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Cell death --- Cellules --- Laboratory manuals --- Mort --- Manuels de laboratoire --- Cell Death --- Death, Cell --- Cell Aging --- Cell degeneration --- Cells --- Death (Biology) --- Cellular Senescence --- Cell Death.

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This comprehensive volume presents data describing the role of oxidative stress in anterior eye disease. The content is divided into three logical parts: basic science of the cornea, basic science of the lens, and clinical practices. The first two parts include eighteen chapters that discuss topics ranging from oxidative stress and dry eye disease, endogenous protection of corneal cells against oxidative damage, the therapeutic potential of corneal stem cells, etiology of cataracts and preventive measures, corneal degeneration through oxidative stress and cataract formation, and function and dysregulation of ion channels and transporters in the ocular lens, among others. The concluding part is comprised of four chapters devoted to advancements in corneal surgery, cataract and diabetic retinopathy, the clinical treatment of cataracts including traumatic cataracts, and cataracts in the pediatric age group. Studies on the Cornea and Lens is an essential addition to the library or department of physicians and scientists who treat or research these ocular conditions, particularly cataracts. It is also a key resource for cell biologists studying oxidative stress. This book is an authoritative contribution to Springer’s Oxidative Stress in Applied Basic Research and Clinical Practice series.

Life Sciences. --- Oxidative Stress. --- Ophthalmology. --- Apoptosis. --- Life sciences. --- Cytology. --- Sciences de la vie --- Ophtalmologie --- Cytologie --- Cornea -- Diseases. --- Cornea. --- Crystalline lens. --- Eye -- Diseases. --- Eye Diseases --- Metabolism --- Metabolic Phenomena --- Diseases --- Phenomena and Processes --- Oxidative Stress --- Lens Diseases --- Biology --- Health & Biological Sciences --- Cytology --- Lens, Crystalline --- Oxidative stress. --- Anterior segment (Eye) --- Eye --- Medicine --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Cell death --- Oxidation-reduction reaction --- Stress (Physiology)

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The field of protein kinases has greatly impacted our understanding of the basic mechanisms in cell function. The field has also been a major focus of drug development that considers the broad reach of the protein kinase function under diverse conditions. One member of the kinome, protein kinase CK2, continues to emerge as a major signaling molecule involved in diverse functions in health and disease. This kinase has unique features, most notably its ubiquitous and highly conserved nature. Its vast number of potential substrates exemplifies its involvement in various functions in cells under both the normal and diseased states. Of particular note is the observation that due to its ubiquitous nature, CK2 has been found to be dysregulated in all cancers that have been examined. As such, it is now being considered a potentially important target for cancer therapy. Protein Kinase CK2 plays equally important functions in development and intracellular activities, and has a global impact on cell growth and proliferation. An additional key function of CK2 is the impact of its activity on cell death processes. Given the vast nature of its functions, CK2 has been proposed to serve as a “master regulator” of cell function. The chapters included in this work cover a wide range of topics dealing with some of the functions mentioned above, providing an important starting point for research investigators and graduate students interested in this field.

Biomedicine. --- Cancer Research. --- Protein Science. --- Apoptosis. --- Medicine. --- Oncology. --- Biochemistry. --- Cytology. --- Médecine --- Cancérologie --- Biochimie --- Cytologie --- Cancer -- Chemotherapy. --- Mouse leukemia complex -- Chemotherapy. --- Protein kinase CK2. --- Medicine --- Health & Biological Sciences --- Oncology --- Casein kinase 2 --- Casein kinase II --- Protein kinase CKII --- Cancer research. --- Proteins. --- Protein kinases --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Tumors --- Composition --- Proteins . --- Cell death --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Cancer research

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This interdisciplinary thesis introduces a systems biology approach to study the cell fate decision mediated by autophagy. A mathematical model of interaction between Autophagy and Apoptosis in mammalian cells is proposed. In this dynamic model autophagy acts as a gradual response to stress (Rheostat) that delays the initiation of bistable switch of apoptosis to give the cells an opportunity to survive. The author shows that his dynamical model is consistent with existing quantitative measurements of time courses of autophagic responses to cisplatin treatment. To understand the function of this response in cancer cells, he has provided a systems biology experimental framework to study quantitative and dynamical aspects of autophagy in single cancer cells using live-cell imaging and quantitative fluorescence microscopy. This framework can provide new insights on function of autophagic response in cancer cells.

Materials Science. --- Biomaterials. --- Computational Biology/Bioinformatics. --- Cancer Research. --- Cell Biology. --- Biophysics and Biological Physics. --- Oncology. --- Bioinformatics. --- Cytology. --- Cancérologie --- Bio-informatique --- Cytologie --- Health & Biological Sciences --- Biomedical Engineering --- Apoptosis --- Cell determination --- Mathematical models. --- Cell commitment --- Cell fate determination --- Commitment (Cytology) --- Determination (Cytology) --- Materials science. --- Cancer research. --- Cell biology. --- Biophysics. --- Biological physics. --- Developmental cytology --- Transdetermination (Cytology) --- Cell death --- Biological and Medical Physics, Biophysics. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Tumors --- Bio-informatics --- Biological informatics --- Information science --- Computational biology --- Systems biology --- Biocompatible materials --- Biomaterials --- Medical materials --- Medicine --- Biomedical engineering --- Materials --- Biocompatibility --- Prosthesis --- Data processing --- Biological physics --- Medical sciences --- Physics --- Cancer research --- Bioartificial materials --- Hemocompatible materials --- Biomaterials (Biomedical materials)

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Inflammation is the very natural process of our body; it does its work immediately and smoothly along with lots of helpers. Inflammation is linked to immune system as acute inflammatory or pro-inflammatory phase through macrophage activation. This book is for researchers and scholars in the field of life sciences and medical sciences. The book contains all inflammatory sources around the world. It emphasizes on anti-inflammatory sources along with its active inflammatory constituents and other medicinal uses with authentic references. Anti-inflammation is a kind of activity with is found in nearly all of the natural sources used for major biological activities. So, the book helps them to correlate their activity of interest with anti-inflammatory source.  The present work deals with illustrative representation of inflammation, causes of inflammation, inflammatory mediators, anti-inflammatory sources other uses and inflammation and lifestyle. It mainly provides the researchers the updated information from the ancient to the most recent ongoing research on inflammation. This book imparts pace to their idea of thinking, assist to make clear predictions before proceeding to research. The introduction includes natural sources of inflammation and its benefits; the sources are from plant, animal and marine. The book tells how these sources are useful for us to cure several diseases and opens new path for further research. Inflammation part of the book is well presented along with its phases, types and other diseases interrelated with inflammation. Inflammatory mediators, the foremost player of inflammation are defined in a very pleasant and convenient manner. The chapter includes both cell- derived and plasma - derived mediators illustratively with their synthesis and action. Natural source of anti-inflammation is the heart chapter of this book which contains all anti-inflammation sources from plants, marine and animals. This chapter also contains short description of most of the sources, its availability and uses. The authors have also added inflammatory models for assessment of biological activities of natural sources both in vitro and in vivo. Inflammation free lifestyle is described very nicely in the book. The contents are very specific and relevant to its topic; all the data provided is unique and useful. The anti-inflammatory table includes sources, plant parts used, active constituents and other uses. This data provides ample information regarding anti-inflammatory research and innovation. The highlights of this book shall be:   -Describes almost all anti-inflammatory sources around the globe at one place in a more convenient tabulated form -Illustrative representation makes the book more attractive and interactive.

Biomedicine. --- Immunology. --- Biomedicine general. --- Pharmacology/Toxicology. --- Cytokines and Growth Factors. --- Apoptosis. --- Medicine. --- Toxicology. --- Cytokines. --- Cytology. --- Médecine --- Immunologie --- Toxicologie --- Cytokines --- Cytologie --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Inflammation. --- Inflammatory process --- Pharmacology. --- Growth factors. --- Pathology --- Anti-inflammatory agents --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Cellular immunity --- Immune response --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Immunobiology --- Serology --- Regulation --- Toxicology --- Biomedicine, general. --- Health Workforce --- Cell death --- Cell growth factors --- Cellular growth factors --- Growth peptides --- Growth promoting substances --- Growth substances --- Peptide growth factors --- Peptide regulatory factors --- Polypeptide growth factors --- Peptides --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect