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This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers recent research and methods development for changing the DNA sequence within the genomes of cells and organisms. Focusing on enzymes that generate double-strand breaks in DNA, the chapters describe use of molecular tools to introduce or delete genetic information at specific sites in the genomes of animal, plant and bacterial cells.Continues the legacy of this premier serial with quality chapters authored by leaders in the fieldCovers r
Esterases --- Computational Biology --- DNA Restriction-Modification Enzymes --- Endodeoxyribonucleases --- Genetic Techniques --- Genetics --- Deoxyribonucleases --- Enzymes --- Hydrolases --- Biology --- Investigative Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Biological Science Disciplines --- Enzymes and Coenzymes --- Natural Science Disciplines --- Chemicals and Drugs --- Disciplines and Occupations --- DNA Restriction Enzymes --- Genomics --- Endonucleases --- Genetic Engineering --- Health & Biological Sciences --- Genomics. --- Genome research --- Genomes --- Research --- Molecular genetics
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Phospholipases generate lipid signaling molecules through their hydrolytic action on phospholipids and are known to regulate function of a variety of cells under normal and diseased conditions. While several physiological, biochemical and molecular techniques have identified key players involved in different disease processes, phospholipases have also emerged as critical players in the pathogenesis of a number of different diseases including cancer and heart disease. In addition, phospholipases are also implicated in such conditions as brain disorder/injury, kidney and immune cell dysfunction. Phospholipases in Health and Disease is a compilation of review articles dedicated to the study of the field with respect to biochemical and molecular mechanisms of normal and abnormal cell function. The wide range of area covered here is of interest to basic research scientists, clinicians and graduate students, who are engaged in studying pathophysiological basis of a variety of diseases. Furthermore, this book highlights the potential of the different phospholipases as therapeutic targets as well as part of prevention strategies. Twenty three articles in this book are organized in four sections that are designed to emphasize the most characterized forms of the phospholipases in mammalian cells. The first section discusses general aspect of phospholipases. Section two covers the role and function of phospholipase A in different pathophysiological conditions. The third section is focussed on phospholipase C which is believed to play a central role in transmembrane signaling. The final section covers phospholipase D which is present in a variety of different cells. The book illustrates that the activation of phospholipases is of fundamental importance in signal transduction affecting cell function. Overall, this book discusses the diverse mechanisms of phospholipase mediated signal transduction in different pathophysiological conditions and raises the possibility of specific forms of phospholipases serving as novel targets for drug development.
Phospholipases. --- Life sciences. --- Enzymology. --- Receptors. --- Biochemistry --- Enzymes --- Biosciences --- Sciences, Life --- Science --- Esterases --- Lipids. --- Medicine. --- Enzymes. --- Cell receptors. --- Neurosciences. --- Cell membranes. --- Lipidology. --- Molecular Medicine. --- Membrane Biology. --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Membranes (Biology) --- Glycocalyces --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Binding sites (Biochemistry) --- Cell membranes --- Proteins --- Biocatalysts --- Ferments --- Soluble ferments --- Catalysts --- Enzymology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Lipides --- Lipins --- Lipoids --- Biomolecules --- Steroids --- Health Workforce --- Molecular biology. --- Proteins . --- Cell membranes . --- Proteids --- Polypeptides --- Proteomics --- Molecular biochemistry --- Molecular biophysics --- Biophysics --- Systems biology --- Medicine --- Biology --- Proteins. --- Biological transport. --- Biomedical Research. --- Neuroscience. --- Membrane Trafficking. --- Research. --- Membrane transport --- Passive transport, Biological --- Physiological transport --- Transport, Biological --- Diffusion --- Osmosis --- Biological research --- Biomedical research
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This volume focuses on recent advances in the biochemical and molecular analysis of different families of phospholipases in plants and their roles in signaling plant growth, development, and responses to abiotic and biotic cues. The hydrolysis of membrane lipids by phospholipases produces different classes of lipid mediators, including phosphatidic acid, diacylglycerol, lysophospholipids, free fatty acids, and oxylipins. Phospholipases are grouped into different families and subfamilies according to their site of hydrolysis, substrate usage, and sequence similarities. Activating one or more of these enzymes often constitutes an early, critical step in many regulatory processes, such as signal transduction, vesicular trafficking, secretion, and cytoskeletal rearrangements. Lipid-based signaling plays pivotal roles in plant stress responses, cell size, shape, growth, apoptosis, proliferation, and reproduction.
Lipids -- Physiology. --- Plant lipids. --- Plants -- Chemistry. --- Human Anatomy & Physiology --- Botany --- Health & Biological Sciences --- Earth & Environmental Sciences --- Plant Physiology --- Animal Biochemistry --- Phospholipases. --- Plant cell interaction. --- Life sciences. --- Plant biochemistry. --- Lipids. --- Plant pathology. --- Plant physiology. --- Life Sciences. --- Plant Physiology. --- Plant Biochemistry. --- Lipidology. --- Plant Pathology. --- Cell interaction --- Plant cellular control mechanisms --- Esterases --- Biochemistry. --- Plant diseases. --- Communicable diseases in plants --- Crop diseases --- Crops --- Diseases of plants --- Microbial diseases in plants --- Pathological botany --- Pathology, Vegetable --- Phytopathology --- Plant pathology --- Plants --- Vegetable pathology --- Agricultural pests --- Crop losses --- Diseased plants --- Phytopathogenic microorganisms --- Plant pathologists --- Plant quarantine --- Lipides --- Lipins --- Lipoids --- Biomolecules --- Steroids --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Physiology --- Pathology --- Diseases and pests --- Diseases --- Wounds and injuries --- Composition --- Phytochemistry --- Plant biochemistry --- Plant chemistry --- Biochemistry --- Phytochemicals --- Plant biochemical genetics --- Plant cellular signal transduction.
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