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Dans les années 1980, le traitement des lymphomes reposait sur la chimiothérapie de type CHOP pour les lymphomes non hodgkiniens (LNH) et de type MOPP pour les lymphomes de hodgkin (LH). La première ne permettait pas plus de 30 % de guérison pour les LNH et si la seconde thérapie s'accompagnait de 60 à 70 % de guérison pour les LH, elle entraînait des risques d'infertilité et de second cancer avec au premier plan le risque de leucémies aiguës myéloïdes.Les thérapeutiques ont considérablement évolué depuis cette époque. Dans les lymphomes non hodgkiniens, la distinction entre les lymphomes B et
Lymphomas. --- Germinoblastomas --- Immunoblastomas --- Lymphoma --- Non-Hodgkin's lymphoma --- Reticulolymphosarcomas --- Sarcoma, Germinoblastic --- Sarcoma, Immunoblastic --- Lymphoproliferative disorders --- Reticulo-endothelial system --- Tumors
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Recently, understanding the molecular pathogenesis of malignant lymphomas has led to improvement in the diagnostic precision and to the identification of a variety of molecular therapeutic targets. In addition, new drugs have been approved in the US and Europe, resulting in changes in the standard of care of several types of lymphoid malignancies. Comprehensive in scope and developed by a team of internationally renowned authors, Lymphoma: Diagnosis and Treatment provides a timely update on the most important advances in the biology, diagnosis, and therapy of lymphomas. As part of the Current Clinical Oncology series, Lymphoma: Diagnosis and Treatment will be of value to medical oncologists, hematologists, radiation oncologists, and all physicians involved in the care of patients with lymphoid malignancies.
Burkitt's lymphoma. --- Lymphomas --- Neoplasms by Histologic Type --- Neoplasms --- Diseases --- Lymphoma --- Medicine --- Health & Biological Sciences --- Oncology --- Diagnosis. --- Treatment. --- Germinoblastomas --- Immunoblastomas --- Non-Hodgkin's lymphoma --- Reticulolymphosarcomas --- Sarcoma, Germinoblastic --- Sarcoma, Immunoblastic --- Medicine. --- Cancer research. --- Hematology. --- Oncology. --- Medicine & Public Health. --- Cancer Research. --- Lymphoproliferative disorders --- Reticulo-endothelial system --- Tumors --- Oncology . --- Haematology --- Internal medicine --- Blood --- Cancer research
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The mature T and NK cell lymphomas are rare, comprising approximately 10% of all malignant lymphomas. The incidence of T-cell lymphoma is variable around the world, with a higher incidence compared to B-cell lymphomas in the Asian basin. While the overall incidence of B-cell lymphomas has begun to decline in the United States, the incidence of T-cell lymphomas continues to rise. Over the last decade, a number of novel agents have been developed which target T-cell lymphomas and studies have identified novel genes and pathways associated with lymphomagenesis in T-cells. This comprehensive volume examines the clinical and biological aspects of the T-cell lymphoproliferative disorders in adults and children. The book includes an overview of both the cutaneous and the systemic T-cell malignancies and addresses the classification of T-cell lymphomas, the clinical features of each subtype, and the relevant molecular and genetic studies. Clinical outcomes and treatment strategies are discussed with an emphasis on the development of novel biological and targeted therapies. An outstanding resource for hematologists and oncologists, this book gathers insights from experts in the field and provides the most up-to-date information on all of the T-cell lymphoma subgroups and current and emerging therapies.
Lymphomas. --- Neoplasms. --- T cells. --- Lymphomas --- Lymphoma, Non-Hodgkin --- Lymphoma --- Lymphoproliferative Disorders --- Neoplasms by Histologic Type --- Neoplasms --- Lymphatic Diseases --- Immunoproliferative Disorders --- Diseases --- Hemic and Lymphatic Diseases --- Immune System Diseases --- Lymphoma, T-Cell --- Medicine --- Health & Biological Sciences --- Oncology --- Pathology --- T lymphocytes --- Thymus-dependent cells --- Thymus-dependent lymphocytes --- Thymus-derived cells --- Germinoblastomas --- Immunoblastomas --- Non-Hodgkin's lymphoma --- Reticulolymphosarcomas --- Sarcoma, Germinoblastic --- Sarcoma, Immunoblastic --- Medicine. --- Angiology. --- Hematology. --- Oncology. --- Medicine & Public Health. --- Lymphocytes --- Lymphoproliferative disorders --- Reticulo-endothelial system --- Tumors --- Oncology . --- Angiography. --- Blood-vessels --- Diagnosis, Radioscopic --- Radiography, Medical --- Haematology --- Internal medicine --- Blood --- Radiography
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Recent developments in the therapy of non-Hodgkin lymphoma have improved response and survival rates in patients with these conditions. This book is focused on the biology, prognostic factors and novel targets of non-Hodgkin lymphoma. We believe that understanding the pathophysiology of non-Hodgkin lymphoma provides a mean to improve its risk-stratification and treatment. This book is intended for medical and healthcare professionals involved in the research and clinical care of patients with non-Hodgkin lymphoma.
Hodgkin Disease -- etiology. --- Hodgkin Disease -- pathology. --- Hodgkin Disease -- therapy. --- Hodgkin's disease. --- Lymphoma, Non-Hodgkin -- etiology. --- Lymphoma, Non-Hodgkin -- pathology. --- Lymphomas --- Lymphoma --- Neoplasms by Histologic Type --- Neoplasms --- Diseases --- Lymphoma, Non-Hodgkin --- Medicine --- Health & Biological Sciences --- Oncology --- Lymphomas. --- Risk factors. --- Germinoblastomas --- Immunoblastomas --- Non-Hodgkin's lymphoma --- Reticulolymphosarcomas --- Sarcoma, Germinoblastic --- Sarcoma, Immunoblastic --- Medicine. --- Cancer research. --- Pharmacology. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Physiological effect --- Lymphoproliferative disorders --- Reticulo-endothelial system --- Tumors --- Oncology. --- Toxicology. --- Pharmacology --- Poisoning --- Poisons --- Toxicology
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Neoplastic Diseases of the Blood integrates the history, epidemiology, pathology, pathophysiology, and therapeutics of modern neoplastic hematopathology. The book is divided into five major sections, with the first four covering the spectrum of hematologic neoplasia— Chronic Leukemias and Related Disorders , Acute Leukemias, Myeloma and Related Disorders, and Lymphomas. The fifth section covers a variety of topics in supportive care. Now in its fifth edition, this classic and invaluable text brings together a team of internationally renowned experts and offers in-depth coverage of the complex interface between diagnosis and therapy. Chapters feature an accessible and easy-to-read layout and provide updates on the tremendous progress made in the last decade in the understanding of the nature of hematologic malignancies and their treatment. An authoritative and indispensable resource for students, trainees, and clinicians, this fifth edition is sure to distinguish itself as the definitive reference on this topic. .
Blood -- Diseases. --- Hematologic neoplasms. --- Hematological oncology. --- Leukemia. --- Lymphoma. --- Blood --- Hematological oncology --- Neoplasms by Histologic Type --- Paraproteinemias --- Lymphoproliferative Disorders --- Neoplasms by Site --- Hematologic Diseases --- Hemostatic Disorders --- Neoplasms, Plasma Cell --- Neoplasms --- Hemorrhagic Disorders --- Vascular Diseases --- Blood Protein Disorders --- Immunoproliferative Disorders --- Hemic and Lymphatic Diseases --- Lymphatic Diseases --- Diseases --- Immune System Diseases --- Cardiovascular Diseases --- Hematologic Neoplasms --- Lymphoma --- Multiple Myeloma --- Leukemia --- Medicine --- Health & Biological Sciences --- Pathology --- Oncology --- Multiple myeloma. --- Lymphomas. --- Germinoblastomas --- Immunoblastomas --- Non-Hodgkin's lymphoma --- Reticulolymphosarcomas --- Sarcoma, Germinoblastic --- Sarcoma, Immunoblastic --- Kahler's disease --- Plasma cell myeloma --- Leucaemia --- Leucemia --- Leucocythaemia --- Leucocythemia --- Leucosis --- Leukaemia --- Leukosis --- Medicine. --- Internal medicine. --- Hematology. --- Oncology. --- Medicine & Public Health. --- Internal Medicine. --- Lymphoproliferative disorders --- Reticulo-endothelial system --- B cells --- Monoclonal gammopathies --- Plasmacytoma --- Anemia --- Cancer --- Leucocytosis --- Preleukemia --- Tumors --- Oncology . --- Medicine, Internal --- Haematology --- Internal medicine
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