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This unique advanced textbook provides a clear and comprehensive description of the field of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of revolutionary gene therapy strategies. In this advanced textbook, more than 25 leading scientists, world-renowned in their respective fields, come together to pro

Genetic transformation. --- Gene therapy. --- Therapy, Gene --- Genetic engineering --- Therapeutics --- Gene transfer --- Transformation (Genetics) --- Genetic recombination --- Microbial genetics --- Nucleic acids --- Transfection

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This book will contain the proceedings of the XV International Symposium on Retinal Degeneration (RD2012).  A majority of those who will speak and present posters at the meeting will contribute to this volume.  The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70.  The RD Symposium will focus on the exciting new developments aimed at understanding these diseases and providing therapies for them.  Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the “best” and “most important” meetings in the field.   The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy.   While advances in these areas of retinal degenerations will be described, there will be many new topics that either were in their infancy or did not exist at the time of the last RD Symposium, RD2010.  These include the role of inflammation and immunity, as well as other basic mechanisms, in age-related macular degeneration, several new aspects of gene therapy, and revolutionary new imaging and functional testing that will have a huge impact on the diagnosis and following the course of retinal degenerations, as well as to provide new quantitative endpoints for clinical trials.   The retina is an approachable part of the central nervous system (CNS), and there is a major interest in neuroprotective and gene therapy for CNS diseases and neurodegenerations, in general.  It should be noted that with successful and exciting initial clinical trials in neuroprotective and gene therapy, including the restoration of sight in blind children, the retinal degeneration therapies are leading the way towards new therapeutic measures for neurodegenerations of the CNS.  Many of the successes recently reported in these areas of retinal degeneration sprang from collaborations established at previous RD Symposia, and many of those will be reported at the RD2010 meeting and included in the proposed volume.  We anticipate the excitement of those working in the field and those afflicted with retinal degenerations will be reflected in the volume.

Retinal degeneration. --- Dystrophy, Retinal --- Macular degeneration --- Retina --- Retinal dystrophy --- Degeneration (Pathology) --- Degeneration --- Diseases --- Ophthalmology. --- Neurosciences. --- Geriatrics. --- Human genetics. --- Gene therapy. --- Geriatrics/Gerontology. --- Human Genetics. --- Gene Therapy. --- Medicine --- Eye --- Therapy, Gene --- Genetic engineering --- Therapeutics --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Gerontology --- Older people --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Health and hygiene

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The research described in this book represents important steps toward understanding the development of inner ear medicine and new perspectives in regenerative medicine, including efficacy in cochlear implants and various other treatments. The book depicts the mechanisms that underlie inner ear diseases, their experimental models, and proposals for new strategies to treat their symptoms. As well, the exciting future prospects for dealing with the very common problem of inner ear diseases are explained. These disorders occur among many people and include sensorineural hearing loss (SNHL), sudden deafness, senile deafness, noise-induced deafness, tinnitus, dizziness–vertigo, and Ménière’s disease. In Japan alone, there are more than 6 million deaf patients including those with middle-range deafness. There is currently no effective treatment, and regardless of the underlying cause, the damage has been considered irreversible. However, the results of recent research show that these patients actually can recover. The study of hair cells, spiral ganglion neurons, and stem cells for inner ear diseases such as SNHL, tinnitus, dizziness, and vertigo is at the forefront of regenerative medicine and may provide solutions to some of these problems. The information presented here makes this book a valuable professional reference work for all doctors and researchers in the field of otolaryngology who focus on regenerative treatments for inner ear diseases.

Labyrinth (Ear) --- Regenerative medicine --- Diseases --- Treatment. --- Medicine --- Regeneration (Biology) --- Inner ear --- Internal ear --- Ear --- Hearing --- Otorhinolaryngology. --- Head --- Gene therapy. --- Neurosciences. --- Regenerative Medicine/Tissue Engineering. --- Head and Neck Surgery. --- Gene Therapy. --- Surgery. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Therapy, Gene --- Genetic engineering --- Therapeutics --- Ear, nose, and throat diseases --- ENT diseases --- Otorhinolaryngology --- Regenerative medicine. --- Tissue engineering. --- Otolaryngologic surgery. --- Operative otolaryngology --- Otolaryngologic surgery --- Surgery, Operative --- Surgery, Orificial --- Biomedical engineering --- Tissue culture

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This book discusses the emergence of a new class of genes with a specific anticancer activity. These genes, recently defined as “Anticancer Genes”, are reviewed in individual chapters on their mode of action, the specific cell death signals they induce, and the status of attempts to translate them into clinical application. Anticancer Genes provides an overview of this nascent field, its genesis, current state, and prospect. It discusses how Anticancer Genes might lead to the identification of a repertoire of signaling pathways directed against cellular alterations that are specific for tumor cells. With contributions from experts worldwide, Anticancer Genes is an essential guide to this dynamic topic for researchers and students in cancer research, molecular medicine, pharmacology and toxicology and genetics as well as clinicians and clinical researchers interested in the therapeutic potential of this exciting new field.

Cancer --- Medical genetics. --- Biomedicine. --- Genetic aspects. --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Medical sciences --- Pathology --- Genetic disorders --- Cancer genetics --- Cancer genes --- Genetic aspects --- Medicine. --- Oncology. --- Gene therapy. --- Human genetics. --- Toxicology. --- Molecular Medicine. --- Cancer Research. --- Gene Therapy. --- Human Genetics. --- Pharmacology/Toxicology. --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Therapy, Gene --- Genetic engineering --- Therapeutics --- Tumors --- Clinical sciences --- Medical profession --- Life sciences --- Physicians --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Health Workforce --- Molecular biology. --- Cancer research. --- Pharmacology. --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Cancer research --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Physiological effect

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This book provides comprehensive coverage of smart biomaterials and their potential applications, a field that is developing at a very rapid pace. Because smart biomaterials are an emerging class of biomaterials that respond to small changes in external stimuli with large discontinuous changes in their physical properties, they have been designed to act as an “on–off” switch for, among others, bioseparation, immunoanalysis, drug delivery technologies, gene therapy, diagnostics, biosensors, and artificial muscles. After an introduction to the topic and the history of smart biomaterials, the author gives the reader an in-depth look at the properties, mechanics, and characterization of smart biomaterials including hydrogels, particles, assemblies, surfaces, fibers, and conjugates. Information on the wide range of applications for these materials follows, including drug delivery, tissue engineering, diagnostics, biosensors, bioseparation, and actuators. In addition, recent advances in shape memory biomaterials as active components of medical devices are also presented.

Smart materials. --- Biomedical materials. --- Materials science. --- Material science --- Physical sciences --- Biocompatible materials --- Biomaterials --- Medical materials --- Medicine --- Biomedical engineering --- Materials --- Biocompatibility --- Prosthesis --- Adaptive materials --- Intelligent materials --- Sense-able materials --- Biomaterials. --- Gene therapy. --- Polymers. --- Nanotechnology. --- Gene Therapy. --- Polymer Sciences. --- Soft and Granular Matter, Complex Fluids and Microfluidics. --- Polymere --- Polymeride --- Polymers and polymerization --- Macromolecules --- Molecular technology --- Nanoscale technology --- High technology --- Therapy, Gene --- Genetic engineering --- Therapeutics --- Polymers  . --- Amorphous substances. --- Complex fluids. --- Complex liquids --- Fluids, Complex --- Amorphous substances --- Liquids --- Soft condensed matter --- Bioartificial materials --- Hemocompatible materials --- Biomaterials (Biomedical materials)