Listing 1 - 2 of 2 |
Sort by
|
Choose an application
Cet essai mesure les aberrations chromosomiques structurales (de type chromosomique et chromatidique) qui surviennent dans les spermatogonies et devrait par conséquent permettre de prévoir l'induction de mutations héritées dans les cellules germinales. L’essai d’aberration chromosomique pratiqué in vivo sur des spermatogonies de mammifères est destiné à détecter les produits chimiques qui causent des aberrations chromosomiques structurales dans les cellules de spermatogonies de mammifère (1) (2) (3). Par ailleurs, cet essai se prête bien à l’évaluation de la génotoxicité, car, malgré des variations entre les espèces, les facteurs du métabolisme in vivo, la pharmacocinétique et les processus de réparation de l’ADN sont actifs et contribuent aux réponses. La Ligne directrice 483 originale a été adoptée en 1997. La présente version modifiée de la ligne directrice reflète les connaissances scientifiques acquises après de nombreuses années d’expérience de cet essai et tient compte des possibilités de l’intégrer ou de le combiner à d’autres études de toxicité ou de génotoxicité.
Chromosome abnormalities. --- Chemical tests and reagents. --- Toxicity testing. --- Poisons --- Toxicological testing --- Toxicology --- Toxicology testing --- Toxicology, Experimental --- Chemical reagents --- Reagents, Chemical --- Indicators and test-papers --- Chromosomal aberrations --- Chromosome anomalies --- Chromosomes --- Karyotypes --- Mutation (Biology) --- Testing
Choose an application
This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.
Gene Expression Regulation, Neoplastic --- Chromosomal Instability --- Translocation, Genetic --- Aneuploidy --- Neoplasms --- Diseases --- Ploidies --- Genomic Instability --- Gene Expression Regulation --- Chromosome Aberrations --- Mutagenesis --- Pathologic Processes --- Mutation --- Genetic Phenomena --- Genetic Processes --- Pathological Conditions, Signs and Symptoms --- Phenomena and Processes --- Genetic Variation --- Oncology --- Medicine --- Health & Biological Sciences --- Cancer cells. --- Chromosome abnormalities. --- Chromosomal aberrations --- Chromosome anomalies --- Medicine. --- Cancer research. --- Human genetics. --- Oncology. --- Medicine & Public Health. --- Cancer Research. --- Human Genetics. --- Tumors --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Cancer research --- Clinical sciences --- Medical profession --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Chromosomes --- Karyotypes --- Mutation (Biology) --- Cells --- Pathology, Cellular --- Oncology .
Listing 1 - 2 of 2 |
Sort by
|