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Rna-binding proteins.

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GTP-binding proteins --- Interferons --- Gene expression regulation --- Virus diseases --- genetics --- immunology

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The insulin-like growth factor system has been shown to play a critical role in cancer development and progression. Insulin-like Growth Factors and Cancer: From Basic Biology to Therapeutics, specifically brings these aspects to the reader. The volume covers the epidemiological aspects of the relationships between circulating insulin and IGF-1 levels and the risk for cancer and cancer-related mortality and in particularly in disease states such as obesity and Type 2 diabetes. It then addresses the basic biology of the system and how the ligands, receptors and IGF-binding proteins affect cancer cell biology and cancer progression. Finally, it discusses the therapeutic potential of inhibiting the receptors using various newly discovered monoclonal antibodies and tyrosine kinase inhibitors that are in preclinical and clinical trials.

Cancer -- Endocrine aspects. --- Somatomedin. --- Tumors -- Growth. --- Somatomedin --- Insulin-like growth factor-binding proteins --- Cancer --- Tumors --- Intercellular Signaling Peptides and Proteins --- Carrier Proteins --- Blood Proteins --- Diseases --- Biological Factors --- Proteins --- Peptides --- Chemicals and Drugs --- Amino Acids, Peptides, and Proteins --- Somatomedins --- Neoplasms --- Insulin-Like Growth Factor Binding Proteins --- Medicine --- Human Anatomy & Physiology --- Health & Biological Sciences --- Oncology --- Animal Biochemistry --- Endocrine aspects --- Growth --- Insulin-like growth factor-binding proteins. --- Cancer. --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- IGF-binding proteins --- Somatomedin-binding proteins --- Medicine. --- Cancer research. --- Pharmacology. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Physiological effect --- Carrier proteins --- Oncology. --- Toxicology. --- Pharmacology --- Poisoning --- Poisons --- Toxicology

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 Among the many GPCRs discovered, the calcitonin family of receptors comprise of members that regulate a number of physiological processes and are involved in many pathological conditions. Therefore, understanding how these receptors function is a critical question in the field. When Foord and his colleagues discovered that a single transmembrane protein called Receptor Activity Modifying Proteins (RAMPs) could modulate the surface expression of GPCRs of the calcitonin family, it widely opened the field of receptor life cycle. Hundreds of studies have confirmed the importance of RAMPs in the life cycle of this receptor family. Receptor biology is a rapidly expanding field and with the advances in cell and molecular biology and in vivo techniques, it is very likely that the field of RAMPs will explode further and many unanswered questions will be answered with in the next few years.

Cell receptors. --- Cellular signal transduction. --- G proteins -- Receptors. --- Adaptor Proteins, Signal Transducing --- Membrane Proteins --- Proteins --- Intracellular Signaling Peptides and Proteins --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Receptor Activity-Modifying Proteins --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- G proteins --- G proteins. --- Receptors. --- GTP-binding proteins --- GTP regulatory proteins --- Guanine nucleotide-binding proteins --- Guanine nucleotide regulatory proteins --- Medicine. --- Molecular biology. --- Cell biology. --- Biomedicine. --- Biomedicine general. --- Cell Biology. --- Molecular Medicine. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Membrane proteins --- Cytology. --- Health Workforce --- Biomedicine, general.

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This volume illustrates the functional properties of NAbs. Authors from pioneering groups report in their chapters on the tissue homeostatic, tissue regenerating and regulatory properties of NAbs and NAbs in pooled human IgG. Scientists interested in the regulation and modulation of components of the immune system found a whole variety of NAbs to cytokines with regulatory and protective functions and NAbs that modulate, e.g., dendritic cells, regulatory T cells, B cells and granulocytes. Considering the large plasma pools and initial difficulties in preparing IVIG that does not induce adverse effects upon infusion into recipients, this volume ends with a historical chapter on how pooled human plasma was fractionated and the IgG component pretreated for a safe intravenous application.

Autoantibodies. --- Immunoglobulins. --- Immunoglobulins --- Serum Globulins --- Immunoproteins --- Globulins --- Blood Proteins --- Proteins --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Antibodies --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Immune globulins --- Immune serum globulin --- Medicine. --- Antibodies. --- Biomedicine. --- Biomedicine general. --- Blood proteins --- Plasma cells --- Antibody diversity --- Antigens --- Bacterial immunoglobulin-binding proteins --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Autoimmunity --- Monoclonal antibodies. --- Antibodies, Monoclonal --- Monoclonal immunoglobulins --- Molecular cloning --- Biomedicine, general. --- Health Workforce