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Down syndrome. --- Gene therapy. --- Trisomie 21. --- Trisomiques 21. --- Thérapie génique. --- Réadaptation

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Examples from various organs and diseases illustrate the potential benefit obtained when both therapeutic approaches are combined with delivery strategies. Representing the combined effort of several leading international research and clinical experts, this book, Emerging Trends in Cell and Gene Therapy, provides a complete account on and brings into sharp focus current trends and state-of-the-art in important areas at the interface of cell- and gene-based therapies. This book addresses the current fragmented understanding regarding these two research areas and fills the vast unmet educational need and interest of both students and researchers in academia and industry.   Main features of the book: ·         Biological aspects of stem cell sources, differentiation and engineering.   ·         Application of microfluidics to study stem cell dynamics ·         Potential clinical application of stem cells and gene therapy to specific human disease. ·         Utilization of biomaterials and stem cells in regenerative medicine with particular emphasis on spinal cord repair, ligament and bone tissue engineering. ·         Biomimetic multiscale topography for cell alignment.

Cellular therapy. --- Gene therapy. --- Tissue engineering. --- Cellular therapy --- Gene therapy --- Cells --- Cell Transplantation --- Culture Techniques --- Anatomy --- Transplantation --- Clinical Laboratory Techniques --- Surgical Procedures, Operative --- Investigative Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Stem Cell Transplantation --- Stem Cells --- Tissue Engineering --- Biology --- Health & Biological Sciences --- Cytology --- Life sciences. --- Pharmaceutical technology. --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Biosciences --- Sciences, Life --- Therapy, Gene --- Cell therapy --- Therapy, Cellular --- Therapeutic use --- Biotechnology. --- Cell biology. --- Life Sciences. --- Cell Biology. --- Gene Therapy. --- Pharmaceutical Sciences/Technology. --- Technology --- Science --- Genetic engineering --- Therapeutics --- Organotherapy --- Therapeutics, Physiological --- Transplantation of organs, tissues, etc. --- Cell transplantation --- Biomedical engineering --- Regenerative medicine --- Tissue culture --- Cytology. --- Chemical engineering --- Cell biology --- Cellular biology --- Cytologists

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Sendai virus (SeV) is not just a mouse pathogen but is evolving into a cutting-edge component of biotechnology. SeV reverse genetics originating from a pure academic need to settle long-held questions in the biology and pathogenicity of nonsegmented negative strand RNA viruses (Mononegavirales) is about to bear the impressive fruit of multipurpose cytoplasmic (non-integrating) RNA vectors. This book brings together in one source the SeV biology revealed by conventional approaches and reverse genetics, the methods to construct the first-generation SeV vector and to generate safer versions, and the applications in medical settings that have left or are about to leave the laboratory bench. The applications, which already are diverse and have high medical impact, include use as vaccine vectors against AIDS and respiratory virus infections, creation of BioKnife to resect malignant tumors, induction of “footprint (transgene) free” pluripotent stem cells, and gene therapy for peripheral arterial disease. These achievements—which are just a few of many examples—were attainable only after rigorously incorporating the rich knowledge of SeV biology that has accumulated during the several decades since the discovery of the virus. Application of SeV vector is certain to expand greatly because of its extremely high performance in transgene expression and its remarkable target cell breadth.

Sendai virus. --- Genetic Structures --- Respirovirus --- Paramyxovirinae --- Genetic Phenomena --- Phenomena and Processes --- Paramyxoviridae --- Mononegavirales --- RNA Viruses --- Viruses --- Vertebrate Viruses --- Organisms --- Genetic Vectors --- Sendai virus --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- RNA viruses --- Biotechnology. --- Genetics. --- Riboviruses --- Viruses, RNA --- Hemagglutinating virus of Japan --- Influenza D virus --- Para-influenza virus type 1 --- Parainfluenza virus type 1 --- Medicine. --- Gene expression. --- Gene therapy. --- Virology. --- Biomedicine. --- Gene Therapy. --- Gene Expression. --- Chemical engineering --- Genetic engineering --- Parainfluenza viruses --- Medical virology. --- Genes --- Genetic regulation --- Therapy, Gene --- Therapeutics --- Medical microbiology --- Virology --- Virus diseases --- Expression --- Microbiology

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Biomedical engineering --- Medicine --- Génie biomédical --- Médecine --- Periodicals. --- Périodiques --- Biomedical Engineering --- Biomedical engineering. --- Medicine. --- Clinical sciences --- Medical profession --- Clinical engineering --- Medical engineering --- Engineering, Biomedical --- Clinical Engineering --- Engineering, Clinical --- biological active substances --- quality and safety of biological pharmaceutical products --- gene therapy --- challenges in administration of biomedicines --- development of biomedicines --- production of biomedicines --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Bioengineering --- Biophysics --- Engineering --- Biomedical Technology --- Health Workforce --- Biomedical Engineering. --- Biology

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Recent years have witnessed numerous advances in stem cell research that have suggested novel strategies for the treatment of the chronic and regenerative diseases that pose a growing challenge to the provision of healthcare in the 21st century.  Nevertheless, there is little doubt that related disciplines have failed to keep pace with such developments, of which the immunology of transplant rejection is perhaps the most relevant to the nascent field of regenerative medicine.  Indeed, given that after decades of research into the mechanisms of organ allograft rejection, we remain wholly dependent on immune suppression to ensure acceptance of foreign tissues, we might legitimately ask whether there is any reason why tissues differentiated from stem cells might not suffer the same fate.  This volume seeks to address this issue by drawing on the principles of alloantigen recognition to assess the validity of early convictions that embryonic stem cell-derived tissues may prove invisible to the immune system of the host and the more recent belief that induced pluripotent stem cells, derived in a fully autologous manner, will circumvent the issue of immunogenicity.  Having debunked such assumptions and established the magnitude of the immunological barriers to be overcome, this book then draws on the expertise of internationally-recognised laboratories around the world to provide a critical assessment of the likely success of applying strategies such as stem cell banking, silencing of genes that confer immunogenicity, and the induction of transplantation tolerance to overcoming the immunological barriers in the future.  Indeed, it is only through reaching a consensus in the field that enduring solutions to such an intractable problem may ultimately emerge.

Gene therapy -- Research. --- Regenerative Medicine -- methods. --- Regenerative medicine. --- Stem cells -- Transplantation. --- Tissue Therapy -- methods. --- Stem cells --- Regenerative medicine --- Cell Transplantation --- Medicine --- Immune System Processes --- Immune System Phenomena --- Health Occupations --- Transplantation --- Disciplines and Occupations --- Surgical Procedures, Operative --- Phenomena and Processes --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Regenerative Medicine --- Transplantation Immunology --- Stem Cell Transplantation --- Biology --- Health & Biological Sciences --- Cytology --- Immunological aspects --- Immunogenetics. --- Therapeutic use. --- Genetics --- Immunity --- Immunology --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Genetic aspects --- Life sciences. --- Immunology. --- Biotechnology. --- Cell biology. --- Stem cells. --- Life Sciences. --- Stem Cells. --- Cell Biology. --- Cells --- Cell biology --- Cellular biology --- Cytologists --- Chemical engineering --- Genetic engineering --- Immunobiology --- Life sciences --- Serology --- Biosciences --- Sciences, Life --- Science --- Regeneration (Biology) --- Cytology.