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Circular dichroism. --- DNA-binding proteins. --- Proteins --- Dichroism
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With over 60,000 referenced publications, p53 has emerged as one of the most important factors in human cancer. Research on p53 has led to a complete overhaul of our understanding of the molecular basis of human cancer. In recent years, these major advances in knowledge are starting to impact on cancer management and therapy. This book thus captures a critical turning point in p53 research, from basic to translational research and clinical application. p53 in the Clinics follows the success of 25 Years of p53 Research and condensates in a series of authoritative chapters the considerable progress on the applications of p53 into the clinics and the substantial advances on diseases caused by inheritance of p53 defects, on somatic p53 mutations as biomarkers in molecular pathology, on progress in gene therapy and on developments of innovative drugs and clinical trials. This volume will appeal to a wide audience of students and professionals in basic and clinical cancer research and treatment, and will highlight the exciting “next steps” in p53 research and applications.
p53 antioncogene. --- p53 protein. --- Protein p53 --- Protein TP53 --- TP53 protein --- p53 gene --- p53 suppressor gene --- Medicine. --- Cancer research. --- Pharmacology. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- DNA-binding proteins --- Phosphoproteins --- Tumor suppressor proteins --- Antioncogenes
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Rapid actions of sex steroids play a critical role in mediating the biological outcome of target tissues. This book reviews the importance of these non-genomic effects in initiation and progression of breast and prostate cancers. Particular emphasis is placed on discussing how rapid steroid actions not only impact disease development and response to conventional therapies for these two types of cancers, but have also led to the identification of potential new therapeutic targets and treatment possibilities for cancer patients. The book reviews the fundamental basis of target development and the current status of these studies, which are providing valuable insights in key areas of breast and prostate cancers. Particular emphasis is placed on discussing how rapid steroid actions not only impact disease development and response to conventional therapies for these two types of cancers, but have also led to the identification of potential new therapeutic targets and treatment possibilities for cancer patients. The book reviews the fundamental basis of target development and the current status of these studies, which are providing valuable insights in key areas of breast and prostate cancers.
Breast -- Cancer -- Chemotherapy. --- Hormones, Sex -- Carcinogenicity. --- Hormones, Sex -- Receptors. --- Prostate -- Cancer -- Chemotherapy. --- Steroid hormones -- Therapeutic use. --- Hormones, Sex --- Breast --- Prostate --- Prostatic Diseases --- Gonadal Hormones --- Breast Diseases --- Genital Neoplasms, Male --- Receptors, Cytoplasmic and Nuclear --- Neoplasms by Site --- Therapeutics --- Urogenital Neoplasms --- Hormones --- Proteins --- Neoplasms --- Transcription Factors --- DNA-Binding Proteins --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Genital Diseases, Male --- Skin Diseases --- Diseases --- Male Urogenital Diseases --- Amino Acids, Peptides, and Proteins --- Skin and Connective Tissue Diseases --- Hormones, Hormone Substitutes, and Hormone Antagonists --- Chemicals and Drugs --- Breast Neoplasms --- Prostatic Neoplasms --- Drug Therapy --- Gonadal Steroid Hormones --- Receptors, Steroid --- Human Anatomy & Physiology --- Medicine --- Health & Biological Sciences --- Animal Biochemistry --- Oncology --- Physiological effect --- Cancer --- Endocrine aspects --- Hormones, Sex. --- Steroid hormones. --- Sex factors. --- Treatment. --- Hormonal steroids --- Female sex hormone --- Male sex hormone --- Sex hormones --- Sex differences --- Medicine. --- Cancer research. --- Endocrinology. --- Biomedicine. --- Cancer Research. --- Biomedicine general. --- Steroids --- Steroid hormones
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