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Lymphomas. --- Skin --- Germinoblastomas --- Immunoblastomas --- Lymphoma --- Non-Hodgkin's lymphoma --- Reticulolymphosarcomas --- Sarcoma, Germinoblastic --- Sarcoma, Immunoblastic --- Lymphoproliferative disorders --- Reticulo-endothelial system --- Tumors. --- Tumors

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Macrophages are tissue resident phagocytes that have important roles in development and immunity. The observation that cancers become infiltrated by large numbers of macrophages was first made by Virchow in 1863, clinical and experimental studies suggest tumor-associated macrophages (TAM) are critical to promote carcinogenesis and tumor-progression, however to this day it still isn’t clear what regulates the recruitment of macrophages in tumors and what drives their pro-tumor functions. This volume will provide an overview of current research on the form and function of TAM, highlighting both the mechanistic roles they play in carcinogenesis and tumor progression as well as the molecular mechanisms that control their phenotype and function, and the final chapter addresses the issue of TAM as a potential target in cancer therapy.

Cancer -- Research. --- Macrophages. --- Tumors. --- Macrophages --- Tumors --- Immunology --- Cancer --- Disease Attributes --- Mononuclear Phagocyte System --- Phagocytes --- Connective Tissue Cells --- Myeloid Cells --- Diseases --- Cells --- Immune System --- Pathologic Processes --- Anatomy --- Pathological Conditions, Signs and Symptoms --- Hemic and Immune Systems --- Neoplasms --- Disease Progression --- Biology --- Medicine --- Health & Biological Sciences --- Oncology --- Microbiology & Immunology --- Growth --- Immunological aspects --- Tumours --- Histiocytes --- Mononuclear phagocytes --- Medicine. --- Cancer research. --- Pharmacology. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- Pathology --- Cysts (Pathology) --- Antigen presenting cells --- Connective tissue cells --- Killer cells --- Reticulo-endothelial system

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Granulocyte colony-stimulating factor (G-CSF or GCSF) is a secreted glycoprotein that stimulates the proliferation and differentiation of granulocyte precursor cells, and induces mobilization of peripheral blood progenitor cells from the bone marrow. Development of recombinant human G-CSF has had a profound impact on the treatment of many diseases, including severe chronic neutropenia and cancer, and has enabled peripheral stem cell transplantation to supplant bone marrow transplantation in the autologous setting. This Milestones in Drug Therapy volume describes the experience of the last 20 years of treatment with recombinant human G-CSF, including the basic science, the use of recombinant human G-CSF in both the oncology and nononcology settings, and the safety and economics of its use. Many of the authors were the original investigators of recombinant human G-CSF and other authors are key researchers who provide their outlook for the next 20 years for use of and research with recombinant human G-CSF.

Drug abuse -- Etiology -- Handbooks, manuals, etc. --- Drug abuse -- Psychological aspects -- Handbooks, manuals, etc. --- Filgrastim --- Colony-Stimulating Factors --- Leukemia --- Neoplasms, Plasma Cell --- Receptors, Colony-Stimulating Factor --- Lymphoproliferative Disorders --- Hematologic Diseases --- Hemostatic Disorders --- Therapeutics --- Paraproteinemias --- Hemorrhagic Disorders --- Hematopoietic Cell Growth Factors --- Receptors, Cytokine --- Immunoproliferative Disorders --- Neoplasms by Histologic Type --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Receptors, Growth Factor --- Hemic and Lymphatic Diseases --- Blood Protein Disorders --- Glycoproteins --- Vascular Diseases --- Cytokines --- Proteins --- Receptors, Peptide --- Neoplasms --- Receptors, Immunologic --- Diseases --- Immune System Diseases --- Cardiovascular Diseases --- Receptors, Cell Surface --- Amino Acids, Peptides, and Proteins --- Intercellular Signaling Peptides and Proteins --- Membrane Proteins --- Chemicals and Drugs --- Biological Factors --- Peptides --- Multiple Myeloma --- Granulocyte Colony-Stimulating Factor --- Drug Therapy --- Leukocyte Disorders --- Leukemia, Myeloid --- Receptors, Granulocyte Colony-Stimulating Factor --- Health & Biological Sciences --- Biology --- Pharmacy, Therapeutics, & Pharmacology --- Microbiology & Immunology --- Granulocyte-macrophage colony-stimulating factor. --- Colony-stimulating factors (Physiology) --- Granulocytes. --- Macrophages. --- Histiocytes --- Mononuclear phagocytes --- Granular leucocytes --- CSF-GM (Colony-stimulating factor) --- GM-CSF (Colony-stimulating factor) --- Histamine-producing cell-stimulating factor --- Medicine. --- Cancer research. --- Immunology. --- Pharmacology. --- Hematology. --- Cytokines. --- Growth factors. --- Biomedicine. --- Pharmacology/Toxicology. --- Cancer Research. --- Cytokines and Growth Factors. --- Antigen presenting cells --- Connective tissue cells --- Killer cells --- Phagocytes --- Reticulo-endothelial system --- Leucocytes --- Hematopoietic growth factors --- Toxicology. --- Oncology. --- Haematology --- Internal medicine --- Blood --- Cellular immunity --- Immune response --- Immunobiology --- Life sciences --- Serology --- Tumors --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Regulation --- Toxicology --- Cell growth factors --- Cellular growth factors --- Growth peptides --- Growth promoting substances --- Growth substances --- Peptide growth factors --- Peptide regulatory factors --- Polypeptide growth factors --- Cancer research --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect