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“Lactoferrin and its Role in Wound Healing” summarizes the recent advances of molecular mechanisms of wound healing. It is a complex physiological process that requires the regulation of different types of cells such as immune cells, keratinocytes, fibroblasts, and endothelial cells. Lactoferrin was first identified as an iron-binding glycoprotein abundantly found in milk. It has been considered to play important roles in host defense, since lactoferrin shows broad spectrum of anti-bacterial and anti-viral activities, arising from its iron-chelating property. Furthermore, lactoferrin can regulate the function of innate and adaptive immune cells and exhibits immuno-modulating properties. These activities of lactoferrin implicate that potential use of lactoferrin as a wound healing agent. In addition, this book shows that lactoferrin is a potent regulator of dermal fibroblasts and epidermal keratinocytes, and promotes skin or corneal epithelial wound healing by increasing their proliferation, migration or deposition of extracellular matrix (ECM) components such as collagen and hyaluronan. This book provides the scientific background on use of lactoferrin as a wound healing agent. Indeed, lactoferrin exerts its biological effects by binding to specific lactoferrin receptors on target cells. This book also covers the in-depth information on roles of lactoferrin as a signaling molecule.

Lactoferrin -- Therapeutic use. --- Wound healing. --- Wound healing --- Lactoferrin --- Lactoglobulins --- Iron-Binding Proteins --- Glycoproteins --- Regeneration --- Biological Science Disciplines --- Proteins --- Natural Science Disciplines --- Biological Processes --- Carrier Proteins --- Metalloproteins --- Globulins --- Milk Proteins --- Amino Acids, Peptides, and Proteins --- Dietary Proteins --- Biological Phenomena --- Disciplines and Occupations --- Phenomena and Processes --- Chemicals and Drugs --- Physiology --- Wound Healing --- Human Anatomy & Physiology --- Surgery & Anesthesiology --- Health & Biological Sciences --- Animal Biochemistry --- Wounds & Injuries --- Therapeutic use --- Lactoferrin. --- Healing of wounds --- Wound repair --- Lactoferrins --- Medicine. --- Human physiology. --- Proteins. --- Cell biology. --- Cell membranes. --- Biomedicine. --- Biomedicine general. --- Human Physiology. --- Cell Biology. --- Protein Science. --- Receptors. --- Membrane Biology. --- Carrier proteins --- Iron proteins --- Milk proteins --- Healing --- Regeneration (Biology) --- Cytology. --- Biochemistry. --- Cell receptors. --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Membranes (Biology) --- Glycocalyces --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Binding sites (Biochemistry) --- Cell membranes --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Human biology --- Human body --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians --- Composition --- Biomedicine, general. --- Health Workforce --- Proteins . --- Cell membranes . --- Proteids --- Biomolecules --- Polypeptides --- Proteomics