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Kisspeptin has been shown to be both necessary and sufficient for activation of the reproductive axis, during puberty and later in adulthood.  This makes kisspeptin a fundamental component of the reproductive axis. Kisspeptin has been deemed the single most potent stimulator of GnRH neurons yet known.  The importance of kisspeptin has been documented in humans as well as non-human animal models, ranging from monkeys, sheep, and rodents to numerous fish species, thus signifying a highly conserved nature of its reproductive function.  Importantly, kisspeptin neurons seem to mediate many of the regulatory effects of other signals, whether they are metabolic, circadian, hormonal, or stress. This places kisspeptin neurons in a unique position to be key nodal points and conduits for conveying numerous endogenous and exogenous signals to the reproductive axis.

Calcitonin gene-related peptide. --- Drug receptors. --- Serpins. --- Tumor suppressor proteins --- Reproduction --- Cellular signal transduction --- Luteinizing hormone releasing hormone --- Biochemical Processes --- Reproductive Physiological Processes --- Biological Science Disciplines --- Metabolic Phenomena --- Pituitary Hormone-Releasing Hormones --- Biochemical Phenomena --- Hypothalamic Hormones --- Natural Science Disciplines --- Phenomena and Processes --- Reproductive Physiological Phenomena --- Reproductive and Urinary Physiological Phenomena --- Chemical Phenomena --- Peptide Hormones --- Disciplines and Occupations --- Hormones --- Hormones, Hormone Substitutes, and Hormone Antagonists --- Chemicals and Drugs --- Signal Transduction --- Gonadotropin-Releasing Hormone --- Metabolism --- Physiology --- Kisspeptin neurons. --- Sex differentiatio --- Endocrine aspects. --- Kiss1 neurons --- Kisspeptin-expressing neurons --- Medicine. --- Neurosciences. --- Endocrinology. --- Reproductive medicine. --- Biomedicine. --- Biomedicine general. --- Reproductive Medicine. --- Human reproduction --- Human reproductive health --- Human reproductive medicine --- Reproductive medicine --- Health --- Internal medicine --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Health aspects --- Neurons --- Endocrinology . --- Biomedicine, general. --- Health Workforce