Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This volume provides a state-of-the-art update on Fc Receptors (FcRs). It is divided into five parts. Part I, Old and New FcRs, deals with the long-sought-after FcµR and the recently discovered FCRL family and TRIM21. Part II, FcR Signaling, presents a computational model of FcεRI signaling, novel calcium channels, and the lipid phosphatase SHIP1. Part III, FcR Biology, addresses major physiological functions of FcRs, their glycosylation, how they induce and regulate both adaptive immune responses and inflammation, especially in vivo, FcR humanized mice, and the multifaceted properties of FcRn. Part IV, FcRs and Disease, discusses FcR polymorphism, FcRs in rheumatoid arthritis and whether their FcRs make macaques good models for studying HIV infection. In Part V, FcRs and Therapeutic Antibodies, the roles of various FcRs, including FcγRIIB and FcαRI, in the immunotherapy of cancer and autoimmune diseases using monoclonal antibodies and IVIg are highlighted. All 18 chapters were written by respected experts in their fields, offering an invaluable reference source for scientists and clinicians interested in FcRs and how to better master antibodies for therapeutic purposes.

Cell receptors --- Fc receptors --- Structure-activity relationships. --- Research. --- Immunology. --- Cell receptors. --- Medicine. --- Receptors. --- Molecular Medicine. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Binding sites (Biochemistry) --- Cell membranes --- Proteins --- Immunobiology --- Serology --- Health Workforce --- Receptors, Fc --- Lymphocytes --- Macrophages --- Structure-activity relationships (Biochemistry) --- Proteins . --- Molecular biology. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Proteids --- Polypeptides --- Proteomics --- Proteins. --- Medicine --- Biology --- Biomedical Research. --- Biological research --- Biomedical research

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Calcium ions represent Mother Nature’s ‘ion-of-choice’ for regulating fundamental physiological functions, as they initiate a new life at the time of fertilization and guide subsequent developmental and physiological functions of the human body. Calcium channels, which act as gated pathways for the movement of calcium ions across the membranes, play a central part in the initiation of calcium signals, and defects in calcium channel function have been found to result in a plethora of human diseases, referred to as the calcium channelopathies. Pathologies of Calcium Channels brings together leading international experts to discuss our current understanding of human diseases associated with the various calcium channels, from their molecular basis to potential future therapeutic targeting of calcium channels.

Calcium in the body. --- Biological transport. --- Calcium channels. --- Calcium ions. --- Membrane transport --- Medicine. --- Human physiology. --- Neurochemistry. --- Internal medicine. --- Proteins. --- Biomedicine. --- Human Physiology. --- Receptors. --- Internal Medicine. --- Passive transport, Biological --- Physiological transport --- Transport, Biological --- Diffusion --- Osmosis --- Body composition --- Calcification --- Cell receptors. --- Medicine, Internal --- Medicine --- Biochemistry --- Neurosciences --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Binding sites (Biochemistry) --- Cell membranes --- Proteins --- Human biology --- Medical sciences --- Physiology --- Human body --- Proteins . --- Proteids --- Biomolecules --- Polypeptides --- Proteomics

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Phospholipases generate lipid signaling molecules through their hydrolytic action on phospholipids and are known to regulate function of a variety of cells under normal and diseased conditions. While several physiological, biochemical and molecular techniques have identified key players involved in different disease processes, phospholipases have also emerged as critical players in the pathogenesis of a number of different diseases including cancer and heart disease. In addition, phospholipases are also implicated in such conditions as brain disorder/injury, kidney and immune cell dysfunction. Phospholipases in Health and Disease is a compilation of review articles dedicated to the study of the field with respect to biochemical and molecular mechanisms of normal and abnormal cell function. The wide range of area covered here is of interest to basic research scientists, clinicians and graduate students, who are engaged in studying pathophysiological basis of a variety of diseases. Furthermore, this book highlights the potential of the different phospholipases as therapeutic targets as well as part of prevention strategies. Twenty three articles in this book are organized in four sections that are designed to emphasize the most characterized forms of the phospholipases in mammalian cells. The first section discusses general aspect of phospholipases. Section two covers the role and function of phospholipase A in different pathophysiological conditions. The third section is focussed on phospholipase C which is believed to play a central role in transmembrane signaling. The final section covers phospholipase D which is present in a variety of different cells. The book illustrates that the activation of phospholipases is of fundamental importance in signal transduction affecting cell function. Overall, this book discusses the diverse mechanisms of phospholipase mediated signal transduction in different pathophysiological conditions and raises the possibility of specific forms of phospholipases serving as novel targets for drug development.

Phospholipases. --- Life sciences. --- Enzymology. --- Receptors. --- Biochemistry --- Enzymes --- Biosciences --- Sciences, Life --- Science --- Esterases --- Lipids. --- Medicine. --- Enzymes. --- Cell receptors. --- Neurosciences. --- Cell membranes. --- Lipidology. --- Molecular Medicine. --- Membrane Biology. --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Membranes (Biology) --- Glycocalyces --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Binding sites (Biochemistry) --- Cell membranes --- Proteins --- Biocatalysts --- Ferments --- Soluble ferments --- Catalysts --- Enzymology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Lipides --- Lipins --- Lipoids --- Biomolecules --- Steroids --- Health Workforce --- Molecular biology. --- Proteins . --- Cell membranes . --- Proteids --- Polypeptides --- Proteomics --- Molecular biochemistry --- Molecular biophysics --- Biophysics --- Systems biology --- Medicine --- Biology --- Proteins. --- Biological transport. --- Biomedical Research. --- Neuroscience. --- Membrane Trafficking. --- Research. --- Membrane transport --- Passive transport, Biological --- Physiological transport --- Transport, Biological --- Diffusion --- Osmosis --- Biological research --- Biomedical research

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

It is now well known that proteases are found everywhere, in viruses and bacteria as well as in all human, animal and plant cells, and play a role in a variety of biological functions ranging from digestion, fertilization, development to senescence and death. Under physiological conditions the ability of proteases is regulated by endogenous inhibitors. However, when the activity of proteases is not regulated appropriately, disease processes can result, as seen in Alzheimer’s disease, cancer metastasis and tumor progression, inflammation and atherosclerosis. Thus it is evident that there is an absolute need for a tighter control of proteolytic activities in different cells and tissues. Aimed at graduate students and researchers with an interest in cellular proteolytic events, Role of Proteases in Cellular Dysfunctions is the second book on Proteases in this series. The book consists of three parts in specified topics based on current literatures for a better understanding for the readers with respect to their subject-wise interests. The first section of this book covers a brief idea about the neuronal disorders and the involvement of proteases such as calpains, caspases and matrix metalloproteases (MMPs). The second section covers the deadly disease cancer and its relation to ubiquitin-proteosomal system, MMPs and serine proteases. The last section is about the role of proteases such as calpains, MMPs and serine protease as well as urokinase type plasminogen activator receptor (uPAR) in causing cardiovascular defects.

Cell metabolism. --- Cell receptors. --- Cytology. --- Neurosciences. --- Oncology. --- Proteolytic enzymes. --- Proteomics. --- Neural sciences --- Neurological sciences --- Neuroscience --- Cell biology --- Cellular biology --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Cells --- Peptide hydrolases --- Proteases --- Metabolism --- Life sciences. --- Cancer research. --- Proteins. --- Cell physiology. --- Life Sciences. --- Cell Physiology. --- Receptors. --- Cancer Research. --- Biomedicine general. --- Medical sciences --- Nervous system --- Molecular biology --- Proteins --- Hydrolases --- Tumors --- Biology --- Cytologists --- Binding sites (Biochemistry) --- Cell membranes --- Cellular control mechanisms --- Medicine. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Cell function --- Cytology --- Physiology --- Proteins . --- Biomedicine, general. --- Health Workforce --- Cancer research --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Cancer. --- Medicine --- Protein Biochemistry. --- Cell Biology. --- Cancer Biology. --- Neuroscience. --- Biomedical Research. --- Research. --- Biological research --- Biomedical research --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors