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The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that various genetic engineering approaches will have on future candidates. Chapters in the first part of the book provide an introduction to monoclonal antibodies, their discovery and development and the fundamental technologies used in their

Monoclonal antibodies --- Immunotechnology. --- Therapeutic use. --- Antibody engineering --- Immunological engineering --- Industrial immunology --- Biotechnology --- Immunology

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Immunology. Immunopathology --- Cellular immunity. --- Molecular immunology. --- Immunity, Cellular. --- Antibody Formation --- Antigens --- Immune System Diseases --- Lymphocytes --- immunology. --- 577.27 --- Immunologie --- Immunopathologie --- Molecular bases of immunity. Molecular immunology --- 577.27 Molecular bases of immunity. Molecular immunology --- Cellular immunity --- Molecular immunology --- Immune system --- Immunity --- Immunology --- Molecular biology --- Cell-mediated immunity --- Cellular immunology --- Clonal selection theory --- Immune response --- Molecular aspects --- Immunity, Cellular --- immunology

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Tumors --- Neoplasms --- Immunotherapy. --- Immunological aspects --- therapy. --- Immunotherapies --- Tumours --- Immunological aspects. --- Pathology --- Cysts (Pathology) --- Oncology --- Tumor immunology --- Immunity, Active --- Immunologic Techniques --- Immunotherapy --- therapy --- Benign Neoplasms --- Malignancy --- Malignant Neoplasms --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Cancer --- Benign Neoplasm --- Cancers --- Malignancies --- Malignant Neoplasm --- Neoplasias --- Neoplasm, Benign --- Neoplasm, Malignant --- Neoplasms, Malignant --- Tumor --- Medical Oncology --- oncology --- immunology --- immunotherapy --- tumour immunology --- Combined Antibody Therapeutics --- Immunoteràpia --- Oncologia --- Càncer --- Immunoteràpia. --- Oncologia. --- Càncer.

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The HLA molecules are important regulators of the immune response through mediating antigen presentation and interaction between key immune mediating cells. They are also the major histocompatibilty barriers to transplantation, which is the clinical paradigm of the self versus non self concept. It is now recognized that this diverse range of gene systems involved in the control of the immune response have been shown to be important in many aspects of clinical practice. As a result many new molecular and cellular methods have been developed for identifying these genes and their polymorphisms, and immunogenetic laboratories specializing in these methods have developed to support transplantation and other clinical programs. Immunogenetics: Methods and Applications in Clinical Practice focuses on methods for human clinical practice. The emphasis rests on those assays which are of established or potential clinical utility and are likely to be included in the repertoire of tests provided by a routine diagnostic and service laboratory. This volume also contains several review chapters of the MHC complex, the KIR complex, the human immunoglobulin allotypes, as well as reviews of the methods for the detection of alloreactive NK cells and the detection of HLA antibodies by solid phase assays.  Written in the successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.   Authoritative and easily accessible, Immunogenetics: Methods and Applications in Clinical Practice seeks to serve both the immunogenetics community  and the wider scientific community with a collection of detailed information and helpful tips attained by many years of experience in the field.

Immunogenetics --- Investigative Techniques --- Immune System Phenomena --- Biology --- Publication Formats --- Transplantation Immunology --- Phenomena and Processes --- Immune System Processes --- Biological Science Disciplines --- Publication Characteristics --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Natural Science Disciplines --- Disciplines and Occupations --- Genetics --- Immunogenetic Phenomena --- Immunologic Techniques --- Histocompatibility --- Methods --- Laboratory Manuals --- Immunity --- Health & Biological Sciences --- Microbiology & Immunology --- Biophysics --- Immunogénétique --- Immunité --- Histocompatibilité --- Immunogenetic Phenomena. --- Méthodes --- Génétique --- methods --- genetics --- Disease --- Methodological Studies --- Methodological Study --- Procedures --- Studies, Methodological --- Study, Methodological --- Method --- Procedure --- Immunocompatibility --- Tissue Compatibility --- Compatibilities, Tissue --- Compatibility, Tissue --- Histocompatibilities --- Immunocompatibilities --- Tissue Compatibilities --- Immunogenetic --- Antibody Dissociation --- Immunologic Technic --- Immunologic Technics --- Immunologic Technique --- Immunological Technics --- Immunological Techniques --- Technic, Immunologic --- Technics, Immunologic --- Technique, Immunologic --- Techniques, Immunologic --- Antibody Dissociations --- Dissociation, Antibody --- Dissociations, Antibody --- Immunological Technic --- Immunological Technique --- Technic, Immunological --- Technics, Immunological --- Technique, Immunological --- Techniques, Immunological --- Allergy and Immunology --- Immunogenetic Phenomenon --- Immunogenetic Concepts --- Immunogenetic Processes --- Concept, Immunogenetic --- Concepts, Immunogenetic --- Immunogenetic Concept --- Phenomena, Immunogenetic --- Phenomenon, Immunogenetic --- Processes, Immunogenetic --- Natural Sciences --- Physical Sciences --- Discipline, Natural Science --- Disciplines, Natural Science --- Natural Science --- Natural Science Discipline --- Physical Science --- Science, Natural --- Science, Physical --- Sciences, Natural --- Sciences, Physical --- Biologic Sciences --- Biological Science --- Science, Biological --- Sciences, Biological --- Biological Sciences --- Life Sciences --- Biologic Science --- Biological Science Discipline --- Discipline, Biological Science --- Disciplines, Biological Science --- Life Science --- Science Discipline, Biological --- Science Disciplines, Biological --- Science, Biologic --- Science, Life --- Sciences, Biologic --- Sciences, Life --- Immune System Concepts --- Immune System Phenomenon --- Immune System Process --- Concept, Immune System --- Concepts, Immune System --- Immune System Concept --- Phenomena, Immune System --- Phenomenon, Immune System --- Process, Immune System --- Processes, Immune System --- Immunology, Transplantation --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Immunology --- immunology --- Immunological aspects --- Genetic aspects --- Medicine. --- Human genetics. --- Immunology. --- Biomedicine. --- Human Genetics. --- Immunobiology --- Life sciences --- Serology --- Heredity, Human --- Human biology --- Physical anthropology --- Clinical sciences --- Medical profession --- Medical sciences --- Pathology --- Physicians --- Immunologic Techniques. --- methods. --- genetics. --- Méthodes. --- Génétique.

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Most human pathogens utilize mucosal surfaces to access the host. This volume is focused on the development of vaccines which generate immune effectors capable of blocking mucosal entry or peripheral pathogen spread. A critical first step in the design of mucosal vaccines is the selection of administration route. Not all mucosal immunization routes are created equally when it comes to eliciting immune responses in multiple body compartments. This subject and situations when a mucosal route may not be required for vaccine delivery are reviewed here with an emphasis on the sublingual immunization route, which may offer a safer alternative to the nasal route for induction of broadly disseminated immune responses. External host defenses that inhibit entry of microorganisms at mucosal surfaces also pose obstacles to the efficient internalization of mucosally-applied vaccines. Transcutaneous immunization with appropriate adjuvants and permeation enhancers can induce mucosal immune responses and may be advantageous for bypassing these luminal barriers. Other chapters describe strategies for enhancing uptake of mucosal vaccines, for instance through targeted delivery to antigen-sampling M cells, construction of virus-like particles which mimic natural pathogens, addition of mucoadhesives or formulation as nanoparticles. Topics include edible vaccines as well as plant-based production of subunit or particulate vaccines that could be administered by any route. Dry powder vaccines that could be insufflated or directly applied to mucosal surfaces may be particularly ideal for mass vaccination in developing countries. The manufacture, stability and efficacy of powder formulations is comprehensively reviewed. We conclude with chapters on two of the greatest challenges facing mucosal vaccine development: human immunodeficiency virus and bioterrorist agents. This monograph highlights progress and information that should prove invaluable for the development of contemporary vaccines that prevent infection by these and other mucosal pathogens.

Vaccines. --- Mucous membrane --- Vaccines --- Vaccination --- Biological Products --- Immunity --- Membranes --- Immune System Phenomena --- Tissues --- Complex Mixtures --- Phenomena and Processes --- Anatomy --- Chemicals and Drugs --- Immunity, Mucosal --- Mucous Membrane --- Health & Biological Sciences --- Biology --- Pharmacy, Therapeutics, & Pharmacology --- Microbiology & Immunology --- Immunology --- Immunology. --- Mucosa --- Mucosal tissue --- Tunica mucosa --- Medicine. --- Antibodies. --- Biomedicine. --- Vaccine. --- Biologicals --- Antibodies --- Immune globulins --- Immune serum globulin --- Blood proteins --- Globulins --- Plasma cells --- Antibody diversity --- Antigens --- Bacterial immunoglobulin-binding proteins --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Medical sciences --- Pathology --- Physicians --- Epithelium --- Membranes (Biology) --- Monoclonal antibodies. --- Antibodies, Monoclonal --- Monoclonal immunoglobulins --- Immunoglobulins --- Molecular cloning