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Pathogenic bacteria. --- Bacterial diseases --- Drug resistance in microorganisms. --- Chemotherapy --- Evaluation.
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Drug resistance in microorganisms --- Antibiotics --- Bacterial diseases --- Research --- Treatment
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"Technological Challenges in Antibiotic Discovery and Development is the summary of a workshop convened by the Chemical Sciences Roundtable in September 2013 to explore the current state of antibiotic discovery and examine the technology available to facilitate development. Through formal presentations and panel discussions, participants from academia, industry, federal research agencies discussed the technical challenges present and the incentives and disincentives industry faces in antibiotic development, and identified novel approaches to antibiotic discovery. Antibiotic resistance is a serious and growing problem in modern medicine and it is emerging as a pre-eminent public health threat. Each year in the United States alone, at least two million acquire serious infections with bacteria that are resistant to one or more antibiotics, and at least 23,000 people die annually as a direct result of these antibiotic-resistant infections. In addition to the toll on human life, antibiotic-resistant infections add considerable and avoidable costs to the already overburdened U.S. health care system. This report explores the challenges in overcoming antibiotic resistance, screening for new antibiotics, and delivering them to the sites of infection in the body. The report also discusses a path forward to develop the next generation of potent antimicrobial compounds capable of once again tilting the battle against microbial pathogens in favor of humans. Technological Challenges in Antibiotic Discovery and Development gives a broad view of the landscape of antibiotic development and the technological challenges and barriers to be overcome."--Publisher's description
Drug resistance in microorganisms --- Public health --- Antibiotics --- Research
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Beschrijving van het belang van lichaamseigen bacteriën voor onze gezondheid en de nadelen van het verkeerde en overmatige gebruik van antibiotica in verband daarmee. We worden dikker, zijn vaker allergisch voor bepaald voedsel, kampen met astma, hooikoorts, brandend maagzuur en prikkelbare darmen, en kinderen krijgen steeds vaker de diagnose autisme. Deze chronische ziekten zijn niet makkelijk te genezen en hebben grote invloed op de kwaliteit van ons leven. Ze zijn waarschijnlijk ontstaan doordat bepaalde soorten bacteriën, die ons al eeuwenlang beschermen tegen schadelijke invloeden, langzaam uitsterven. Volgens Martin Blaser heeft dat vooral te maken met een overmatig gebruik van antibiotica. Krijgen we deze middelen te snel voorgeschreven? Krijgen we er te veel van binnen via dierlijke producten zoals vlees, kaas, eieren en melk?
Bacteriën. --- Antibioticagebruik. --- Antibiotics --- Effectiveness --- Drug resistance in microorganisms --- Bacteriën --- Biologie --- Immuunsysteem --- Bacterie
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Antimicrobial therapy is a key factor in our success against pathogens poised to ravage at risk or infected individuals. However, we are currently at a watershed point as we face a growing crisis of antibiotic resistance among diverse pathogens. One area of intense interest is the impact of the application of antibiotics for uses other than the treatment of patients and the association with such utilization with emerging drug resistance. This Research Topic “Low dose antibiotics: current status and outlook for the future” in Frontiers in Microbiology: Antimicrobials, Resistance and Chemotherapy details various aspects of the wide ranging effects of antimicrobial therapy from areas such as the regulation of host responses tomodulation of bacterial virulence factors to acquisition of antibiotic resistance genes.
Antibiotics --- Drug resistance in microorganisms. --- Effectiveness. --- Research. --- growth promotion --- Immunomodulatory effect --- feed additives --- low dose antibiotics --- antibiotics --- Environmental impact
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Antimicrobial therapy is a key factor in our success against pathogens poised to ravage at risk or infected individuals. However, we are currently at a watershed point as we face a growing crisis of antibiotic resistance among diverse pathogens. One area of intense interest is the impact of the application of antibiotics for uses other than the treatment of patients and the association with such utilization with emerging drug resistance. This Research Topic “Low dose antibiotics: current status and outlook for the future” in Frontiers in Microbiology: Antimicrobials, Resistance and Chemotherapy details various aspects of the wide ranging effects of antimicrobial therapy from areas such as the regulation of host responses tomodulation of bacterial virulence factors to acquisition of antibiotic resistance genes.
Antibiotics --- Drug resistance in microorganisms. --- Effectiveness. --- Research. --- growth promotion --- Immunomodulatory effect --- feed additives --- low dose antibiotics --- antibiotics --- Environmental impact
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Antimicrobial therapy is a key factor in our success against pathogens poised to ravage at risk or infected individuals. However, we are currently at a watershed point as we face a growing crisis of antibiotic resistance among diverse pathogens. One area of intense interest is the impact of the application of antibiotics for uses other than the treatment of patients and the association with such utilization with emerging drug resistance. This Research Topic “Low dose antibiotics: current status and outlook for the future” in Frontiers in Microbiology: Antimicrobials, Resistance and Chemotherapy details various aspects of the wide ranging effects of antimicrobial therapy from areas such as the regulation of host responses tomodulation of bacterial virulence factors to acquisition of antibiotic resistance genes.
Antibiotics --- Drug resistance in microorganisms. --- growth promotion --- Immunomodulatory effect --- feed additives --- low dose antibiotics --- antibiotics --- Environmental impact --- Effectiveness. --- Research.
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"The Institute of Medicine launched an innovative outreach program in 1988. Through the generosity of the Rosenthal Family Foundation (formerly the Richard and Hinda Rosenthal Foundation), a discussion series was created to bring greater attention to some of the significant health policy issues facing our nation today. Each year a major health topic is addressed through remarks and conversation between experts in the field. The IOM later publishes the proceedings from this event for the benefit of a wider audience. This volume summarizes remarks by and an engaging discussion with Dr. Rima Khabbaz, Dr. Stuart Levy, Dr. Margaret (Peg) Riley, and Dr. Brad Spellberg on "Antimicrobial Resistance: A Problem Without Borders." The Centers for Disease Control and Prevention identified antimicrobial resistance as one of five urgent health threats facing the United States this year. Antimicrobial resistance is a global health security threat that will demand collaboration from many stakeholders around the world. This report highlights the crosscutting character of antimicrobial resistance and the needs for many disciplines to be brought together to be able to deal with it more effectively."--
Drug resistance in microorganisms -- Congresses. --- Drug resistance in microorganisms --- Antibacterial agents --- Medical policy --- Public Policy --- Microbiological Phenomena --- Anti-Infective Agents --- Social Control Policies --- Phenomena and Processes --- Therapeutic Uses --- Policy --- Pharmacologic Actions --- Social Sciences --- Chemical Actions and Uses --- Chemicals and Drugs --- Anthropology, Education, Sociology and Social Phenomena --- Drug Resistance, Microbial --- Anti-Bacterial Agents --- Health Policy --- Biology --- Health & Biological Sciences --- Microbiology & Immunology
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This WHO report produced in collaboration withMember States and other partners provides as accuratea picture as is presently possible of the magnitude ofAMR and the current state of surveillance globally.The report focuses on antibacterial resistance (ABR)in common bacterial pathogens. Why? There is amajor gap in knowledge about the magnitude of thisproblem and such information is needed to guideurgent public health actions. ABR is complex andmultidimensional. It involves a range of resistancemechanisms affecting an ever-widening range ofbacteria most of which can cause a wide spectrumof disea
Drug resistance -- Periodicals. --- Drug resistance in microorganisms. --- Drug resistance. --- Anti-infective agents --- Drug resistance in microorganisms --- Risk management --- Risk --- Risk Management --- Information Science --- Drug Resistance --- Microbiological Phenomena --- Epidemiologic Measurements --- Therapeutic Uses --- Probability --- Pharmacologic Actions --- Pharmacological Phenomena --- Public Health --- Organization and Administration --- Statistics as Topic --- Health Services Administration --- Environment and Public Health --- Chemical Actions and Uses --- Physiological Phenomena --- Health Care Evaluation Mechanisms --- Health Care --- Epidemiologic Methods --- Drug Therapy. --- Quality of Health Care --- Investigative Techniques --- Diagnostic Techniques and Procedures. --- Health Care Quality, Access, and Evaluation --- Anti-Infective Agents --- Classification --- Risk Assessment --- Drug Resistance, Microbial --- Effect of drugs on
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