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This volume presents a review of the latest numerical techniques used to identify ligand binding and protein complexation sites. It should be noted that there are many other theoretical studies devoted to predicting the activity of specific proteins and that useful protein data can be found in numerous databases. The aim of advanced computational techniques is to identify the active sites in specific proteins and moreover to suggest a generalized mechanism by which such protein-ligand (or protein-protein) interactions can be effected. Developing such tools is not an easy task – it requires extensive expertise in the area of molecular biology as well as a firm grasp of numerical modeling methods. Thus, it is often viewed as a prime candidate for interdisciplinary research.
Ligand binding (Biochemistry) --- Protein binding. --- Binding, Protein --- Binding, Ligand (Biochemistry) --- Polyamines. --- Protein Structure, Tertiary --- Databases, Protein --- Binding Sites --- Protein Interaction Domains and Motifs --- Data Mining --- Medicine. --- Biomedicine. --- Biomedicine general. --- Biochemistry --- Allosteric proteins --- Radioligand assay --- Dye-ligand affinity chromatography --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Biomedicine, general.
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Protein engineering. --- Protein engineering --- Protein Engineering --- Proteins --- Protein Conformation --- Carrier Proteins --- Models, Molecular --- 577.122 --- Molecular Models --- Model, Molecular --- Molecular Model --- Molecular Conformation --- Molecular Structure --- Conformation, Protein --- Conformations, Protein --- Protein Conformations --- Protein Folding --- Binding Protein --- Binding Proteins --- Carrier Protein --- Transport Protein --- Transport Proteins --- Protein, Binding --- Protein, Carrier --- Protein, Transport --- Proteins, Binding --- Proteins, Carrier --- Proteins, Transport --- Protein Binding --- Receptors, Transferrin --- 577.122 Protein metabolism --- Protein metabolism --- Engineering, Protein --- Protein design --- Biochemical engineering --- Genetic engineering --- Genetic Engineering, Protein --- Proteins, Genetic Engineering --- Genetic Engineering of Proteins --- Engineering, Protein Genetic --- Protein Genetic Engineering --- Genetic Engineering --- Directed Molecular Evolution --- DNA Shuffling --- Molecular Farming --- chemistry --- Design
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