Listing 1 - 10 of 27 | << page >> |
Sort by
|
Choose an application
"Systematic Evidence Reviews to Answer Health Care Questions provides accessible, concise information about the state-of-the-art methods of systematic review, from key question formulation and selecting evidence to assessing the quality of included studies and reporting results. Key topics are organized around essential steps in conducting reviews as well as important issues or dilemmas encountered during the process. Although the state-of-the-art methods serve as core material, the book also presents different approaches that are sometimes needed when basic rules do not apply. Its perspective is practical and patient-centered. The book incorporates information from sources representing standards in the field, as well as from teaching and training materials developed at the Oregon Evidence-based Practice Center. Examples from existing projects are used to illustrate specific issues throughout the book. Medical practice guidelines, health care policies, and insurance coverage decisions are increasingly informed by evidence from clinical trials and other research of the benefits, harms, and comparisons of treatments, tests, and procedures. Systematic reviews provide a scientific approach to collecting and synthesizing biomedical information to answer questions that are essential to developing these guidelines and policies. However, standards for conducting systematic reviews have been lacking, and translation of evidence to practice has often been derailed when researchers hand off their systematic reviews to users who are unfamiliar with how to effectively use them. Several types of systematic reviews have evolved depending on the scope and goals of the review, such as technology assessments, comparative effectiveness reviews, and state-of-the-science reviews, for example. Although the different types of systematic reviews have much in common, they also vary in important ways. Each review requires methods appropriate to the specific clinical and health care questions it addresses, its scope, and the existing body of research. For example, a comparative effectiveness review of two or more medications previously studied in several high-quality randomized controlled trials would most likely use methods of statistical meta-analysis to pool trials to compare medications. In contrast, a state-of-the-science review to determine if specific symptoms are related to a health condition would qualitatively synthesize results of observational studies. As with all research, investigators are confronted with many decisions during the course of conducting a systematic evidence review. While investigators need to embrace the standards and accepted methodology of the discipline, they must also approach each question as unique in order to achieve meaningful results."--Provided by publisher.
Biology --- Medicine --- Health Workforce --- Biological research --- Biomedical research --- Research. --- Biomedical Research --- Review Literature as Topic --- Medical care --- Systematic reviews (Medical research)
Choose an application
How the NIH Can Help You Get Funded takes a novel, non-formulaic approach in teaching readers how to ""write a grant"" -- and much more. The authors draw on their decades of experience working with both investigators and NIH personnel to anticipate their questions and concerns and help establish a comfortable, productive partnership between them. With this book's focus on applying this knowledge to their personal grant strategy, readers will learn: DT how the NIH operates at the corporate level, as well as the culture and policies of individual institutes and centers DT how the NIH budget evol
Medicine --- Biology --- Life sciences --- Biomass --- Life (Biology) --- Natural history --- Biological research --- Biomedical research --- Health Workforce --- Research. --- Research --- National Institutes of Health (U.S.)
Choose an application
This book presents an innovative concept for the realization of sensors based on a planar metamaterial microwave array and shows their application in biomedical analysis and treatment. The sensors are able to transduce the dielectric properties of materials in their direct vicinity into an electric signal. The specific array organization permits a simultaneous analysis of several materials using a single readout signal or a relative characterization of one material where information about its spatial distribution can be extracted. Two applications of the designed sensors are described here: the first is a cytological screening using micro fluidic technology, which shows that the sensors may be integrated into lab-on-chip technologies; the second application regards the use of the sensor in both the analysis and treatment of organic tissues. The developed sensor is able not only to screen the tissues for abnormalities, but also, by changing the applied signals, to perform thermal ablation and treat the abnormalities in a highly focused way. Thus, the research described in this book represents a considerable advancement in the field of biomedical microwave sensing. .
Metamaterials --- Microwaves --- Biology --- Research. --- Biological research --- Biomedical research --- Hertzian waves --- Electric waves --- Electromagnetic waves --- Geomagnetic micropulsations --- Radio waves --- Shortwave radio --- Meta materials --- Composite materials --- Electromagnetism --- Microwaves. --- Optical materials. --- Biomedical engineering. --- Microwaves, RF and Optical Engineering. --- Optical and Electronic Materials. --- Biomedical Engineering and Bioengineering. --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Optics --- Materials --- Optical engineering. --- Electronic materials. --- Electronic materials --- Mechanical engineering
Choose an application
This volume explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease and psychiatry. Additional chapters focus on methodology as well as new technologies and instrumentation. This volume provides readers with a comprehensive and informative manual that will allow them to appreciate mass spectrometry and proteomic research but also to initiate and improve their own work. Thus the book acts as a technical guide but also a conceptual guide to the newest information in this exciting field. Mass spectrometry is the central tool used in proteomic research today and is rapidly becoming indispensable to the biomedical scientist. With the completion of the human genome project and the genomic revolution, the proteomic revolution has followed closely behind. Understanding the human proteome has become critical to basic and clinical biomedical research and holds the promise of providing comprehensive understanding of human physiological processes. In addition, proteomics and mass spectrometry are bringing unprecedented biomarker discovery and are helping to personalize medicine.
Mass spectrometry. --- Biology --- Medicine --- Research. --- Chemistry. --- Proteomics. --- Mass Spectrometry. --- Biomedicine general. --- Mass spectra --- Mass spectrograph --- Mass spectroscopy --- Mass spectrum analysis --- Mass (Physics) --- Nuclear spectroscopy --- Spectrum analysis --- Molecular biology --- Proteins --- Physical sciences --- Biomedical research --- Medical research --- Biological research --- Medicine. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Biomedicine, general.
Choose an application
The Invasive Cytopathologist: Ultrasound Guided Fine-Needle Aspiration of Superficial Masses provides a comprehensive review of the cytology of superficial neoplastic and non-neoplastic disease processes obtained by percutaneous ultrasound guidance, particularly of thyroid, parathyroid, lymph nodes, salivary glands, breast, and soft tissue with ultrasound image and histopathology correlation. This book emphasizes the basic ultrasound characteristics of thyroid nodules, the cytology of common and uncommon neoplastic and non-neoplastic processes according to the Bethesda System for Reporting Thyroid Cytopathology, and provides a technical guide for how to perform ultrasound-guided FNA of thyroid nodules to obtain adequate material for diagnosis. The volume also briefly reviews the molecular aspects of thyroid neoplasia useful for targeted therapy. The Invasive Cytopathologist: Ultrasound Guided Fine-Needle Aspiration of Superficial Masses is a useful guide for ultrasound evaluation, cytological interpretation and differential diagnostic considerations of superficial masses, and is a valuable source of information for cytopathologists, cytopathology fellows, cytotechnology students and upper level pathology residents. Endocrinologists, thyroidologists, head and neck specialists, and any professional with interest in ultrasound and fine needle aspiration cytology of superfial masses will benefit from this book.
Needle biopsy. --- Aspiration biopsy --- Biopsy, Needle --- Fine-needle aspiration biopsy --- Needle aspiration biopsy --- Puncture biopsy --- Suction biopsy --- Biopsy --- Cytodiagnosis --- Paracentesis --- Pathology. --- Medical laboratories. --- Gastroenterology. --- Laboratory Medicine. --- Internal medicine --- Digestive organs --- Diagnosis, Laboratory --- Health facilities --- Laboratories --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine --- Medicine, Preventive --- Laboratory medicine. --- Gastroenterology . --- Clinical medicine --- Clinical pathology --- Diagnostic laboratory tests --- Laboratory diagnosis --- Laboratory medicine --- Medical laboratory diagnosis --- Diagnosis --- Pathology --- Biology --- Biomedical Research. --- Research. --- Biological research --- Biomedical research --- Health Workforce
Choose an application
This volume provides a state-of-the-art update on Fc Receptors (FcRs). It is divided into five parts. Part I, Old and New FcRs, deals with the long-sought-after FcµR and the recently discovered FCRL family and TRIM21. Part II, FcR Signaling, presents a computational model of FcεRI signaling, novel calcium channels, and the lipid phosphatase SHIP1. Part III, FcR Biology, addresses major physiological functions of FcRs, their glycosylation, how they induce and regulate both adaptive immune responses and inflammation, especially in vivo, FcR humanized mice, and the multifaceted properties of FcRn. Part IV, FcRs and Disease, discusses FcR polymorphism, FcRs in rheumatoid arthritis and whether their FcRs make macaques good models for studying HIV infection. In Part V, FcRs and Therapeutic Antibodies, the roles of various FcRs, including FcγRIIB and FcαRI, in the immunotherapy of cancer and autoimmune diseases using monoclonal antibodies and IVIg are highlighted. All 18 chapters were written by respected experts in their fields, offering an invaluable reference source for scientists and clinicians interested in FcRs and how to better master antibodies for therapeutic purposes.
Cell receptors --- Fc receptors --- Structure-activity relationships. --- Research. --- Immunology. --- Cell receptors. --- Medicine. --- Receptors. --- Molecular Medicine. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Binding sites (Biochemistry) --- Cell membranes --- Proteins --- Immunobiology --- Serology --- Health Workforce --- Receptors, Fc --- Lymphocytes --- Macrophages --- Structure-activity relationships (Biochemistry) --- Proteins . --- Molecular biology. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Proteids --- Polypeptides --- Proteomics --- Proteins. --- Medicine --- Biology --- Biomedical Research. --- Biological research --- Biomedical research
Choose an application
This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology. Topics include pre-biology; the establishment of the genetic code; isomerization of RNA; damage of nucleobases in RNA; the dynamic structure of nucleic acids and their analogs in DNA replication, extra- and intra-cellular transport; molecular crowding by the use of ionic liquids; new technologies enabling the modification of gene expression via editing of therapeutic genes; the use of riboswitches; the modification of mRNA cap regions; new approaches to detect appropriately modified RNAs with EPR spectroscopy and the use of parallel and high-throughput techniques for the analysis of the structure and new functions of nucleic acids. This volume discusses how chemistry can add new frontiers to the field of nucleic acids in molecular medicine, biotechnology and nanotechnology and is not only an invaluable source of information to chemists, biochemists and life scientists but will also stimulate future research.
Molecular biology --- Nucleic acids --- Polynucleotides --- Biomolecules --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Systems biology --- Nucleic acids. --- Medicine. --- Human genetics. --- Nucleic Acid Chemistry. --- Molecular Medicine. --- Human Genetics. --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Clinical sciences --- Medical profession --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Molecular biology. --- Biomaterials. --- Medicine --- Biology --- Medical genetics. --- Nucleic Acid. --- Biomedical Research. --- Medical Genetics. --- Research. --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Genetic disorders --- Biological research --- Biomedical research --- Genetic aspects
Choose an application
This volume provides a set of reviews dedicated to the biology of Interleukin (IL)-10. It includes chapters on its importance for maintaining immune homeostasis in humans, its role in intestinal immunity and its functions during viral and bacterial infections. In addition, it presents reviews on the mechanisms linking innate microbial recognition to the production of IL-10 and on how IL-10 recognition by its receptor functions. The roles of T and B cells as relevant sources of IL-10 are also discussed, with an emphasis on the clinical opportunities offered by IL-10-producing Tr1 cells for the suppression of unwanted immunity. Finally, the functions of other cytokines of the IL-10 family are presented. Collectively, these articles provide a comprehensive overview of our current knowledge on one of the most important anti-inflammatory cytokines known to date.
Interleukin-10. --- IL-10 (Biomolecule) --- Interleukins --- Immunology. --- Cytokines. --- Medicine. --- Cytokines and Growth Factors. --- Molecular Medicine. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Cellular immunity --- Immune response --- Immunobiology --- Serology --- Regulation --- Health Workforce --- Growth factors. --- Molecular biology. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Cell growth factors --- Cellular growth factors --- Growth peptides --- Growth promoting substances --- Growth substances --- Peptide growth factors --- Peptide regulatory factors --- Polypeptide growth factors --- Cytokines --- Peptides --- Medicine --- Biology --- Biomedical Research. --- Research. --- Biological research --- Biomedical research
Choose an application
The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA inhibition. It was he who pointed out the importance of both the charged and uncharged character of these compounds for physiological experiments. The field of study that focuses on carbonic anhydrase (CA) has exploded in recent years with the identification of new families and isoforms. The CAs are metalloenzymes which are comprised of 5 structurally different families: the alpha, beta, gamma, and delta, and epsilon classes. The alpha class is found primarily in animals with several isoforms associated with human disease. The beta CAs are expressed primarily in plants and are the most divergent. The gamma CAs are the most ancient. These are structurally related to the beta CAs, but have a mechanism more similar to the alpha CAs. The delta CAs are found in marine algae and diflagellates. The epsilon class is found in prokaryotes in which it is part of the carboxysome shell perhaps supplying RuBisCO with CO2 for carbon fixation. With the excitement surrounding the discovery of disease-related CAs, scientists have redoubled their efforts to better understand structure-function relationships, to design high affinity, isotype-specific inhibitors, and to delineate signaling systems that play regulatory roles over expression and activity. We have designed the book to cover basic information of mechanism, structure, and function of the CA families. The authors included in this book bring to light the newest data with regard to the role of CA in physiology and pathology, across phylums, and in unique environmental niches.
Carbonic anhydrase. --- Lyases. --- Desmolases --- Carbonate dehydratase --- Medicine. --- Medical genetics. --- Proteins. --- Biomedicine. --- Gene Function. --- Protein Science. --- Biomedicine general. --- Enzymes --- Lyases --- Zinc enzymes --- Biochemistry. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Genetic disorders --- Composition --- Genetic aspects --- Health Workforce --- Proteins . --- Biomedicine, general. --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Medicine --- Medical Genetics. --- Protein Biochemistry. --- Biomedical Research. --- Research. --- Biological research --- Biomedical research
Choose an application
This book summarizes the state-of-the art in the development of T cell-based in vitro assays, which offer useful tools for hazard identification, risk assessment and improvement of diagnostics. It will be of interest to scientists, the chemical and pharmaceutical industry, and regulators involved in the replacement of animal testing methods. The identification of hazardous chemicals and drugs is essential to ensuring human health. The ban on animal testing for the cosmetics industry since 2009 and international efforts to reduce and replace animal testing in research and immunotoxicology call for alternative in vitro methods. The most specific immune response to chemicals and drugs that cause allergic contact dermatitis, respiratory disease and adverse drug reactions is the highly antigen-specific T lymphocyte response. Therefore the use of T cells as tools for identifying contact allergens and drugs that may cause health problems is of great interest.
Immunology. --- Medical laboratories. --- Medicine. --- Clinical sciences --- Medical profession --- Immunobiology --- Laboratory medicine. --- Molecular biology. --- Biomedicine. --- Molecular Medicine. --- Laboratory Medicine. --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Serology --- Diagnosis, Laboratory --- Health facilities --- Laboratories --- Health Workforce --- Clinical medicine --- Clinical pathology --- Diagnostic laboratory tests --- Laboratory diagnosis --- Laboratory medicine --- Medical laboratory diagnosis --- Diagnosis --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Medicine --- Biology --- Biomedical Research. --- Research. --- Biological research --- Biomedical research
Listing 1 - 10 of 27 | << page >> |
Sort by
|