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The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition “Th17 Cells: Role in Inflammation and Autoimmune Disease” in 2008. The present volume has been completely revised with the addition of new chapters on the IL-17 receptor family and signaling, and an in-depth review of IL-22 and innate lymphoid cells. The differentiation of naïve T cells into regulatory T cells and Th17 cells as well as the plasticity of Th17 cells is discussed. The role of IL-22 in cutaneous inflammation including psoriasis has been reviewed. In addition, the volume contains critical updates on autoimmunity, organ transplantation, tumor immunology and genetic mouse models for mechanistic studies. Lastly, the latest clinical progress in neutralizing antibodies to IL-17A, IL-17RA not only confirms the therapeutic promise foreseen in 2008, but also improves our knowledge of the pathogenesis of autoimmune diseases. In summary, this is a timely update and important review of the clinical and experimental aspects of IL-17, IL-22 and their producing cells.

Inflammation. --- Pharmacology. --- Interleukins --- Cytokines --- Pathologic Processes --- Biological Science Disciplines --- Adaptive Immunity --- Intercellular Signaling Peptides and Proteins --- Natural Science Disciplines --- Pathological Conditions, Signs and Symptoms --- Immunity --- Disciplines and Occupations --- Biological Factors --- Diseases --- Immune System Phenomena --- Peptides --- Proteins --- Phenomena and Processes --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Interleukin-17 --- Inflammation --- Physiology --- Immunity, Cellular --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Interleukins. --- Medicine. --- Cancer research. --- Immunology. --- Infectious diseases. --- Proteins. --- Cytokines. --- Growth factors. --- Cell biology. --- Biomedicine. --- Cytokines and Growth Factors. --- Receptors. --- Cell Biology. --- Infectious Diseases. --- Cancer Research. --- Growth factors --- Lymphocytes --- Cell receptors. --- Cytology. --- Emerging infectious diseases. --- Oncology. --- Tumors --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Binding sites (Biochemistry) --- Cell membranes --- Cellular immunity --- Immune response --- Immunobiology --- Life sciences --- Serology --- Regulation --- Proteins . --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Cell growth factors --- Cellular growth factors --- Growth peptides --- Growth promoting substances --- Growth substances --- Peptide growth factors --- Peptide regulatory factors --- Polypeptide growth factors --- Cancer research