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Tyrosine phosphorylation is a rapid and reversible protein modification catalyzed by the yin and yang activities of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs).  A multitude of PTPs have been implicated in human disease, with a growing number of PTPs now known to play major roles in prevalent metabolic diseases including obesity and type 2 diabetes.  Recent studies into PTP function in the context of metabolism highlight the importance of understanding the specific substrates and binding partners of these enzymes, the regulation of PTP activity, and the cell/tissue specificity of PTP functions.  This volume contains chapters which highlight many aspects of PTP function in the context of metabolism.

Biochemistry. --- Endocrinology. --- Life sciences. --- Medicine. --- Protein-tyrosine kinase. --- Protein-tyrosine phosphatase -- Metabolism -- Regulation. --- Protein-tyrosine phosphatase --- Biological Science Disciplines --- Nutritional and Metabolic Diseases --- Metabolic Phenomena --- Protein Kinases --- Phosphoric Monoester Hydrolases --- Natural Science Disciplines --- Phosphotransferases (Alcohol Group Acceptor) --- Esterases --- Phenomena and Processes --- Diseases --- Disciplines and Occupations --- Hydrolases --- Phosphotransferases --- Enzymes --- Transferases --- Enzymes and Coenzymes --- Chemicals and Drugs --- Metabolic Diseases --- Protein-Tyrosine Kinases --- Metabolism --- Protein Tyrosine Phosphatases --- Physiology --- Chemistry --- Physical Sciences & Mathematics --- Biochemistry --- Regulation --- Physiological effect. --- Regulation. --- Control of metabolism --- Metabolic control --- Metabolic regulation --- Regulation of metabolism --- Phosphotyrosine phosphatase --- PTPase --- Tyrosine phosphatase --- Tyrosine phosphoprotein phosphatase --- Tyrosyl phosphoprotein phosphatase --- Proteins. --- Life Sciences. --- Protein Science. --- Biochemistry, general. --- Biomedicine general. --- Biological control systems --- Phosphoprotein phosphatases --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Internal medicine --- Hormones --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Composition --- Proteins . --- Endocrinology . --- Biomedicine, general. --- Health Workforce --- Proteids --- Biomolecules --- Polypeptides --- Proteomics