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Cancer --- Cellular signal transduction. --- Cancer genes. --- Genetic regulation. --- Neoplasms --- Signal Transduction. --- Gene Expression. --- Gene expression --- Gene expression regulation --- Gene regulation --- Biosynthesis --- Cellular control mechanisms --- Molecular genetics --- Genes --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Information theory in biology --- Cancer genetics --- Cancer genes --- Expression, Gene --- Expressions, Gene --- Gene Expressions --- Gene Expression Profiling --- Receptor Mediated Signal Transduction --- Signal Transduction Pathways --- Signal Transduction Systems --- Cell Signaling --- Receptor-Mediated Signal Transduction --- Signal Pathways --- Pathway, Signal --- Pathway, Signal Transduction --- Pathways, Signal --- Pathways, Signal Transduction --- Receptor-Mediated Signal Transductions --- Signal Pathway --- Signal Transduction Pathway --- Signal Transduction System --- Signal Transduction, Receptor-Mediated --- Signal Transductions --- Signal Transductions, Receptor-Mediated --- System, Signal Transduction --- Systems, Signal Transduction --- Transduction, Signal --- Transductions, Signal --- Cell Communication --- Receptor-CD3 Complex, Antigen, T-Cell --- Receptor Cross-Talk --- Feedback, Physiological --- Gasotransmitters --- Genetic aspects. --- Molecular aspects. --- genetics. --- Regulation --- Genetic aspects

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This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This is the third of three volumes on hydrogen peroxide and cell signaling, and includes chapters on such topics as the biological chemistry of hydrogen peroxide, reactive oxygen species in the activation of MAP kinases, and investigating the role of reactive oxygen species in regulating autophagy. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers hydrogen peroxi

Carbon compounds. --- Cell interaction. --- Hydrogen peroxide. --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Cellular signal transduction. --- Cell-cell interaction --- Cell communication --- Cellular communication (Biology) --- Cellular interaction --- Intercellular communication --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Disinfection and disinfectants --- Peroxides --- Cellular control mechanisms --- Bioenergetics --- Information theory in biology --- Enzymology.

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Our view of plants is changing dramatically. Rather than being only slowly responding organisms, their signaling is often very fast and signals, both of endogenous and exogenous origin, spread throughout plant bodies rapidly. Higher plants coordinate and integrate their tissues and organs via sophisticated sensory systems, which sensitively screen both internal and external factors, feeding them information through both chemical and electrical systemic long-distance communication channels. This revolution in our understanding of higher plants started some twenty years ago with the discovery of systemin and rapid advances continue to be made. This volume captures the current ‘state of the art’ of this exciting topic in plant sciences.

Botany --- Earth & Environmental Sciences --- Plant Physiology --- Plant cellular signal transduction. --- Cellular signal transduction. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Life sciences. --- Plant biochemistry. --- Plant genetics. --- Plant pathology. --- Plant physiology. --- Life Sciences. --- Plant Physiology. --- Plant Biochemistry. --- Plant Genetics & Genomics. --- Plant Pathology. --- Plants --- Physiology --- Communicable diseases in plants --- Crop diseases --- Crops --- Diseases of plants --- Microbial diseases in plants --- Pathological botany --- Pathology, Vegetable --- Phytopathology --- Plant pathology --- Vegetable pathology --- Agricultural pests --- Crop losses --- Diseased plants --- Phytopathogenic microorganisms --- Plant pathologists --- Plant quarantine --- Genetics --- Phytochemistry --- Plant biochemistry --- Plant chemistry --- Biochemistry --- Phytochemicals --- Plant biochemical genetics --- Biosciences --- Sciences, Life --- Science --- Pathology --- Diseases and pests --- Diseases --- Wounds and injuries --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Cellular signal transduction --- Plant cellular control mechanisms --- Biochemistry. --- Plant diseases. --- Plant Genetics and Genomics. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Composition

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Sphingolipids are lipid components of the plasma membrane of eukaryotic cells with an important function in signaling mechanisms in the cell. This  book provides insight into the physiological and pathophysiological role of sphingolipids and in particular its derivative ceramide. The function of Sphingolipids in cell signaling with regard to infectious and lung diseases, cancer, cardiovascular diseases and neuropsychiatric disorders are described and treated in distinct parts. Together with Volume 215 from the same Editors, the collection represents a unique, comprehensive work on Sphingolipids, providing information on both: Sphingolipid basic biology  as well as its important function in a (patho)physiological context. The book is written for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians in pharmacology, oncology, cardiology, neurology and infectious disease.   .

Sphingolipids. --- Sphingolipids --- Cellular signal transduction. --- Pathophysiology. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Lipids --- Sphingosine --- Toxicology. --- Cardiology. --- Oncology. --- Immunology. --- Neurosciences. --- Lipids. --- Pharmacology/Toxicology. --- Cancer Research. --- Lipidology. --- Lipides --- Lipins --- Lipoids --- Biomolecules --- Steroids --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Immunobiology --- Life sciences --- Serology --- Tumors --- Heart --- Internal medicine --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Diseases --- Toxicology --- Pharmacology. --- Cancer research. --- Cancer research --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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Peroxisomes are a class of ubiquitous and dynamic single membrane-bounded cell organelles, devoid of DNA, with an essentially oxidative type of metabolism. Today it is known that fatty acid β-oxidation is a general feature of virtually all types of peroxisomes, but in higher eukaryotes, including humans, peroxisomes catalyze ether phospholipids biosynthesis, fatty acid α-oxidation, and glyoxylate detoxification, and in humans peroxisomes are associated with several important genetic diseases. Among the different new roles for human peroxisomes discovered in recent years are antiviral innate immunity, peptide hormone metabolism, brain aging and Alzheimer’s disease, and age-related diseases. In fungi, new findings have broadened the number of secondary metabolites that are synthesized in peroxisomes, such as antibiotics and several toxins, and have evidenced their involvement in biotin biosynthesis, fungal development and plant pathogenesis. In plants, peroxisomes carry out different functions, apart from fatty acid β-oxidation, mainly including photorespiration, metabolism of reactive oxygen, nitrogen and sulfur species, photomorphogenesis, biosynthesis of phytohormones, senescence, and defense against pathogens and hervibores. Two important characteristics of peroxisomes are their metabolic plasticity and capacity of sharing metabolic pathways with other cell compartments. In recent years, a function for peroxisomes as key centers of the cellular-signaling apparatus which could influence the regulatory network of the cell has been postulated. The diverse key physiological functions that have been demonstrated for peroxisomes from different origins strongly indicate the interest of studying the role of peroxisomes as a cellular source of different signaling molecules. This book presents recent advances in the function and metabolism of peroxisomes from human, animal, fungal and plant origin and their metabolic interconnection with other cell compartments, showing the central role played by peroxisomes as cell generators of different signaling molecules involved in distinct processes of high physiological importance.

Cellular signal transduction. --- Gene expression. --- Metabolism. --- Peroxisomes. --- Peroxisomes --- Cellular signal transduction --- Metabolism --- Peroxidosomes --- Peroxysoma --- Medicine. --- Biochemistry. --- Plant biochemistry. --- Proteomics. --- Cell biology. --- Cell physiology. --- Biomedicine. --- Biomedicine general. --- Cell Biology. --- Cell Physiology. --- Animal Biochemistry. --- Plant Biochemistry. --- Microbodies --- Cytology. --- Molecular biology --- Proteins --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Cell function --- Cytology --- Physiology --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Composition --- Health Workforce --- Biomedicine, general. --- Phytochemistry --- Plant biochemistry --- Plant chemistry --- Biochemistry --- Botany --- Phytochemicals --- Plant biochemical genetics --- Medicine --- Botanical chemistry. --- Proteins. --- Biomedical Research. --- Chemical Biology. --- Protein Biochemistry. --- Research. --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Biological research --- Biomedical research