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The recent advances in Programming Somatic Cell (PSC) including induced Pluripotent Stem Cells (iPS) and Induced Neuronal phenotypes (iN), has changed the experimental landscape and opened new possibilities. The advances in PSC have provided an important tool for the study of human neuronal function as well as neurodegenerative and neurodevelopmental diseases in live human neurons in a controlled environment. For example, reprogramming cells from patients with neurological diseases allows the study of molecular pathways particular to specific subtypes of neurons such as dopaminergic neurons in Parkinson’s Disease, Motor neurons for Amyolateral Sclerosis or myelin for Multiple Sclerosis. In addition, because PSC technology allows for the study of human neurons during development, disease-specific pathways can be investigated prior to and during disease onset. Detecting disease-specific molecular signatures in live human brain cells, opens possibilities for early intervention therapies and new diagnostic tools. Importantly, it is now feasible to obtain gene expression profiles from neurons that capture the genetic uniqueness of each patient. Importantly, once the neurological neural phenotype is detected in vitro, the so-called “disease-in-a-dish” approach allows for the screening of drugs that can ameliorate the disease-specific phenotype. New therapeutic drugs could either act on generalized pathways in all patients or be patient-specific and used in a personalized medicine approach. However, there are a number of pressing issues that need to be addressed and resolved before PSC technology can be extensively used for clinically relevant modeling of neurological diseases.
Medicine --- Health & Biological Sciences --- Neurology --- Stem cells. --- Neurons. --- Nerve cells --- Neurocytes --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Medicine. --- Neurosciences. --- Neurology. --- Biomedicine. --- Stem Cells. --- Cells --- Nervous system --- Neuropsychiatry --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Diseases --- Neurology .
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Stochastic biomathematical models are becoming increasingly important as new light is shed on the role of noise in living systems. In certain biological systems, stochastic effects may even enhance a signal, thus providing a biological motivation for the noise observed in living systems. Recent advances in stochastic analysis and increasing computing power facilitate the analysis of more biophysically realistic models, and this book provides researchers in computational neuroscience and stochastic systems with an overview of recent developments. Key concepts are developed in chapters written by experts in their respective fields. Topics include: one-dimensional homogeneous diffusions and their boundary behavior, large deviation theory and its application in stochastic neurobiological models, a review of mathematical methods for stochastic neuronal integrate-and-fire models, stochastic partial differential equation models in neurobiology, and stochastic modeling of spreading cortical depression.
Neurons --- Stochastic models --- Computational neuroscience --- Mathematical Concepts --- Statistics as Topic --- Cells --- Nervous System --- Models, Biological --- Models, Theoretical --- Epidemiologic Methods --- Anatomy --- Phenomena and Processes --- Health Care Evaluation Mechanisms --- Investigative Techniques --- Public Health --- Quality of Health Care --- Environment and Public Health --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Health Care Quality, Access, and Evaluation --- Health Care --- Models, Neurological --- Stochastic Processes --- Mathematics --- Human Anatomy & Physiology --- Health & Biological Sciences --- Physical Sciences & Mathematics --- Neuroscience --- Mathematical Statistics --- Mathematical models --- Stochastic models. --- Computational neuroscience. --- Mathematical models. --- Computational neurosciences --- Nerve cells --- Neurocytes --- Models, Stochastic --- Mathematics. --- Neurobiology. --- Probabilities. --- Statistics. --- Probability Theory and Stochastic Processes. --- Mathematical Modeling and Industrial Mathematics. --- Statistics for Life Sciences, Medicine, Health Sciences. --- Statistical analysis --- Statistical data --- Statistical methods --- Statistical science --- Econometrics --- Probability --- Statistical inference --- Combinations --- Chance --- Least squares --- Mathematical statistics --- Risk --- Models, Mathematical --- Simulation methods --- Neurosciences --- Math --- Science --- Computational biology --- Nervous system --- Distribution (Probability theory. --- Distribution functions --- Frequency distribution --- Characteristic functions --- Probabilities --- Statistics .
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