Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

La maladie de Parkinson est caractérisée par une perte des neurones dopaminergiques, ce qui entraine une perte des transporteurs de la dopamine (DaT) dans le striatum. Son diagnostic est essentiellement clinique mais cependant il peut être difficile surtout au stade précoce de la maladie et chez les patients ne présentant pas les symptômes classiques. Récemment, le DaTSCAN, un radioligand du DaT a été mis sur le marché. Couplé à la tomographie d'émission monophotonique (TEMP), il permet de visualiser la quantité de DaT encore présente. Le but de ce travail était d'évaluer l'intérêt du DaTSCAN dans le diagnostic et le suivi de la maladie de Parkinson. Dans une étude réalisée chez des patients avec un diagnostic clinique incertain, en prenant comme référence le diagnostic clinique posé à 36 mois, l'imagerie au DaTSCAN a montré une sensibilité de 78% et une spécificité de 97% système dopaminergique, ce qui soutient le diagnostic de la maladie de Parkinson, du parkinsonisme atypique ou de la démence à corps de Lewy. Tandis qu'une image normale indique qu'il n'y a pas de neurodégénérescence et qu'il ne s'agit pas de la maladie de Parkinson mais bien des syndromes parkinsoniens tels que le tremblement essentiel ou le parkinsonisme iatrogène. Cependant, l'imagerie au DaTSCAN ne permet pas le diagnostic différentiel entre la maladie de Parkinson et les formes de parkinsonisme atypique. Enfin, en plus de ses applications en pratique clinique, le DaTSCAN pourrait s'avérer intéressant dans le cadre d'études évaluant les traitements neuroprotecteurs. Une étude réalisée chez 20 patients au stade précoce de la maladie de Parkinson a démontré que le DaTSCAN pouvait mesurer le taux de progression de la dégénérescence dopaminergique. La diminution de la captation du radiotraceur (et donc la perte neuronale) a été estimée à 8% par an. Parkinson's disease is characterized by degeneration of dopaminergic neurons, resulting in loss of dopamine transporters in the striatum. The diagnosis of Parkinson's disease is mainly clinical but it can be very challenging, especially in the early stage of the disease and in patients who have not classic symptoms. Recently, DaTSCAN, a radioligand of the DaT was licensed. Using single-photon emission computed tomography (SPECT), it allows to visualize the amount of DaT present. The aim of this work was to assess the benefit of DaTSCAN on the diagnosis and monitoring of Parkinson's disease. In patient with clinically uncertain parkinsonism , baseline imaging with DaTSCAN has shown 78% sensitivity and 97% specificity with reference to clinical diagnosis at 36 months, versus 93%and 46%, respectively, for baseline clinical diagnosis. Abnormal imaging indicates neurodegeneration of dopaminergic system, supportive of a diagnosis of Parkinson's disease, atypical parkinsonism or dementia with Lewy bodies. Normal imaging supports diagnosis of a condition not involving neurodegeneration such as essential tremor or drug-induced parkinsonism. However, DaTSCAN is not helpful in differentiating between Parkinson's disease and atypical parkinsonism. Finally, in addition to its application in clinical practice, DaTSCAN might be interesting in the context of studies evaluating the neuroprotective treatments. A study of 20 patients with early Parkinson's disease showed that DaTSCAN could measure the rate of dopaminergic degeneration's progression. The annual decrease in striatal DaTSCAN binding was about 8%.

Parkinson Disease --- Tomography, Emission-Computed

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The overall goal of this book is to promote research and development of imaging and radioanalytical techniques by publishing high-quality chapters in this rapidly growing interdisciplinary field. This book discusses the principles and applications of imaging and radioanalytical techniques across a wide spectrum of interdisciplinary science, technology and medicine, where these techniques are expected to make significant difference and contribution. It also explores the history of the field, current trends, and future directions. The book focuses mainly on cutting-edge applications, and associated equipments and methods, such as instrumentation systems and computing hardware/software. The primary target audience for this book includes students, researchers, clinicians, and professionals who are interested in medical and ground penetrating radar (GPR) imaging, and radioanalytical techniques.

Tomography. --- Body section radiography --- Computed tomography --- Computer tomography --- Computerized tomography --- CT (Computed tomography) --- Laminagraphy --- Laminography --- Radiological stratigraphy --- Stratigraphy, Radiological --- Tomographic imaging --- Zonography --- Cross-sectional imaging --- Radiography, Medical --- Geometric tomography --- Medical imaging

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This new project on PET/MR imaging in oncology includes digital interactive software matching the cases in the book. The interactive version of the atlas is based on the latest web standard, HTML5, ensuring compatibility with any computer operating system as well as a dedicated version for Apple iPad and iPhone. The book opens with an introduction to the principles of hybrid imaging that pays particular attention to PET/MR imaging and standard PET/MR acquisition protocols. A wide range of illustrated clinical case reports are then presented. Each case study includes a short clinical history, findings, and teaching points, followed by illustrations, legends, and comments. The multimedia version of the book includes dynamic movies that allow the reader to browse through series of rotating 3D images (MIP or volume rendered), display blending between PET and MR, and dynamic visualization of 3D image volumes. The movies can be played either continuously or sequentially for better exploration of sets of images. The editors of this state-of-the-art publication are key opinion leaders in the field of multimodality imaging. Professor Osman Ratib (Geneva) and Professor Markus Schwaiger (Munich) were the first in Europe to initiate the clinical adoption of PET/MR imaging. Professor Thomas Beyer (Zurich) is an internationally renowned pioneering physicist in the field of hybrid imaging. Individual clinical cases presented in this book are co-authored by leading international radiologists and nuclear physicians experts in the use of PET and MRI.

Cancer -- Magnetic resonance imaging -- Atlases. --- Cancer -- Tomography -- Atlases. --- Tomography, Emission -- Atlases. --- Medicine --- Health & Biological Sciences --- Radiology, MRI, Ultrasonography & Medical Physics --- Cancer --- Tomography, Emission --- Magnetic resonance imaging --- Imaging --- Computerized emission tomography --- Emission tomography --- PET (Tomography) --- PET-CT (Tomography) --- Positron emission tomography --- Positron emission transaxial tomography --- Radionuclide tomography --- Scintigraphy, Tomographic --- Tomography, Radionuclide --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Medicine. --- Radiology. --- Nuclear medicine. --- Oncology. --- Medicine & Public Health. --- Imaging / Radiology. --- Nuclear Medicine. --- Diagnosis --- Diagnostic imaging --- Positrons --- Radioisotope scanning --- Tumors --- Data processing --- Emission --- Radiology, Medical. --- Oncology  . --- Clinical radiology --- Radiology, Medical --- Radiology (Medicine) --- Medical physics --- Atomic medicine --- Radioisotopes in medicine --- Medical radiology --- Radioactive tracers --- Radioactivity --- Physiological effect --- Radiological physics --- Physics --- Radiation --- Tomography

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

CT imaging has become a mainstay of medical imaging. After 30 years this is a mature technology but the accumulation of innovations over the past decades have given it extraordinary capabilities and new applications continue to emerge. In this book Alex Mamourian uses early CT technology to explain the fundamentals of CT imaging and then builds on that base to explain how innovations such as slip-ring and multidetector arrays allow for rapid, high resolution imaging. This book covers complex applications such as CT cardiac imaging and dual-source dual-energy CT scanning as well as the pitfalls

Tomography. --- Nervous system --- Radiation dosimetry. --- Radiation --- Whole body imaging. --- Heart --- Cardiographic tomography --- Whole body scanning --- Whole body screening --- Diagnostic imaging --- Radiation monitoring --- Radiation protection --- Dosimetry --- Nuclear counters --- Neuroradiography --- Neuroradiology --- Body section radiography --- Computed tomography --- Computer tomography --- Computerized tomography --- CT (Computed tomography) --- Laminagraphy --- Laminography --- Radiological stratigraphy --- Stratigraphy, Radiological --- Tomographic imaging --- Zonography --- Cross-sectional imaging --- Radiography, Medical --- Geometric tomography --- Radiography. --- Safety measures. --- Diseases --- Tomography --- Radiography --- Dosage --- Measurement

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This handbook, written in a clear and precise style, describes the principles of positron emission tomography (PET) and provides detailed information on its application in clinical practice. The first part of the book explains the physical and biochemical basis for PET and covers such topics as instrumentation, image reconstruction, and the production and diagnostic properties of radiopharmaceuticals. The focus then turns to the use of PET in clinical practice, including its role in hybrid imaging (PET-CT). A wide range of oncological applications are discussed, including for cancers of the head and neck, breast, lung, digestive system, urinary tract, female reproductive system, and prostate, lymphoproliferative disorders, melanoma, and musculoskeletal tumors. Uses of PET in cardiology, neurology, and psychiatry are also addressed. Characteristic findings are described and illustrated by numerous images, many of them in color. This book will be of value not only for nuclear medicine physicians and radiologists but also for all oncologists, surgeons, cardiologists, neurologists, psychiatrists, and residents with an interest in molecular imaging.

Tomography, Emission. --- Tomography, Emission --- Tomography, Emission-Computed --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Diseases --- Image Interpretation, Computer-Assisted --- Diagnostic Imaging --- Diagnostic Techniques and Procedures --- Positron-Emission Tomography --- Neoplasms --- Diagnosis --- Medicine --- Health & Biological Sciences --- Radiology, MRI, Ultrasonography & Medical Physics --- Diagnostic imaging. --- Clinical imaging --- Imaging, Diagnostic --- Medical diagnostic imaging --- Medical imaging --- Noninvasive medical imaging --- Computerized emission tomography --- Emission tomography --- PET (Tomography) --- PET-CT (Tomography) --- Positron emission tomography --- Positron emission transaxial tomography --- Radionuclide tomography --- Scintigraphy, Tomographic --- Tomography, Radionuclide --- Medicine. --- Radiology. --- Neuroradiology. --- Nuclear medicine. --- Oncology. --- Medicine & Public Health. --- Nuclear Medicine. --- Diagnostic Radiology. --- Diagnostic imaging --- Positrons --- Radioisotope scanning --- Diagnosis, Noninvasive --- Imaging systems in medicine --- Data processing --- Emission --- Radiology, Medical. --- Oncology  . --- Tumors --- Clinical radiology --- Radiology, Medical --- Radiology (Medicine) --- Medical physics --- Atomic medicine --- Radioisotopes in medicine --- Medical radiology --- Radioactive tracers --- Radioactivity --- Physiological effect --- Neuroradiography --- Neuroradiology --- Nervous system --- Radiological physics --- Physics --- Radiation --- Clinical Medicine.