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 Among the many GPCRs discovered, the calcitonin family of receptors comprise of members that regulate a number of physiological processes and are involved in many pathological conditions. Therefore, understanding how these receptors function is a critical question in the field. When Foord and his colleagues discovered that a single transmembrane protein called Receptor Activity Modifying Proteins (RAMPs) could modulate the surface expression of GPCRs of the calcitonin family, it widely opened the field of receptor life cycle. Hundreds of studies have confirmed the importance of RAMPs in the life cycle of this receptor family. Receptor biology is a rapidly expanding field and with the advances in cell and molecular biology and in vivo techniques, it is very likely that the field of RAMPs will explode further and many unanswered questions will be answered with in the next few years.

Cell receptors. --- Cellular signal transduction. --- G proteins -- Receptors. --- Adaptor Proteins, Signal Transducing --- Membrane Proteins --- Proteins --- Intracellular Signaling Peptides and Proteins --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Receptor Activity-Modifying Proteins --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- G proteins --- G proteins. --- Receptors. --- GTP-binding proteins --- GTP regulatory proteins --- Guanine nucleotide-binding proteins --- Guanine nucleotide regulatory proteins --- Medicine. --- Molecular biology. --- Cell biology. --- Biomedicine. --- Biomedicine general. --- Cell Biology. --- Molecular Medicine. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Membrane proteins --- Cytology. --- Health Workforce --- Biomedicine, general.

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This book provides a broad survey of various topics pertaining to G protein coupled receptor (GPCR) assembly into specific signalling complexes, and the regulation of the events leading to this assembly. Throughout this book, we focus on one main area: GPCRs are involved in highly efficient and specific activation of signalling pathways; how are these signalling complexes assembled to generate such specificity? To address this issue, we need to understand how receptors and their signalling partners are synthesized, folded correctly and assembled in order to generate functional complexes. The effects of oligomerization on specificity and efficacy of signal transduction are also discussed. Once receptor complexes are assembled, how are they targeted to different intracellular sites and what controls the trafficking of GPCR signalling complexes? Finally, defects in synthesis, maturation or trafficking can alter functionality of GPCR signalling complexes; how can we manipulate these systems to normalize them functionally?  Therefore, the topics to be covered in this book are: 1) Molecular chaperones involved in regulating (quality control) of GPCR synthesis; 2) Assembly of signalling complexes, or subunits of the complex and their organization; 3) GPCR oligomerization; 4) GPCR trafficking; 5) Problems of trafficking: pharmacological chaperones to the rescue.

Cell organelles -- Periodicals. --- Cytochemistry -- Periodicals. --- G proteins --- Cellular signal transduction --- Receptors, Cell Surface --- Cell Physiological Processes --- Natural Science Disciplines --- Biochemical Processes --- Metabolic Phenomena --- Phenomena and Processes --- Cell Physiological Phenomena --- Chemical Processes --- Membrane Proteins --- Biochemical Phenomena --- Disciplines and Occupations --- Chemical Phenomena --- Proteins --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Receptors, G-Protein-Coupled --- Signal Transduction --- Chemistry --- Metabolism --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Receptors --- Cellular signal transduction. --- Receptors. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- GTP-binding proteins --- GTP regulatory proteins --- Guanine nucleotide-binding proteins --- Guanine nucleotide regulatory proteins --- Medicine. --- Pharmacology. --- Medical biochemistry. --- Proteins. --- Biomedicine. --- Biomedicine general. --- Pharmacology/Toxicology. --- Medical Biochemistry. --- Membrane proteins --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Toxicology. --- Cell receptors. --- Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Binding sites (Biochemistry) --- Cell membranes --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Composition --- Toxicology --- Health Workforce --- Proteins . --- Biomedicine, general. --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect --- Clinical biochemistry. --- Biomedical Research. --- Research. --- Biological research --- Biomedical research