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The rapid evolution in cardiac computed tomography during the past decade has improved spatial and temporal resolution to the extent that cardiac CT is now an accepted alternative for the non-invasive interrogation of the heart. Beyond the assessment of cardiac structure and ventricular function, recent research has identified yet another promising CT application for the comprehensive diagnosis of coronary heart disease, namely the assessment of myocardial perfusion and viability. In this book, the first to be devoted to this novel application of CT, leading experts from across the world present up-to-date information and consider future directions. After short sections outlining the state of the art in the traditional applications of CT to image structure and function, the full range of CT techniques that may be employed to evaluate the myocardial blood supply are discussed in detail. Similarly, diverse CT approaches for the assessment of myocardial viability are described, with careful consideration of the available experimental and clinical evidence and the role of quantitative imaging.

Myocardial infarction --- Myocardium --- Tomography. --- Diseases. --- Cardiomyopathies --- Cardiomyopathy --- Myocardial diseases --- Myocardiopathies --- Myocardiopathy --- Heart --- Heart attack --- Heart infarction --- MI (Myocardial infarction) --- Myocardial infarct --- Infarction --- Medicine. --- Radiology. --- Cardiology. --- Medicine & Public Health. --- Imaging / Radiology. --- Diagnostic Radiology. --- Internal medicine --- Radiological physics --- Physics --- Radiation --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Diseases --- Coronary heart disease --- Radiology, Medical. --- Clinical radiology --- Radiology, Medical --- Radiology (Medicine) --- Medical physics

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This book updates clinicians on the most recent data regarding the medical management of patients of acute coronary syndrome (ACS), providing useful information and expert opinion on the large trials, international guidelines, and clinical practice. It reinforces the need for rapid intervention with pharmacologic therapies to treat and prevent coronary thromboembolism, and to prepare the patient for revascularization procedures, especially percutaneous coronary intervention. Pharmacological Treatment of Acute Coronary Syndromes describes conventional treatment – including anti-ischemic, antiplatelet and anticoagulant therapy – and discusses the clinical use of newer treatment options: the potent new P2Y12 platelet receptor inhibitors with the recently recommended ticagrelor and prasugrel, and new oral anticoagulant agents showing promise for acute management and secondary prevention in ACS. Triple therapy, while not initiated in the acute setting, may impact on future surgical and medical emergencies and their management. Also covered are the various recommendations for each of the antiplatelet and anticoagulant agents in terms of patient selection, pretreatment and timing of therapy, making this book an essential read for a wide range of health professionals.

Coronary heart disease. --- Pharmacology. --- Drug effects --- Medical pharmacology --- Coronary arteries --- Coronary arteriosclerosis --- Coronary disease --- Coronary thrombosis --- Ischemic heart disease --- Myocardial ischemia --- Diseases --- Acute coronary syndrome -- Diagnosis. --- Pharmacy. --- Medicine. --- Cardiology. --- Pharmacotherapy. --- Medicine & Public Health. --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Heart --- Type A behavior --- Physiological effect --- Chemistry --- Medicine --- Materia medica --- Pharmacology --- Internal medicine --- Drug therapy --- Pharmacotherapy --- Therapeutics --- Cardiovascular pharmacology. --- Chemotherapy.

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In the past two decades a number of studies have shown that abnormalities in the function and structure of coronary microcirculation can be detected in several cardiovascular diseases. On the basis of the clinical setting in which it occurs, coronary microvascular dysfunction (CMD) can be classified into four types: CMD in the absence of any other cardiac disease; CMD in myocardial diseases; CMD in obstructive epicardial coronary artery disease; and iatrogenic CMD. In some instances CMD represents an epiphenomenon, whereas in others it represents an important marker of risk or may contribute to the pathogenesis of myocardial ischemia, thus becoming a possible therapeutic target. This book provides an update on coronary physiology and a systematic assessment of microvascular abnormalities in cardiovascular diseases, in the hope that it will assist clinicians in prevention, detection and management of CMD in their everyday activity.

Coronary heart disease. --- Cardiovascular system --- Diseases. --- Cardiovascular diseases --- Coronary arteries --- Coronary arteriosclerosis --- Coronary disease --- Coronary thrombosis --- Ischemic heart disease --- Myocardial ischemia --- Diseases --- Medicine. --- Angiology. --- Cardiology. --- Minimally invasive surgery. --- Medicine & Public Health. --- Minimally Invasive Surgery. --- Heart --- Type A behavior --- Angiography. --- Endoscopic surgery. --- Internal medicine --- Endosurgery --- Minimal access surgery --- Minimally invasive surgery --- MIS (Minimally invasive surgery) --- Operative endoscopy --- Surgical endoscopy --- Endoscopy --- Microsurgery --- Surgery, Operative --- Blood-vessels --- Diagnosis, Radioscopic --- Radiography, Medical --- Radiography