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This handbook discusses developments and the future of gout treatment, which looks promising. Gout has been a well-known disease for over 2000 years, and is the most common cause of joint inflammation in adult males. It has become apparent that no therapeutic target based on hyperuricemia outcome had been defined. Very few controlled trials were available to test the efficacy and safety of treatments, and no research on diagnosis and management had been done despite data showing that patients with gout were generally improperly treated even in the hands of specialists. In the last 10 years, good-quality evidence on gout impact and management has grown exponentially, renal transporters have been recently identified, and a number of new drugs have been approved or are under current development.

Gout --- Diagnosis. --- Treatment. --- Podagra --- Arthritis --- Metabolism, Inborn errors of --- Rheumatism --- Rheumatology. --- Orthopedics. --- Pharmacotherapy. --- Orthopaedics --- Orthopedia --- Surgery --- Internal medicine --- Connective tissues --- Joints --- Diseases --- Drug therapy --- Pharmacotherapy --- Therapeutics --- Drugs --- Pharmacology

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This book presents the current evidence and practice in the pharmacological treatment of atrial fibrillation (AF). AF management has changed significantly in recent years as a new era has begun for the prevention of stroke, one of the most devastating complications of AF. Prevention of ischemic stroke in AF patients with oral anticoagulants represents a huge challenge and the enormous amount of research is revealing new treatment opportunities at a dizzying pace. While new classes of antithrombotic drugs for AF treatment are still in their infancy, recent research is revealing how these can be applied with optimal efficacy. Atrial Fibrillation Therapy includes practical information for readers on applying the guidelines developed as a result of the increased pharmacotherapeutic understanding. This book also guides trainees, recertifying physicians, and practicing physicians in internal medicine, cardiology, emergency medicine, and clinical pharmacology to apply the new diagnostic tools for selecting the best treatment options for AF patients. Discusses new diagnostic tools for selecting therapies for AF patients Presents recent research in a highly practical, easy reference style Emphasis on a just-the-facts approach to the treatment options in AF.

Atrial fibrillation. --- Cardiology. --- Auricular fibrillation --- Atrial fibrillation -- Surgery. --- Catheter ablation. --- Medicine. --- Pharmacotherapy. --- Medicine & Public Health. --- Atrial arrhythmias --- Heart --- Internal medicine --- Diseases --- Drug therapy --- Pharmacotherapy --- Therapeutics --- Drugs --- Pharmacology

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This concise, clinically focused pocket handbook assembles and synthesizes the latest developments and trends in the diagnosis and treatment of CML and provides an authoritative and convenient summary of the latest progress in TKI trials, the molecular monitoring of CML responses, and the development of new therapies to overcome resistance and improve patient care. Chronic myeloid leukemia (CML) is a rare type of leukemia (1–2 per 100,000 people) but is the most common chronic myeloproliferative neoplasm. CML remains a key model for the improved understanding of the pathophysiology of a malignancy at a molecular level; CML was the first cancer to be associated with a recurring chromosome abnormality, which generates the Philadelphia (Ph) chromosome and its associated fusion gene BCR-ABL1. The clinical outcome for patients with CML has changed dramatically in the past 15 years and this has been due to the development of tyrosine kinase inhibitors (TKIs), compounds that inhibit the activity of the oncogenic BCR-ABL1 protein. A number of first-, second- and third-generation TKIs are now available for the treatment of CML, although a number of treatment challenges remain, not least the development of treatment-resistant CML. Parallel to the development of specific drugs for treating CML, major advances have been made in the field of disease monitoring and standardization of response criteria. .

Chronic myeloid leukemia --- Chronic granulocytic leukemia --- Chronic myelocytic leukemia --- Chronic myelogenous leukemia --- CML (Disease) --- Chronic leukemia --- Myeloid leukemia --- Hematology. --- Oncology  . --- Oncology. --- Pharmacotherapy. --- Tumors --- Haematology --- Internal medicine --- Blood --- Diseases --- Drug therapy --- Pharmacotherapy --- Therapeutics --- Drugs --- Pharmacology

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This practical manual presents the main drugs and protocols currently used in the psychopharmacological treatment of psychiatric disorders in cancer and palliative care settings and explores the principal issues involved in such treatment. Significant clinical challenges encountered in the psychopharmacological management of various psychiatric conditions are discussed, covering aspects such as side-effects and drug-drug interactions. Attention is also paid to the emerging theme of adjuvant use of psychotropic drugs for the treatment of symptoms or syndromes not primarily related to psychiatric disorders (e.g. pain, hot flashes). In addition, practical suggestions are provided for dealing with special populations, including children, the elderly, and people affected by severe mental illness. The book is designed to be easy to read and to reference: information is clearly displayed in concise tables and boxes, accompanied by further detail within the text and clinical vignettes. The authors include some of the most renowned  clinicians working in the field of psycho-oncology. .

Psychopharmacology --- Oncology --- Palliative treatment --- Palliation (Medical care) --- Palliative care --- Palliative medicine --- Therapeutics --- Psychopharmacology. --- Oncology  . --- Pain Medicine. --- Oncology. --- Pharmacotherapy. --- Medicine --- Tumors --- Behavioral pharmacology --- Drugs --- Chemotherapy --- Pharmacology --- Psychotropic drugs --- Psychotropic effects --- Algiatry --- Pain medicine. --- Drug therapy --- Pharmacotherapy

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This book updates clinicians on the most recent data regarding the medical management of patients of acute coronary syndrome (ACS), providing useful information and expert opinion on the large trials, international guidelines, and clinical practice. It reinforces the need for rapid intervention with pharmacologic therapies to treat and prevent coronary thromboembolism, and to prepare the patient for revascularization procedures, especially percutaneous coronary intervention. Pharmacological Treatment of Acute Coronary Syndromes describes conventional treatment – including anti-ischemic, antiplatelet and anticoagulant therapy – and discusses the clinical use of newer treatment options: the potent new P2Y12 platelet receptor inhibitors with the recently recommended ticagrelor and prasugrel, and new oral anticoagulant agents showing promise for acute management and secondary prevention in ACS. Triple therapy, while not initiated in the acute setting, may impact on future surgical and medical emergencies and their management. Also covered are the various recommendations for each of the antiplatelet and anticoagulant agents in terms of patient selection, pretreatment and timing of therapy, making this book an essential read for a wide range of health professionals.

Coronary heart disease. --- Pharmacology. --- Drug effects --- Medical pharmacology --- Coronary arteries --- Coronary arteriosclerosis --- Coronary disease --- Coronary thrombosis --- Ischemic heart disease --- Myocardial ischemia --- Diseases --- Acute coronary syndrome -- Diagnosis. --- Pharmacy. --- Medicine. --- Cardiology. --- Pharmacotherapy. --- Medicine & Public Health. --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Heart --- Type A behavior --- Physiological effect --- Chemistry --- Medicine --- Materia medica --- Pharmacology --- Internal medicine --- Drug therapy --- Pharmacotherapy --- Therapeutics --- Cardiovascular pharmacology. --- Chemotherapy.