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The main scope of this topic is to give an update on pharmacologic and non-pharmacologic approaches to enhance uptake and penetration of cancer drugs into tumors. Inadequate accumulation of drugs in tumors has emerged over the last decade as one of the main problems underlying therapeutic failure and drug resistance in the treatment of cancer.

Neoplasms. --- Tumors. --- Oncology. --- Cancer --- Drug testing. --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Tumors --- Neoplasms --- Tumours --- Pathology --- Cysts (Pathology) --- Oncology --- Resistance --- microenvironment --- Administration --- targeting --- Penetration --- Drug delivery --- Permeability --- Junctions --- Integrins