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Sendai virus (SeV) is not just a mouse pathogen but is evolving into a cutting-edge component of biotechnology. SeV reverse genetics originating from a pure academic need to settle long-held questions in the biology and pathogenicity of nonsegmented negative strand RNA viruses (Mononegavirales) is about to bear the impressive fruit of multipurpose cytoplasmic (non-integrating) RNA vectors. This book brings together in one source the SeV biology revealed by conventional approaches and reverse genetics, the methods to construct the first-generation SeV vector and to generate safer versions, and the applications in medical settings that have left or are about to leave the laboratory bench. The applications, which already are diverse and have high medical impact, include use as vaccine vectors against AIDS and respiratory virus infections, creation of BioKnife to resect malignant tumors, induction of “footprint (transgene) free” pluripotent stem cells, and gene therapy for peripheral arterial disease. These achievements—which are just a few of many examples—were attainable only after rigorously incorporating the rich knowledge of SeV biology that has accumulated during the several decades since the discovery of the virus. Application of SeV vector is certain to expand greatly because of its extremely high performance in transgene expression and its remarkable target cell breadth.

Sendai virus. --- Genetic Structures --- Respirovirus --- Paramyxovirinae --- Genetic Phenomena --- Phenomena and Processes --- Paramyxoviridae --- Mononegavirales --- RNA Viruses --- Viruses --- Vertebrate Viruses --- Organisms --- Genetic Vectors --- Sendai virus --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- RNA viruses --- Biotechnology. --- Genetics. --- Riboviruses --- Viruses, RNA --- Hemagglutinating virus of Japan --- Influenza D virus --- Para-influenza virus type 1 --- Parainfluenza virus type 1 --- Medicine. --- Gene expression. --- Gene therapy. --- Virology. --- Biomedicine. --- Gene Therapy. --- Gene Expression. --- Chemical engineering --- Genetic engineering --- Parainfluenza viruses --- Medical virology. --- Genes --- Genetic regulation --- Therapy, Gene --- Therapeutics --- Medical microbiology --- Virology --- Virus diseases --- Expression --- Microbiology

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Since their initial discovery in the 1970’s, astroviruses have been recognized as a leading cause of enteritis in infants, the elderly, and immunocompromised people, and were known to be widespread in animals and birds. In recent years, and with the advent of  pyrosequencing, there has been a virtual explosion in the number of newly identified astrovirus genotypes. With this has come an increased understanding in astrovirus biology, structure, epidemiology, immunology, and disease pathogenesis including the likelihood of extraintestinal and systemic infections. The advent of new diagnostic tests that detect all of the currently identify human astrovirus strains may prove that these viruses are more prevalent in populations than currently realized. This book will provide state-of-the-art information on our current understanding of astroviruses for researchers, medical and veterinary providers, and diagnosticians as prepared by the leaders in the respective fields. The goal is to bring the reader up to date on the state of knowledge on this constantly evolving and exciting field of virology.

Astrovirus. --- RNA Viruses --- Microbiology --- Biological Science Disciplines --- RNA Virus Infections --- Natural Science Disciplines --- Biology --- Virus Diseases --- Viruses --- Vertebrate Viruses --- Disciplines and Occupations --- Organisms --- Diseases --- Astroviridae Infections --- Virology --- Physiology --- Astroviridae --- Medicine --- Health & Biological Sciences --- Microbiology & Immunology --- Infectious Diseases --- Virus diseases --- Research. --- Viral diseases --- Viral infections --- Virus infections --- Medicine. --- Immunology. --- Medical microbiology. --- Virology. --- Infectious diseases. --- Biochemistry. --- Biomedicine. --- Medical Microbiology. --- Infectious Diseases. --- Animal Biochemistry. --- Communicable diseases --- Medical virology --- Pathogenic viruses