety, providing good comfort and indoor air quality, and protecting the integrity of experiments; includes online access to electronic design tools that illustrate features of laboratories and provide practical design aids"--
Laboratories --- Buildings --- Civil Engineering --- Civil & Environmental Engineering --- Engineering & Applied Sciences --- Environmental engineering (Buildings) --- Environmental engineering --- Architecture --- Sanitary engineering --- Laboratory facilities --- Research buildings --- Science laboratories --- Scientific laboratories --- Science rooms and equipment --- Design and construction --- Safety measures --- Energy conservation --- Human factors --- Construction
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Laboratories --- Technology transfer --- Public-private sector cooperation --- Law and legislation --- United States. --- Management.
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Biosecurity --- Biological laboratories --- Life sciences --- Rules and practice. --- Safety measures --- Management --- Safety measures. --- Research
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