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While steroids from the periphery have profound effects on the nervous system, the nervous system also produces its own steroids de novo (“neurosteroids”). The physiological importance of neurosteroids is beginning to be understood. These steroids potentially have roles in sedative/hypnotic behavior, anxiety, learning, and memory. At the cellular level, neurosteroids affect neuronal excitability, synaptic plasticity and cell proliferation and survival. Early findings hold promise for future strategies to treat specific psychologicalconditions and neurological diseases. This Brief will focus on the current state of understanding of brainderived neurosteroids.

Neuroendocrinology. --- Steroid hormones. --- Neurohormones. --- Hormonal steroids --- Neuroendocrinology --- Neurohormones --- Medicine. --- Neurosciences. --- Neurochemistry. --- Biomedicine. --- Biochemistry --- Neurosciences --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Hormones --- Steroids --- Endocrinology --- Neurology

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The prevalence of hypertension is almost three times as high as that of diabetes mellitus type 2, with both conditions being major risk factors for stroke, ischemic heart disease, cardiac arrhythmias, and heart failure.  The exact prevalence of hypertension related to hormonal derangements (endocrine hypertension) is not known but estimated to affect less than 15% of hypertensive patients.  Recent scientific discoveries have increased the understanding of the pathophysiologic mechanisms of hypertension.  In Endocrine Hypertension, a renowned panel of experts provides a comprehensive, state-of-the-art overview of this disorder, discussing when to assign an endocrine cause in one of  many conditions that may present with hypertension.   The first part of Endocrine Hypertension is dedicated to adrenal causes.  The second part of the volume concerns potential nonadrenal causes of hypertension, such as growth hormone excess or deficiency, primary hyperparathyroidism, vitamin D deficiency, testosterone deficiency, insulin resistance, obesity-associated hypertension, and the role of central mineralocorticoid receptors and cardiovascular disease. An important contribution to the literature, Endocrine Hypertension is an indispensable reference not only for endocrinologists, diabetologists, and adrenal investigators, but also for translational scientists and clinicians from cardiology, internal medicine, pediatrics, family medicine, geriatrics, urology, and reproductive medicine / gynecology.

Hypertension --- Adrenocortical hormones --- Adrenal glands --- Adrenals --- Suprarenal bodies --- Suprarenal capsules --- Adrenal cortex hormones --- Adrenal steroids --- Adrenocorticoids --- Corticoids --- Corticosteroids --- Blood pressure, High --- High blood pressure --- Vascular hypertension --- Endocrine aspects. --- Physiological effect. --- Diseases --- Complications. --- Medicine. --- Obstetrics. --- Internal medicine. --- Cardiology. --- Endocrinology. --- Nephrology. --- Urology. --- Medicine & Public Health. --- Internal Medicine. --- Obstetrics/Perinatology. --- Adrenal cortex --- Steroid hormones --- Blood circulation disorders --- Endocrine glands --- Kidneys --- Obstetrics/Perinatology/Midwifery. --- Maternal-fetal medicine --- Medicine --- Heart --- Internal medicine --- Medicine, Internal --- Hormones --- Genitourinary organs --- Endocrinology .

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Androgen Deficiency and Testosterone Replacement: Current Controversies and Strategies explores the difficulties around the diagnosis and treatment of androgen deficiency. The text examines the available evidence concerning the diagnosis and treatment of men with low testosterone. It also examines controversies in the identification and management of these men. While the information contained within will be of use to those who specialize in androgen deficiency and sexual medicine, the scope of the book will serve as a source of basic information about testosterone replacement and as a source of reasoned analysis of the controversies surrounding testosterone replacement in the aging male. Physicians and physician extenders will be able to apply evidence management principles to the evaluation and treatment of men with testosterone deficiency; supported by the most recent practice guidelines available. The authors represent a select group of physicians with expertise in androgen deficiency and replacement.  Androgen Deficiency and Testosterone Replacement: Current Controversies and Strategies will be of great value to all physicians and physician extenders who deliver health care to men of all ages. .

Androgens. --- Endocrinology. --- Testosterone. --- Testosterone --- Androgens --- Gonadal Disorders --- Hormones --- Testosterone Congeners --- Androstenols --- Endocrine System Diseases --- Gonadal Steroid Hormones --- Hormones, Hormone Substitutes, and Hormone Antagonists --- Androstenes --- Diseases --- Physiological Effects of Drugs --- Androstanes --- Gonadal Hormones --- Steroids --- Pharmacologic Actions --- Polycyclic Compounds --- Chemical Actions and Uses --- Chemicals and Drugs --- Hypogonadism --- Medicine --- Health & Biological Sciences --- Urology & Nephrology --- Pharmacy, Therapeutics, & Pharmacology --- Therapeutic use --- Physiological effect --- Physiological effect. --- Medicine. --- Urology. --- Medicine & Public Health. --- Medicine/Public Health, general. --- Genitourinary organs --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce

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This volume provides a brief résumé of the history of testosterone research, from the early pioneers through to the most recent advances in the field. We discover how steroid hormones were first identified and how testosterone was shown to be essential for male development. Moving forward we explore how and where testosterone is produced, and how the body controls testosterone production. We then investigate the impact testosterone has on different body systems both during their development and function, and how perturbation of testosterone action is associated with disease. We complete our story with an exploration of the emerging roles of testosterone in clinical therapy, and the future potential for manipulation of the testosterone signaling system for human health benefit.

Cell therapy. --- Esophagoscopy. --- Medicine. --- Testosterone --- Biological Science Disciplines --- Hormones --- Metabolic Phenomena --- Receptors, Steroid --- Testis --- Androstenols --- Receptors, Cytoplasmic and Nuclear --- Genitalia, Male --- Natural Science Disciplines --- Androstenes --- Phenomena and Processes --- Hormones, Hormone Substitutes, and Hormone Antagonists --- Physiological Effects of Drugs --- Androstanes --- DNA-Binding Proteins --- Genitalia --- Disciplines and Occupations --- Steroids --- Urogenital System --- Proteins --- Pharmacologic Actions --- Amino Acids, Peptides, and Proteins --- Chemical Actions and Uses --- Polycyclic Compounds --- Anatomy --- Chemicals and Drugs --- Physiology --- Metabolism --- Androgens --- Leydig Cells --- Receptors, Androgen --- Medicine --- Health & Biological Sciences --- Gynecology & Obstetrics --- Cellular therapy. --- Cell therapy --- Cells --- Therapy, Cellular --- Bouginage, Esophageal --- Esophagoscopic bouginage --- Therapeutic use --- Endocrinology. --- Reproductive medicine. --- Cell biology. --- Medicine & Public Health. --- Reproductive Medicine. --- Cell Biology. --- Organotherapy --- Therapeutics, Physiological --- Transplantation of organs, tissues, etc. --- Cell transplantation --- Endoscopy --- Esophagus --- Examination --- Cytology. --- Cell biology --- Cellular biology --- Biology --- Cytologists --- Internal medicine --- Human reproduction --- Human reproductive health --- Human reproductive medicine --- Reproductive medicine --- Health --- Health aspects --- Endocrinology .