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This book surveys healthy and diseased vascular systems in a multitude of model organisms and systems. It explores a plethora of functions, characteristics, and pathologies of the vascular system such as angiogenesis, fibroblast growth factor signaling, lymphangiogenesis, junctional signaling, the extracellular matrix, vascular permeability, leukocyte extravasation, axon guidance factors, the angiopoietin system, and chronic obstructive lung disease. Following a preface from leading researcher Dr. Holger Gerhardt, the text is divided into three sections- the first examining the development of the vascular system in a variety of contexts, the second delving into its homeostatic characteristics, and the third discussing its pathophysiologies.  The sixteen chapters, which represent international clinical and research perspectives, highlight the importance of molecular and signaling pathways for translational basic science and clinical medicine. Additionally, the text explores new and exciting fields in vascular biology research.   Comprehensive in both content and approach, Vascular Signaling in Health and Disease is ideal for graduate students, researchers, and clinicians interested in vascular biology, pneumology, and molecular biology.

Cellular signal transduction --- Endothelial cells --- Endothelial Cells --- Signal Transduction --- Biochemical Processes --- Epithelial Cells --- Cells --- Biochemical Phenomena --- Anatomy --- Chemical Phenomena --- Phenomena and Processes --- Physiology --- Human Anatomy & Physiology --- Health & Biological Sciences --- Cellular signal transduction. --- Endothelial cells. --- Endotheliocytes --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Medicine. --- Human physiology. --- Angiology. --- Hematology. --- Systems biology. --- Cell physiology. --- Biomedicine. --- Human Physiology. --- Cell Physiology. --- Systems Biology. --- Epithelial cells --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Angiography. --- Biological models. --- Models, Biological --- Blood-vessels --- Diagnosis, Radioscopic --- Radiography, Medical --- Haematology --- Internal medicine --- Blood --- Cell function --- Cytology --- Human biology --- Medical sciences --- Human body --- Radiography --- Diseases --- Computational biology --- Bioinformatics --- Biological systems --- Molecular biology

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Plants are endowed with innate immune system, which acts as a surveillance system against possible attack by pathogens. Plant innate immune systems have high potential to fight against viral, bacterial, oomycete, and fungal pathogens and protect the crop plants against wide range of diseases. However, the innate immune system is a sleeping system in unstressed healthy plants. Fast and strong activation of the plant immune responses aids the host plants to win the war against the pathogens. Plant hormone signaling systems including salicylate (SA), jasmonate (JA), ethylene (ET), abscisic acid (ABA), auxins, cytokinins, gibberellins, and brassinosteroids signaling systems play a key role in activation of the sleeping immune systems.  Suppression or induction of specific hormone signaling systems may result in disease development or disease resistance. Specific signaling pathway has to be activated to confer resistance against specific pathogen in a particular host. Two forms of induced resistance, systemic acquired resistance (SAR) and induced systemic resistance (ISR), have been recognized based on the induction of specific hormone signaling systems. Specific hormone signaling system determines the outcome of plant-pathogen interactions, culminating in disease development or disease resistance. Susceptibility or resistance against a particular pathogen is determined by the action of the signaling network. The disease outcome is often determined by complex network of interactions among multiple hormone signaling pathways. Manipulation of the complex hormone signaling systems and fine tuning the hormone signaling events would help in management of various crop diseases. The book highlights the cutting-edge breakthroughs in the field of plant hormones-modulated priming plant innate immunity. It describes histone memory for information storage in gene priming, chromatin remodeling in priming, histone modifications in gene priming, DNA methylation in trans generational SAR, mobile signal complex, membrane signal receptor complex, Mediator complex, GCC motifs in JA responsive promoters, JAZ proteins, JAZ-COI1 complex, assembly of NINJA-IPL corepressor complex in JAZ scaffold, histone acetylation in JA-mediated signaling, crosstalk between hormones- and small RNA signaling systems, PYR/PYL/RCAR-PP2C-SnRK2 signaling complex, stomatal closure immune responses, hijacking hormone signaling pathways for pathogenesis, ubiquitin-proteasomes in hormone signaling pathways, phosphorelay signaling systems, DELLA proteins, and PAMP-PRR-hormone signaling interplay. The author explains the complex hormone signaling network providing more than 100 figures elucidating the different plant hormone biosynthesis pathways and also their signal transduction pathways. These features and more make this book the most up to date resource in the most fascinating field of ‘Signals and Signaling Systems in Plant Innate Immunity’. .

Life Sciences. --- Plant Pathology. --- Plant Physiology. --- Microbiology. --- Biotechnology. --- Agriculture. --- Life sciences. --- Plant diseases. --- Plant physiology. --- Sciences de la vie --- Biotechnologie --- Agriculture --- Microbiologie --- Plantes --- Physiologie végétale --- Maladies et fléaux --- Plant cellular signal transduction. --- Plant immunology. --- Earth & Environmental Sciences --- Plant Sciences --- Plant hormones. --- Hormones (Plants) --- Phytohormones --- Plant pathology. --- Hormones --- Phytochemicals --- Plant regulators --- Cellular signal transduction --- Plant cellular control mechanisms --- Farming --- Husbandry --- Industrial arts --- Life sciences --- Food supply --- Land use, Rural --- Chemical engineering --- Genetic engineering --- Microbial biology --- Biology --- Microorganisms --- Botany --- Plants --- Physiology --- Communicable diseases in plants --- Crop diseases --- Crops --- Diseases of plants --- Microbial diseases in plants --- Pathological botany --- Pathology, Vegetable --- Phytopathology --- Plant pathology --- Vegetable pathology --- Agricultural pests --- Crop losses --- Diseased plants --- Phytopathogenic microorganisms --- Plant pathologists --- Plant quarantine --- Pathology --- Diseases and pests --- Diseases --- Wounds and injuries

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This book provides a simplified, yet comprehensive, overview of the signalling pathways operating between and inside cells, which will help younger oncologists find their way in the labyrinth of signalling pathways and in the multitude of signals and signal receptors, transducers and effectors that contribute to oncogenesis. This comprehensive reference text is based on the master’s courses delivered by Prof. Jacques Robert to graduate students at the University of Bordeaux, France. It includes a large number of colour schemas and figures that have been improved year after year for educational purposes. Signalling pathways are described individually and in depth, but without ignoring the multiplicity of interconnections and crosstalk. The presentation of each pathway is followed by a brief description of the alterations found in cancers as well as of the targeted pharmacological approaches that can be used to prevent or overcome the consequences of these oncogenic alterations. The basic mechanisms of molecular biology at the DNA replication, RNA transcription and protein activity levels are presented in a series of didactic annexes, enabling readers to better understand the alterations in signalling pathways.

Biomedicine. --- Cancer Research. --- Oncology. --- Molecular Medicine. --- Pharmacology/Toxicology. --- Cell Biology. --- Medicine. --- Toxicology. --- Cytology. --- Médecine --- Cancérologie --- Toxicologie --- Cytologie --- Medicine --- Health & Biological Sciences --- Oncology --- Cancer cells. --- Cellular signal transduction. --- Cell interaction. --- Cell-cell interaction --- Cell communication --- Cellular communication (Biology) --- Cellular interaction --- Intercellular communication --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Cancer research. --- Molecular biology. --- Pharmacology. --- Cell biology. --- Cellular control mechanisms --- Bioenergetics --- Information theory in biology --- Cells --- Pathology, Cellular --- Oncology  . --- Cell biology --- Cellular biology --- Biology --- Cytologists --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Tumors --- Toxicology --- Health Workforce --- Biomedicine, general. --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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The book considers signaling events from the zygote embryo through to the blastocyst with relevant data from embryonic stem (ES) cells, including dialogue with the extracellular environment and with the maternal tract during the implantation process. Application of the knowledge described to improve the success of human and animal assisted conception is considered where appropriate, but the focus is largely on fundamental rather than applied cell/molecular biology, as this is the area that has historically been neglected. While the general features of metabolism during preimplantation development are well established, especially in terms of nutrient requirements, uptake and fate, remarkably little is known about early embryo signaling events, intracellular or intercellular, between individual embryos in vitro or with the female reproductive tract in vivo. This contrasts with the wealth of information on cell signaling in somatic cells and tissues, as a glance at any textbook of biochemistry illustrates. This lack of information is such that our understanding of the molecular cell biology of early embryos -- a prerequisite to defining the mechanisms which regulate development at this critical stage of the life cycle -- is seriously incomplete. This volume is the first to address this issue by describing the current state of knowledge on cell signaling during mammalian early embryo development and highlighting priority areas for research.

Life Sciences. --- Embryology. --- Cell Biology. --- Reproductive Medicine. --- Life sciences. --- Cytology. --- Sciences de la vie --- Cytologie --- Embryologie --- Cells. --- Embryos. --- Mammals -- Reproduction. --- Embryology --- Mammals --- Embryonic stem cells --- Cellular signal transduction --- Cell interaction --- Embryonic and Fetal Development --- Cell Physiological Processes --- Biochemical Processes --- Embryonic Structures --- Stem Cells --- Second Messenger Systems --- Cell Physiological Phenomena --- Cells --- Anatomy --- Biochemical Phenomena --- Morphogenesis --- Reproduction --- Growth and Development --- Chemical Phenomena --- Phenomena and Processes --- Physiological Processes --- Reproductive Physiological Processes --- Reproductive Physiological Phenomena --- Physiological Phenomena --- Reproductive and Urinary Physiological Phenomena --- Cell Communication --- Embryonic Stem Cells --- Embryonic Induction --- Embryo Implantation --- Embryonic Development --- Calcium Signaling --- Signal Transduction --- Embryo, Mammalian --- Biology --- Health & Biological Sciences --- Biophysics --- Embryos --- Reproduction. --- Animal embryos --- Animals --- Reproductive medicine. --- Cell biology. --- Animal embryology --- Development, Embryological --- Development, Embryonic --- Development, Zygotic --- Embryogenesis --- Embryogeny --- Embryological development --- Embryonic development --- Zoology --- Zygote development --- Zygotes --- Zygotic development --- Zygotic embryogenesis --- Developmental biology --- Morphology (Animals) --- Cell biology --- Cellular biology --- Cytologists --- Human reproduction --- Human reproductive health --- Human reproductive medicine --- Reproductive medicine --- Health --- Biosciences --- Sciences, Life --- Science --- Development --- Health aspects --- Organisms --- Cytology