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The Frozen Section Library series provides concise, user-friendly, site specific handbooks that are well illustrated and highlight the pitfalls, artifacts and differential diagnosis issues that arise in the hurried frozen section scenario. Frozen Section Library: Breast provides an easy reference and pocket book about the nuances of adequately handling breast specimens in a fashion that meets the increasingly complex environment of breast pathology. The pros and cons of frozen section versus use of touch imprint as well as related quality assurance requirements are addressed. Other less common uses of intraoperative evaluation, such as diagnosis and margin evaluation are described. The volume includes recommended guidelines for evaluation and documentation of specific gross pathologic features, in conjunction with radiological imaging. Techniques and protocols for such examinations are illustrated. The volume closes with an overview of the newly published guidelines for handling a variety of breast specimens, which are intended to be used for assessment of predictive factors. Syed K. Mohsin, M.D. is the Head of Breast Pathology and Medical Director, Immunohistochemistry, Riverside Methodist Hospital, Columbus, OH.

Breast -- Diseases -- Atlases. --- Frozen tissue sections -- Atlases. --- Breast --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Publication Formats --- Cryoultramicrotomy --- Medicine --- Breast Diseases --- Neoplasms by Site --- Body Regions --- Health Occupations --- Anatomy --- Neoplasms --- Skin Diseases --- Microtomy --- Publication Characteristics --- Histocytological Preparation Techniques --- Disciplines and Occupations --- Skin and Connective Tissue Diseases --- Diseases --- Histological Techniques --- Cytological Techniques --- Clinical Laboratory Techniques --- Investigative Techniques --- Breast Neoplasms --- Diagnosis --- Frozen Sections --- Pathology --- Atlases --- Health & Biological Sciences --- Gynecology & Obstetrics --- Oncology --- Cancer --- Diseases. --- Medicine. --- Pathology. --- Medicine & Public Health. --- Disease (Pathology) --- Medical sciences --- Medicine, Preventive

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Airway sensory nerve terminals are tailored to detect changes in the physical and chemical environment, thereby supplying local pulmonary information to the central nervous system. Since most intrapulmonary nerve terminals arise from fibres travelling in the vagal nerve, the classification of ‘sensory airway receptors’ is largely based on their action potential characteristics, electrophysiologically registered from the vagal nerve. However, the architecture of airways and lungs makes it nearly impossible to functionally locate the exact nerve terminals that are responsible for the transduction of a particular intrapulmonary stimulus. In this monograph we focus on three sensory receptor end organs in lungs that are currently morphologically well-characterised: smooth muscle-associated airway receptors (SMARs), neuroepithelial bodies (NEBs) and visceral pleura receptors (VPRs). Unravelling the main functional morphological and neurochemical characteristics of these sensory receptors using advanced immunohistochemistry and confocal microscopy has already allowed us to draw important conclusions about their potential function(s). The current development of ex vivo lung models for the selective identification of SMARs, NEBs and VPRs using vital staining will certainly facilitate direct physiological studies of these morphologically well-characterised airway receptors, since these models allow direct live studies of their functional properties.

Airway (Medicine). --- Lungs -- Innervation. --- Sensory receptors. --- Sensory receptors --- Lungs --- Airway (Medicine) --- Histocytochemistry --- Muscles --- Immunochemistry --- Respiratory System --- Neurons, Afferent --- Immunologic Tests --- Biological Science Disciplines --- Peripheral Nervous System --- Cytological Techniques --- Biochemistry --- Histological Techniques --- Neurons --- Anatomy --- Laboratory Techniques and Procedures --- Immunologic Techniques --- Tissues --- Natural Science Disciplines --- Nervous System --- Histology --- Musculoskeletal System --- Cells --- Disciplines and Occupations --- Diagnosis --- Investigative Techniques --- Chemistry --- Clinical Laboratory Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Immunohistochemistry --- Muscle, Smooth --- Sensory Receptor Cells --- Lung --- Physiology --- Human Anatomy & Physiology --- Medicine --- Health & Biological Sciences --- Respiratory System Diseases --- Innervation --- Cardiopulmonary system. --- Cardiopulmonary system --- Neurochemistry. --- Physiology. --- Cardiopneumatic system --- Cardiorespiratory system --- Pneumocardial system --- Medicine. --- Human physiology. --- Biomedicine. --- Human Physiology. --- Neurosciences --- Organs (Anatomy) --- Human biology --- Medical sciences --- Human body

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This atlas will illustrate the distribution and morphological features of interstitial cells of Cajal (ICC) which are the key cells to understanding of the regulatory mechanism of gastrointestinal motility, since ICC act as both pacemaker and as intermediates in neural transmission, and since ICC show specific distribution patterns depending on their anatomical positions. All subtypes of ICC located in the different tissue layers and different levels of the gastrointestinal tract will be revealed by immunohistochemistry for Kit receptors and nerves by using mainly whole-mount stretch preparation of the guinea-pig tissues. Three-dimensional reconstruction of confocal images will particularly help the readers to understand the peculiar arrangement of ICC networks in situ and the correlation between ICC and nerves. Electron micrographs will help illustrate the characteristic features of ICC and their ultrastructural differences from fibroblasts, smooth muscles and other interstitial cells.

Biomedicine. --- Gastrointestinal system -- Cytology -- Atlases. --- Medicine. --- Histocytochemistry --- Muscle Cells --- Microscopy --- Immunologic Tests --- Immunochemistry --- Biochemistry --- Laboratory Techniques and Procedures --- Diagnostic Imaging --- Cytological Techniques --- Investigative Techniques --- Histological Techniques --- Immunologic Techniques --- Cells --- Histology --- Clinical Laboratory Techniques --- Diagnosis --- Anatomy --- Diagnostic Techniques and Procedures --- Biological Science Disciplines --- Chemistry --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Natural Science Disciplines --- Disciplines and Occupations --- Immunohistochemistry --- Interstitial Cells of Cajal --- Microscopy, Confocal --- Biology --- Medicine --- Health & Biological Sciences --- Cytology --- Urology & Nephrology --- Interstitial cystitis. --- Gastrointestinal system --- Diseases. --- Bladder pain syndrome --- BPS (Bladder pain syndrome) --- Hunner's ulcer --- IC (Interstitial cystitis) --- IC/PBS (Interstitial cystitis) --- Painful bladder syndrome --- PBS (Painful bladder syndrome) --- Biomedicine general. --- Cystitis --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Biomedicine, general.