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Kidney transplantation is an attractive intervention for patients with end stage renal failure, it improves their quality of life and reduces also health care costs to society. On the one hand, immunosuppressive treatments used are very effective at short-term on graft rejection control. On the other hand, these ones are Jess effective at long term. The transplanted patients receive a combination of immunosuppressive drugs, it' s often a combination therapy composed by tacrolimus, mycophenolate mofetil and steroid associated with induction therapy, preferably daclizumab. The disadvantage of these molecules is their significant side effects; immunosuppression they cause makes the patient vulnerable to microorganisms. In addition, they also increase the incidence of cancer and cardiovascular problems. The transplanted patients need to be regularly monitored by a doctor to detect the occurrence of side effects and to quickly verify the treatment's effectiveness in progress. La transplantation rénale est une intervention intéressante pour les patients atteints d'insuffisance rénale au stade final, elle améliore leur qualité de vie et diminue également les coûts des soins de santé pour la société. D'une part, les traitements immunosuppresseurs utilisés sont très efficaces à court terme sur le contrôle du rejet du greffon. D'autre part, ceux­ ci sont moins efficaces à long terme. Le patient transplanté reçoit une association d'immunosuppresseurs, il s'agit souvent d'une trithérapie composée du tacrolimus, du mycophénolate mofétil et d'un corticoïde associé à un traitement d'induction, de préférence le daclizumab. L'inconvénient de ces molécules est Jeurs effets indésirables non négligeables ; l 'immunosuppression qu'ils entrainent rend les patients plus vulnérables face aux microorganismes. De plus, ils augmentent également 1'incidence de cancers et les problèmes cardiovasculaires. Les patients transplantés doivent donc être suivi régulièrement par un médecin pour détecter l 'apparition d'effets secondaires rapidement et vérifier l'efficacité du traitement en cours.

Kidney Transplantation --- Immunosuppressive Agents --- Vascularized Composite Allotransplantation

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Through case presentations and a question and answer format, Clinical Decisions in Nephrology, Hypertension and Renal Transplantation  provides a state of the art, updated reference for the optimal management of patients with diseases of the kidneys, and hypertension. This volume starts with the assessment of the patient, focusing on history and physical examination. Subsequently, cases depicting various clinical syndromes and/or diseases are presented, with questions centering on the appropriate diagnostic and treatment strategy. This sets the stage for a ‘Socratic approach’ to learning between the attending physician and the house staff or medical student. This is the only book featuring problem-oriented true to life clinical cases in this format to cover nephrology, hypertension and kidney transplantation. Written by renowned actively practicing clinicians, this unique reference is both comprehensive and concise and will be of great value to hospitalists and internists, as well as students, and interns/residents rotating in nephrology and internal medicine. Clinical practitioners, in the fields of critical care and hypertension specialists would also find this of value.

Critical care medicine. --- Internal medicine. --- Medicine. --- Nephrology. --- Hypertension --- Renal Replacement Therapy --- Organ Transplantation --- Urologic Diseases --- Urologic Surgical Procedures --- Vascular Diseases --- Male Urogenital Diseases --- Transplantation --- Urogenital Surgical Procedures --- Female Urogenital Diseases --- Therapeutics --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Diseases --- Cardiovascular Diseases --- Surgical Procedures, Operative --- Female Urogenital Diseases and Pregnancy Complications --- Kidney Transplantation --- Hypertension, Renal --- Kidney Diseases --- Medicine --- Health & Biological Sciences --- Urology & Nephrology --- Kidneys --- Diseases. --- Kidney diseases --- Nephritis --- Nephropathy --- Renal diseases --- Medicine & Public Health. --- Internal Medicine. --- Intensive / Critical Care Medicine. --- Internal medicine --- Intensive care --- Intensive medicine --- Emergency medicine --- Intensive care units --- Medicine, Internal