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This medical dissertation by Tove Sivik investigates the role of 17β dehydrogenase type 14 (17βHSD14) in both normal physiology and breast cancer. The study highlights the enzyme's significance in regulating sex hormone levels, particularly in post-menopausal women, and its potential as a predictive marker for breast cancer treatment with tamoxifen. The research analyzes the enzyme's expression patterns in human tissues and its impact on estradiol and testosterone metabolism. The findings suggest that high levels of 17βHSD14 correlate with better clinical outcomes in breast cancer, emphasizing the enzyme's relevance in estrogen regulation. The work targets researchers and clinicians interested in cancer treatment and hormonal regulation.

Estrogen --- Hormone therapy. --- Physiological effect.

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A growing majority of women in the western hemisphere have been delaying initiation of childbearing to later in life. Consequently, more women in their late 30s to early 40s are attempting to get pregnant for the first time than ever before. Since the incidence of most cancers increases with age, delayed childbearing results in more female cancer survivors interested in fertility preservation. In this book, the editors provide strategies for fertility preservation in women and men who require gonadotoxic treatment. In addition, epidemiologic, ethical, medico-legal, psychologic, and social aspects of fertility preservation are discussed. Using a format that combines concise scientific background with practical methodological information and easy-to-grasp algorithms, the chapters all conform to a uniform structure, including a brief abstract, keyword glossary, step by step protocol of laboratory procedures, key issues in commentary and a list of references. The result is a unique, practical reference guide for reproductive endocrinologists, urologists, embryologists, reproductive scientists, and oncologists.

Infertility -- Diagnosis. --- Infertility -- Hormone therapy. --- Reproductive Techniques, Assisted. --- Infertility --- Reproductive health --- Human reproduction --- Persons --- Named Groups --- Men --- Women --- Medicine --- Health & Biological Sciences --- Urology & Nephrology --- Clinical Endocrinology --- Gynecology & Obstetrics --- Prevention --- Fertility, Human. --- Cancer --- Endocrine aspects. --- Cancer endocrinology --- Hormonal aspects of cancer --- Human fertility --- Natality --- Hormonal aspects --- Medicine. --- Obstetrics. --- Endocrinology. --- Urology. --- Cell biology. --- Developmental biology. --- Medicine & Public Health. --- Developmental Biology. --- Cell Biology. --- Obstetrics/Perinatology. --- Demography --- Cytology. --- Obstetrics/Perinatology/Midwifery. --- Maternal-fetal medicine --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Development (Biology) --- Growth --- Ontogeny --- Genitourinary organs --- Internal medicine --- Hormones --- Diseases --- Endocrinology .