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Pancreas --- Endothelial Cells --- Cell Differentiation --- Acinar cells

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The second edition of Stem Cells: Scientific Facts and Fiction provides the non-stem cell expert with an understandable review of the history, current state of affairs, and facts and fiction of the promises of stem cells. Building on success of its award-winning preceding edition, the second edition features new chapters on embryonic and iPS cells and stem cells in veterinary science and medicine. It contains major revisions on cancer stem cells to include new culture models, additional interviews with leaders in progenitor cells, engineered eye tissue, and xeno organs from stem cell

Cell differentiation. --- Stem cell research. --- Stem cells -- Physiology. --- Stem cells. --- Stem cells --- Embryonic stem cells --- Cell differentiation --- Biomedical Research --- Cells --- Investigative Techniques --- Research --- Anatomy --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Science --- Natural Science Disciplines --- Disciplines and Occupations --- Stem Cell Research --- Stem Cells --- Biology --- Health & Biological Sciences --- Cytology --- Research.

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This book uses the juvenile mammalian brain as a starting point to describe how different injury mechanisms influence neuronal and glial progenitor response to injury, and how in certain circumstances, these cells might play adaptive or harmful roles in recovery.  It also provides an overview of emerging concepts in progenitor biology and how current understanding of the processes regulating these cells has tempered some of the initial enthusiasm regarding their therapeutic potential. Only recently has significant effort been devoted to the study of late neurogenesis in mammals, though this interesting phenomenon was first described over fifty years ago.  In many settings, injury accelerates the ongoing neurogenesis now known to occur, and recently described reservoirs of glial progenitors add to the pool of existing reparative possibilities.  Dr. Steven G. Kernie is an Associate Professor of Pediatrics and Pathology & Cell Biology at Columbia University in New York and Chief of Critical Care Medicine at Morgan Stanley Children’s Hospital at Columbia University Medical Center. His laboratory is interested in how the brain repairs itself following injury. The presence of adult neural stem and progenitor cells in the mammalian brain has awakened new interest and optimism in potential treatment for a variety of acquired brain disorders. The Kernie lab is investigating how adult neural stem and progenitor cells participate in injury-induced remodeling and in identifying genes and drugs that might be important in augmenting their contribution. In order to do this, they have generated a variety of transgenic mice that allow for temporally controlled alterations in the endogenous stem cell population in order to optimize the post-injury remodeling that occurs. Dr. Marie-Pierre Junier is Research Director at Inserm and co-PI of team Glial Plasticity for the Center of Research Neuroscience Paris Seine at the University Pierre et Marie Curie. Her team showed the permissiveness of astrocytes to re-programming into immature states akin to neural progenitors or neural stem cells. It further demonstrated that these plastic capabilities of astrocytes sensitize them to cancerous transformation. The team is now using cancer stem cells isolated from human adult and pediatric gliomas to understand their differences from normal human neural stem cells. Combining proteomic, metabolic and epigenetic approaches, the team aims at developing new therapeutic strategies against these devastating cancers.

Brain -- growth & development. --- Brain. --- Cell. --- Stem cells --- Biological Science Disciplines --- Cells --- Vertebrates --- Biological Processes --- Nervous System --- Cell Differentiation --- Chordata --- Biological Phenomena --- Anatomy --- Cell Physiological Processes --- Natural Science Disciplines --- Phenomena and Processes --- Disciplines and Occupations --- Animals --- Cell Physiological Phenomena --- Eukaryota --- Organisms --- Stem Cells --- Mammals --- Central Nervous System --- Regeneration --- Neurogenesis --- Physiology --- Biology --- Health & Biological Sciences --- Cytology --- Research --- Stem cells. --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Life sciences. --- Cancer research. --- Neurosciences. --- Neurochemistry. --- Cell biology. --- Life Sciences. --- Stem Cells. --- Cell Biology. --- Cancer Research. --- Cell biology --- Cellular biology --- Cytologists --- Biochemistry --- Neurosciences --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Cancer research --- Biosciences --- Sciences, Life --- Science --- Cytology. --- Oncology. --- Tumors