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In the last decade, the synergistic interaction of neurosurgeons, engineers, and neuroscientists, combined with new technologies, has enabled scientists to study the awake, behaving human brain directly. These developments allow cognitive processes to be characterised at unprecedented resolution: single neuron activity. In this volume, experts document the successes, challenges, and opportunity in an emerging field.
Neurons -- Physiology. --- Neurons --- Brain mapping --- Neural transmission --- Cognition --- Central Nervous System --- Electrophysiological Processes --- Biological Science Disciplines --- Nervous System --- Diagnostic Imaging --- Investigative Techniques --- Mental Processes --- Signal Transduction --- Nervous System Physiological Processes --- Diagnostic Techniques, Neurological --- Cells --- Biochemical Processes --- Physiological Processes --- Anatomy --- Electrophysiological Phenomena --- Diagnostic Techniques and Procedures --- Natural Science Disciplines --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Nervous System Physiological Phenomena --- Cell Physiological Processes --- Psychological Phenomena and Processes --- Disciplines and Occupations --- Physiological Phenomena --- Chemical Processes --- Musculoskeletal and Neural Physiological Phenomena --- Diagnosis --- Biochemical Phenomena --- Psychiatry and Psychology --- Cell Physiological Phenomena --- Chemical Phenomena --- Phenomena and Processes --- Synaptic Transmission --- Physiology --- Brain --- Brain Mapping --- Human Anatomy & Physiology --- Health & Biological Sciences --- Neuroscience --- Physiology. --- Cell physiology --- Neurophysiology
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Regulated Cell Death Part A & Part B of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches.Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in biomineralization science
Apoptosis. --- Cancer cells -- Variation. --- Cell death. --- Neoplasms -- Etiology. --- Cell Physiological Processes --- Cell Physiological Phenomena --- Phenomena and Processes --- Cell Death --- Biology --- Health & Biological Sciences --- Cytology --- Cell degeneration --- Cells --- Death (Biology)
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Virology --- Virus Diseases --- Virus Physiological Phenomena --- Virology. --- Physiology, Viral --- Viral Physiological Concepts --- Viral Physiological Phenomena --- Viral Physiological Process --- Virus Physiological Concepts --- Virus Physiological Phenomenon --- Virus Physiological Process --- Virus Physiology --- Viral Physiological Processes --- Viral Physiology --- Virus Physiological Processes --- Concept, Viral Physiological --- Concept, Virus Physiological --- Concepts, Viral Physiological --- Concepts, Virus Physiological --- Phenomena, Viral Physiological --- Phenomena, Virus Physiological --- Phenomenon, Virus Physiological --- Phenomenons, Virus Physiological --- Physiological Process, Viral --- Physiological Process, Virus --- Physiological Processes, Viral --- Physiological Processes, Virus --- Physiology, Virus --- Process, Viral Physiological --- Process, Virus Physiological --- Processes, Viral Physiological --- Processes, Virus Physiological --- Viral Physiological Concept --- Virus Physiological Concept --- Viruses --- Viral Diseases --- Viral Infections --- Virus Infections --- Disease, Viral --- Disease, Virus --- Diseases, Viral --- Diseases, Virus --- Infection, Viral --- Infection, Virus --- Infections, Viral --- Infections, Virus --- Viral Disease --- Viral Infection --- Virus Disease --- Virus Infection --- physiology --- HIV and AIDS --- virology --- virological methods --- molecular microbiology --- Microbiology --- Microbiology & Immunology --- Virus Diseases. --- Virus Physiological Phenomena.
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Reproduction --- Reproductive Physiological Processes. --- Genital Diseases, Female. --- Genital Diseases, Male. --- Pregnancy Complications. --- Sexually Transmitted Diseases. --- MEDICAL / Physiology --- SCIENCE / Life Sciences / Human Anatomy & Physiology --- Human reproduction. --- Reproductive health. --- Generative organs --- Reproduction humaine --- Santé de la reproduction --- Organes génitaux --- physiology. --- Diseases. --- Maladies --- Reproductive Physiological Processes --- Genital Diseases, Female --- Genital Diseases, Male --- Pregnancy Complications --- Sexually Transmitted Diseases --- physiology --- Reproductive Physiological Phenomena --- Reproductive Physiological Phenomena. --- Santé de la reproduction --- Organes génitaux --- Reproduction - physiology
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This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods providing a a theoretical overview on metabolic alterations of cancer cells and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo. Malignant cells exhibit metabolic changes when compared to their normal counterparts, owing to both genetic and epigenetic alterations. Although such a metabolic rewiring has recently been indicated as ""yet another"" general hallmark of canc
Biochemistry -- Analysis. --- Biochemistry -- Technique. --- Biotechnology -- Methodology. --- Cells -- Laboratory manuals. --- Enzymes -- Analysis. --- Enzymes. --- Diseases --- Metabolism --- Cell Physiological Processes --- Drug Therapy --- Growth --- Metabolic Phenomena --- Therapeutics --- Cell Physiological Phenomena --- Growth and Development --- Phenomena and Processes --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Physiological Processes --- Physiological Phenomena --- Molecular Targeted Therapy --- Cell Growth Processes --- Neoplasms --- Metabolic Networks and Pathways --- Cancer --- Cell metabolism --- Cancer cells --- Cytopathology --- Research --- Methodology. --- Biochemistry. --- Cancer. --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Biocatalysts --- Ferments --- Soluble ferments --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Composition --- Tumors --- Catalysts --- Proteins --- Enzymology --- Biology --- Chemistry --- Medical sciences
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Offering detailed and integrated information on how drugs, biologics, stress, and manipulations impact pregnancy in the mouse model, this reference highlights techniques used to analyze mouse pregnancy. Covers monitoring of the cardiovascular system, gestational programming of chronic adult disease, epigenetic regulation, gene imprinting, and stem cells.
Placenta. --- Pregnancy. --- Murinae --- Reproduction --- Reproductive Physiological Processes --- Muridae --- Reproductive Physiological Phenomena --- Rodentia --- Mammals --- Reproductive and Urinary Physiological Phenomena --- Phenomena and Processes --- Vertebrates --- Chordata --- Animals --- Eukaryota --- Organisms --- Mice --- Pregnancy --- Zoology --- Health & Biological Sciences --- Reproduction. --- House mice --- House mouse --- Mouse --- Mus musculus --- Rodents
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Anatomy --- Physiological Phenomena. --- Anatomies --- Physiological Concepts --- Physiological Phenomenon --- Physiological Process --- Physiological Processes --- Concept, Physiological --- Concepts, Physiological --- Phenomena, Physiological --- Phenomenas, Physiological --- Phenomenon, Physiological --- Physiological Concept --- Process, Physiological --- Processes, Physiological --- Human anatomy --- Physiology. --- Anatomy. --- Animal anatomy --- Animals --- Biology --- Physiology --- Animal physiology --- Physiological Phenomena
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Musculoskeletal and Neural Physiological Phenomena --- Biological Science Disciplines --- Physical Examination --- Movement --- Sports --- Motor Activity --- Locomotion --- Diagnostic Techniques and Procedures --- Musculoskeletal Physiological Processes --- Phenomena and Processes --- Recreation --- Natural Science Disciplines --- Diagnosis --- Disciplines and Occupations --- Leisure Activities --- Human Activities --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Anthropology, Education, Sociology and Social Phenomena --- Walking --- Gait --- Physiology --- Musculoskeletal Physiological Phenomena
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This volume represents an up-to-date overview on the major areas of gynecological endocrinology, providing the reader with a complete explanation of female endocrine regulation and metabolism and relevant disorders and treatment. It is published within the International Society of Gynecological Endocrinology (ISGE) Series and is based on the 2013 International School of Gynecological and Reproductive Endocrinology Summer Course. The book covers a very wide range of topics – from primary amenorrhea to menopause, from the impact of ovarian surgery on fertility to fertility cryopreservation, from metabolic syndrome and polycystic ovary to premature ovarian failure and from the clinical impact of selective progesterone receptor modulators to the use of progesterone in prevention of premature labor. It will be an important tool for obstetricians and gynecologists, endocrinologists and experts in women’s health as well as interested GPs.
Endocrine gynecology. --- Gynecology. --- Medicine. --- Growth and Development --- Climacteric --- Ovarian Diseases --- Pathologic Processes --- Age Groups --- Gonadal Disorders --- Reproductive Physiological Phenomena --- Physiological Processes --- Pathological Conditions, Signs and Symptoms --- Sexual Development --- Adnexal Diseases --- Persons --- Diseases --- Reproductive and Urinary Physiological Phenomena --- Named Groups --- Endocrine System Diseases --- Reproductive Physiological Processes --- Genital Diseases, Female --- Physiological Phenomena --- Phenomena and Processes --- Female Urogenital Diseases --- Female Urogenital Diseases and Pregnancy Complications --- Primary Ovarian Insufficiency --- Adolescent --- Aging --- Menopause --- Menstruation Disturbances --- Medicine --- Health & Biological Sciences --- Gynecology & Obstetrics --- Women --- Generative organs, Female --- Infertility --- Endocrine system --- Diseases. --- Treatment. --- Involuntary childlessness --- Sterility --- Sterility in humans --- Human females --- Wimmin --- Woman --- Womon --- Womyn --- Gynecologic endocrinology --- Endocrinology. --- Reproductive medicine. --- Medicine & Public Health. --- Reproductive Medicine. --- Human reproduction --- Human reproductive health --- Human reproductive medicine --- Reproductive medicine --- Health --- Internal medicine --- Hormones --- Gynaecology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health aspects --- Childlessness --- Generative organs --- Fertility, Human --- Sterilization (Birth control) --- Gynecology --- Females --- Human beings --- Femininity --- Endocrine glands --- Endocrinology --- Endocrine aspects --- Gynecology . --- Endocrinology .
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This book synthesizes the major research advances in molecular, biochemical, and translational aspects of aging and heart failure over the last four decades and addresses future directions in management and drug discovery. It presents clinical issues and molecular mechanisms related to heart failure, including the changing demographics in the aging population with heart failure; hypertension and prevention of diastolic heart failure in the aging population; polypharmacy and adverse drug reactions in the aging population with heart failure; changes in the heart that accompany advancing age from humans to molecules; aging-associated alterations in myocardial inflammation and fibrosis; and aging-related changes in mitochondrial function and implications for heart failure therapy. The book succinctly summarizes the large volume of data on these key topics and highlights novel pathways that need to be explored. Featuring contributions from leading clinician-scientists, Aging and Heart Failure: Mechanisms and Management is an authoritative resource on the major clinical issues in heart failure therapy in the elderly for cardiologists, gerontologists, and internists.
Angina pectoris. --- Cardiology. --- Geriatrics. --- Heart failure. --- Internal medicine. --- Medicine. --- Older people -- Medical care. --- Growth and Development --- Heart Diseases --- Adult --- Cardiovascular Diseases --- Age Groups --- Physiological Processes --- Physiological Phenomena --- Persons --- Diseases --- Phenomena and Processes --- Named Groups --- Aged --- Heart Failure --- Aging --- Medicine --- Health & Biological Sciences --- Older people --- Medical care. --- Cardiac failure --- Cardiac insufficiency --- Failure, Heart --- Insufficiency, Cardiac --- Medicine & Public Health. --- Geriatrics/Gerontology. --- Internal Medicine. --- Heart --- Cardiac arrest --- Gerontology --- Internal medicine --- Medicine, Internal --- Health and hygiene
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