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Dans les années 1980, le traitement des lymphomes reposait sur la chimiothérapie de type CHOP pour les lymphomes non hodgkiniens (LNH) et de type MOPP pour les lymphomes de hodgkin (LH). La première ne permettait pas plus de 30 % de guérison pour les LNH et si la seconde thérapie s'accompagnait de 60 à 70 % de guérison pour les LH, elle entraînait des risques d'infertilité et de second cancer avec au premier plan le risque de leucémies aiguës myéloïdes.Les thérapeutiques ont considérablement évolué depuis cette époque. Dans les lymphomes non hodgkiniens, la distinction entre les lymphomes B et

Lymphomas. --- Germinoblastomas --- Immunoblastomas --- Lymphoma --- Non-Hodgkin's lymphoma --- Reticulolymphosarcomas --- Sarcoma, Germinoblastic --- Sarcoma, Immunoblastic --- Lymphoproliferative disorders --- Reticulo-endothelial system --- Tumors

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The mature T and NK cell lymphomas are rare, comprising approximately 10% of all malignant lymphomas. The incidence of T-cell lymphoma is variable around the world, with a higher incidence compared to B-cell lymphomas in the Asian basin. While the overall incidence of B-cell lymphomas has begun to decline in the United States, the incidence of T-cell lymphomas continues to rise. Over the last decade, a number of novel agents have been developed which target T-cell lymphomas and studies have identified novel genes and pathways associated with lymphomagenesis in T-cells.   This comprehensive volume examines the clinical and biological aspects of the T-cell lymphoproliferative disorders in adults and children. The book includes an overview of both the cutaneous and the systemic T-cell malignancies and addresses the classification of T-cell lymphomas, the clinical features of each subtype, and the relevant molecular and genetic studies. Clinical outcomes and treatment strategies are discussed with an emphasis on the development of novel biological and targeted therapies. An outstanding resource for hematologists and oncologists, this book gathers insights from experts in the field and provides the most up-to-date information on all of the T-cell lymphoma subgroups and current and emerging therapies.

Lymphomas. --- Neoplasms. --- T cells. --- Lymphomas --- Lymphoma, Non-Hodgkin --- Lymphoma --- Lymphoproliferative Disorders --- Neoplasms by Histologic Type --- Neoplasms --- Lymphatic Diseases --- Immunoproliferative Disorders --- Diseases --- Hemic and Lymphatic Diseases --- Immune System Diseases --- Lymphoma, T-Cell --- Medicine --- Health & Biological Sciences --- Oncology --- Pathology --- T lymphocytes --- Thymus-dependent cells --- Thymus-dependent lymphocytes --- Thymus-derived cells --- Germinoblastomas --- Immunoblastomas --- Non-Hodgkin's lymphoma --- Reticulolymphosarcomas --- Sarcoma, Germinoblastic --- Sarcoma, Immunoblastic --- Medicine. --- Angiology. --- Hematology. --- Oncology. --- Medicine & Public Health. --- Lymphocytes --- Lymphoproliferative disorders --- Reticulo-endothelial system --- Tumors --- Oncology  . --- Angiography. --- Blood-vessels --- Diagnosis, Radioscopic --- Radiography, Medical --- Haematology --- Internal medicine --- Blood --- Radiography

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Neoplastic Diseases of the Blood integrates the history, epidemiology, pathology, pathophysiology, and therapeutics of modern neoplastic hematopathology. The book is divided into five major sections, with the first four covering the spectrum of hematologic neoplasia— Chronic Leukemias and Related Disorders , Acute Leukemias, Myeloma and Related Disorders, and Lymphomas. The fifth section covers a variety of topics in supportive care. Now in its fifth edition, this classic and invaluable text brings together a team of internationally renowned experts and offers in-depth coverage of the complex interface between diagnosis and therapy.  Chapters feature an accessible and easy-to-read layout and provide updates on the tremendous progress made in the last decade in the understanding of the nature of hematologic malignancies and their treatment. An authoritative and indispensable resource for students, trainees, and clinicians, this fifth edition is sure to distinguish itself as the definitive reference on this topic.  .

Blood -- Diseases. --- Hematologic neoplasms. --- Hematological oncology. --- Leukemia. --- Lymphoma. --- Blood --- Hematological oncology --- Neoplasms by Histologic Type --- Paraproteinemias --- Lymphoproliferative Disorders --- Neoplasms by Site --- Hematologic Diseases --- Hemostatic Disorders --- Neoplasms, Plasma Cell --- Neoplasms --- Hemorrhagic Disorders --- Vascular Diseases --- Blood Protein Disorders --- Immunoproliferative Disorders --- Hemic and Lymphatic Diseases --- Lymphatic Diseases --- Diseases --- Immune System Diseases --- Cardiovascular Diseases --- Hematologic Neoplasms --- Lymphoma --- Multiple Myeloma --- Leukemia --- Medicine --- Health & Biological Sciences --- Pathology --- Oncology --- Multiple myeloma. --- Lymphomas. --- Germinoblastomas --- Immunoblastomas --- Non-Hodgkin's lymphoma --- Reticulolymphosarcomas --- Sarcoma, Germinoblastic --- Sarcoma, Immunoblastic --- Kahler's disease --- Plasma cell myeloma --- Leucaemia --- Leucemia --- Leucocythaemia --- Leucocythemia --- Leucosis --- Leukaemia --- Leukosis --- Medicine. --- Internal medicine. --- Hematology. --- Oncology. --- Medicine & Public Health. --- Internal Medicine. --- Lymphoproliferative disorders --- Reticulo-endothelial system --- B cells --- Monoclonal gammopathies --- Plasmacytoma --- Anemia --- Cancer --- Leucocytosis --- Preleukemia --- Tumors --- Oncology  . --- Medicine, Internal --- Haematology --- Internal medicine