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A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years. In particular recent new avenues regarding the role of stem cells and microRNAs along with further understanding of the importance of angiogenesis, immunotherapy and explanations for the resistance of the tumors to chemotherapeutic agents and radiation therapy has been developed. It is hopeful that this new information will lead to efficacious treatment strategies for these tumors which remain a challenge. In this book a review of the latest information on these topics along with a variety of new therapeutic treatment strategies with an emphasis on molecular targeted therapies is provided.

Brain --- Neoplasms. --- Tumors. --- Cerebrum --- Mind --- Central nervous system --- Head --- Oncology

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"Osborn's brain : imaging, pathology, and anatomy is the much-pleaded-for successor to Anne G. Osborn's 1993 award winning book Diagnostic neuroradiology (a.k.a. "The red book"), which became one of the all-time bestselling neuroradiology texts. In this highly anticipated 1,200-page volume, Anne Osborn applies her special touch to make complex topics visually appealing and easy to understand. It wraps the "must know" aspects of brain imaging together with spectacular pathology examples, relevant anatomy, and the most up-to-date modalities and techniques in brain imaging"-- Provided by publisher

Brain --- Central Nervous System Diseases --- Neuroimaging --- physiopathology --- pathology --- methods --- physiopathology. --- pathology. --- methods. --- Physiopathology. --- Pathology. --- Methods. --- Brain - physiopathology --- Central Nervous System Diseases - pathology --- Neuroimaging - methods --- Central nervous system --- Cerveau --- Système nerveux central --- Radiography. --- Diseases. --- Imaging. --- Physiopathologie. --- Maladies. --- Imagerie. --- Pathophysiology.

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Cerebral ischemia from cardiac arrest, stroke, and subarachnoid and intracerebral hemorrhage, together with trauma, epilepsy, and other CNS pathologies, continue to impose immense burdens of morbidity and mortality the world over. Despite many decades of research aimed at understanding the genetic and molecular basis of these pathologies, therapeutics developed on the basis of blocking ‘known’ injury mechanisms can actually claim few clinical successes. The field of CNS “preconditioning” was born from the preclinical finding more than 20 years ago that intentional activation of innate, cytoprotective factors could provide robust protection, or “tolerance” against cerebral ischemic injury.  Herein, up-to-date summaries on all aspects of preconditioning for CNS disease, including the emerging topics of postconditioning and remote pre- and post-conditioning, are provided by the leading scientists in the field. The translational potential of both preclinical and clinical advances is underscored throughout, with the hope of accelerating the bench-to-bedside success of endogenous cytoprotection as a therapeutic strategy.   Jeffrey M. Gidday PhD, Associate Professor of Neurosurgery at Washington University School of Medicine, has been working in the field of CNS preconditioning for 18 years, and has numerous publications on preconditioning-induced protection in the setting of several different cerebral and retinal pathologies.  Miguel A. Perez-Pinzon PhD is Professor of Neurology/Neuroscience, Vice-Chair for Basic Science of Neurology at the University of Miami Miller School of Medicine. He began studies of ischemic preconditioning in 1995 and for many years prior to that worked in the field of anoxia tolerance, publishing close to 50 peer-reviewed articles and many book chapters on these topics. John H. Zhang MD PhD is Professor of Neurosurgery, Anesthesiology, and Physiology, and Vice-Chair of the Basic Science Department at the Loma Linda University School of Medicine. His research interests include stroke and medical gases, and he has published papers related to pre-, post- and remote-conditioning in subarachnoid hemorrhage, focal cerebral ischemia, and neonatal brain injury.

Central nervous system -- Diseases. --- Central nervous system diseases -- Therapy. --- Neuroprotective agents. --- Neuroprotective agents --- Investigative Techniques --- Cerebrovascular Disorders --- Protective Agents --- Therapeutics --- Central Nervous System Agents --- Therapeutic Uses --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Physiological Effects of Drugs --- Vascular Diseases --- Brain Diseases --- Pharmacologic Actions --- Central Nervous System Diseases --- Cardiovascular Diseases --- Chemical Actions and Uses --- Nervous System Diseases --- Diseases --- Chemicals and Drugs --- Brain Ischemia --- Methods --- Ischemic Postconditioning --- Neuroprotective Agents --- Ischemic Preconditioning --- Medicine --- Human Anatomy & Physiology --- Health & Biological Sciences --- Neurology --- Neuroscience --- Central nervous system. --- Central nervous system --- Cerebral ischemia. --- Diseases. --- Brain ischemia --- Nervous system, Central --- Neurosciences. --- Neurology. --- Neurobiology. --- Cerebrovascular disease --- Ischemia --- Nervous system --- Neurosciences --- Neuropsychiatry --- Neural sciences --- Neurological sciences --- Medical sciences --- Neurology .

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Brain --- Cognition disorders --- Cognitive disorders --- Psychology, Pathological --- Cerebrum --- Mind --- Central nervous system --- Head --- Wounds and injuries --- Patients --- Rehabilitation --- Evaluation

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Neuro-oncology is one of the most exciting and rapidly evolving areas of oncology. In recent years there has been a remarkable increase in activity in the field, from basic science through to the clinic. This is reflected by advances in the understanding of the biology of CNS malignancies which have informed the development of novel and successful therapies.  In this environment it is essential to facilitate communication and understanding of new ideas and concepts.   Emerging Concepts in Neuro-Oncology is written with this in mind: to encourage collaboration across traditional boundaries and promote translational research for patient benefit. The book moves from concepts in the scientific basis of neuro-oncology in part one, through models of brain cancer in part two, to emerging concepts in clinical practice in part three, with a focus on translational research.   This book will be an essential read for neuroscience researchers, cancer researchers, neurosurgeons and clinical oncologists as well as anyone with an interest in this exciting, dynamic field.

Brain -- Tumors. --- Central nervous system -- Cancer. --- Central nervous system -- Tumors. --- Medicine. --- Brain --- Central nervous system --- Brain Diseases --- Neoplasms, Neuroepithelial --- Internal Medicine --- Central Nervous System Neoplasms --- Nervous System Neoplasms --- Neoplasms, Glandular and Epithelial --- Neuroectodermal Tumors --- Central Nervous System Diseases --- Medicine --- Nervous System Diseases --- Neoplasms, Germ Cell and Embryonal --- Neoplasms by Site --- Neoplasms by Histologic Type --- Health Occupations --- Neoplasms, Nerve Tissue --- Disciplines and Occupations --- Diseases --- Neoplasms --- Glioma --- Brain Neoplasms --- Medical Oncology --- Health & Biological Sciences --- Oncology --- Tumors --- Cancer --- Molecular aspects --- Cancer. --- Tumors. --- Cancer research. --- Neurosciences. --- Oncology. --- Neurology. --- Medicine & Public Health. --- Cancer Research. --- Oncology  . --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Neuropsychiatry --- Neurology . --- Cancer research