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Pathophysiological states, neurological and psychiatric diseases are almost universally considered from the neurocentric point of view, with neurons being the principal cellular element of pathological process. The brain homeostasis, which lies at the fulcrum of healthy brain function, the compromise of which invariably results in dysfunction/disease, however, is entirely controlled by neuroglia. It is becoming clear that neuroglial cells are involved in various aspects of initiation, progression and resolution of neuropathology.  In this book we aim to integrate the body of information that has accumulated in recent years revealing the active role of glia in such pathophysiological processes.  Understanding roles of glial cells in pathology will provide new targets for medical intervention and aide the development of much needed therapeutics. This book will be particularly useful for researchers, students, physicians and psychotherapists working in the field of neurobiology, neurology and psychiatry.

Neuroglia. --- Nervous system --- Diseases. --- Medical neurology --- Nerves --- Neurologic disorders --- Neurological disorders --- Neuropathology --- Neurology --- Glial cells --- Nerve tissue --- Diseases --- Neurosciences. --- Neurochemistry. --- Neurology. --- Psychiatry. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Medicine and psychology --- Mental health --- Psychology, Pathological --- Medicine --- Neuropsychiatry --- Biochemistry --- Neurosciences --- Neurology .

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ATP was naturally selected very early on as the main source of biological energy, and thus became an indispensable feature of life on the Earth. This was a critical evolutionary choice because it shaped enzymatic systems to utilize ATP in energy-dependent reactions and necessitated an appearance of the universal intracellular signaling system based on calcium ions; keeping cytosolic Ca2+ extremely low became vitally important, since otherwise insoluble Ca2+-phosphates would preclude the cell energetics. Thus, all living cells on the Earth, beginning from the most primitive ones, had high cytosolic concentrations of ATP and there is little surprise that ATP was soon utilized by nature for another fundamental function of sending information from one living cell to another. In summary, ATP acts as the main energy source and is pivotal for numerous signaling cascades both inside (by fueling various transport systems and donating phosphate groups) and between the cells (by chemical transmission). Similarly, glutamate acts as an important molecule for both intercellular signaling through glutamatergic transmission and cell energetics by contributing to ATP production. In this collection of chapters, written by the leading experts in the fields of cell metabolism and energetics, intracellular signaling and neurotransmission, we covered various aspects of the interfacing between these two fundamental molecules. This book will be particularly useful for researchers, students, physicians and psychotherapists working in the field of neurobiology, neurology and psychiatry.

Glutamic acid --- Adenosine triphosphate --- Metabolism. --- Adenosinetriphosphate --- Adenosinetriphosphoric acid --- Adenylpyrophosphate --- ATP (Biochemistry) --- Adenine nucleotides --- Phosphates --- Glutamate --- Excitatory amino acids --- Umami (Taste) --- Neurosciences. --- Neurobiology. --- Neurosciences --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system