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In this volume, the major metabolic alterations identified in cancer and tumor-associated cells are explored, including discussions of former and emerging approaches to drug development in targeting cancer cell metabolism.  The metabolic network in cells promotes the generation of both energy and biomass needed for them to grow, divide and differentiate.  However, the metabolism of malignant cells generally varies from that of normal cells.  These differences provide a platform for the discovery of new approaches to targeting potential vulnerabilities in cancer cells for therapeutic options  Some of the significant changes that occur involve ATP production and consumption that modulates the ATP to ADP ratio, hypoxia and the effects of reactive oxygen species on glycolysis, regulation of mitochondrial respiration, induction and suppression of autophagy, and the Warburg effect and “reverse” Warburg effect--these topics and more are discussed in this volume.  .

Tumor antigens. --- Tumors -- Immunological aspects. --- Tumors. --- Metabolic Phenomena --- Drug Discovery --- Diseases --- Chemistry, Pharmaceutical --- Phenomena and Processes --- Investigative Techniques --- Chemistry --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Pharmacology --- Natural Science Disciplines --- Biological Science Disciplines --- Disciplines and Occupations --- Drug Design --- Neoplasms --- Metabolism --- Metabolome --- Biology --- Medicine --- Health & Biological Sciences --- Cytology --- Oncology --- Cell metabolism. --- Cancer cells --- Metabolism. --- Growth. --- Cancer cell growth --- Cells --- Medicine. --- Cancer research. --- Molecular biology. --- Pharmacology. --- Biomedicine. --- Cancer Research. --- Metabolomics. --- Molecular Medicine. --- Pharmacology/Toxicology. --- Anabolism --- Catabolism --- Metabolism, Primary --- Primary metabolism --- Biochemistry --- Physiology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Molecular biochemistry --- Molecular biophysics --- Biophysics --- Biomolecules --- Systems biology --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Physiological effect --- Pathology, Cellular --- Cellular control mechanisms --- Oncology. --- Toxicology. --- Poisoning --- Poisons --- Tumors --- Toxicology --- Health Workforce --- Cancer --- Research.