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This book focuses on the functional significance of targeting apoptosis for the treatment of prostate cancer. New concepts on the challenges relating to the development of resistance by androgen-independent tumors are introduced, in terms of the contribution of anoikis and cross-talk of androgens with key growth factor signaling pathways. This volume also provides insightful discussion on the exploitation of the apoptotic and angiogenic synergism towards complete eradication of prostate tumors. Last but not least, it includes reflections on the drug development challenge based on the analysis

Apoptosis. --- Prostate --- Cell death --- Cancer --- Treatment.

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The content of this book gives a multi-disciplinary approach into the anti-cancer research field related to natural products and dietary compounds. Mainly, it covers the area of antitumor activity through an in-depth description of the cytotoxic, anti-inflammatory and anti-oxidant properties in cancer, inflammatory and cardio-vascular diseases. The cell death inducing mechanisms (apoptosis, anti-proliferative activity, angiogenesis, cell cycle control, cytostatic property and autophagy) give an overview of how natural products are able to target cancer cells.

Cancer -- Treatment. --- Cancer. --- Critical care medicine. --- Cell Physiological Processes --- Complex Mixtures --- Cell Physiological Phenomena --- Chemicals and Drugs --- Phenomena and Processes --- Cell Death --- Biological Products --- Cell death. --- Organic compounds. --- Compounds, Organic --- Organic chemicals --- Cell degeneration --- Medicine. --- Biomedicine. --- Biomedicine general. --- Carbon compounds --- Cells --- Death (Biology) --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Biomedicine, general.

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The Endoplasmic Reticulum (ER) is an organelle with extraordinary signaling and homeostatic functions. It is the organelle responsible for protein folding, maturation, quality control and trafficking of proteins destined for the plasma membrane or for secretion into the extracellular environment. Failure, overloading or malfunctioning of any of the signaling or quality control mechanisms occurring in the ER may provoke a stress condition known as ‘ER stress’. Accumulating evidence indicates that ER stress may dramatically perturb interactions between the cell and its environment, and contribute to the development of human diseases, ranging from metabolic diseases and cancer to neurodegenerative diseases, or impact therapeutic outcome.  This book primarily focuses on the pathophysiology of ER stress.  It introduces the molecular bases of ER stress, the emerging relevance of the ER-mitochondria cross-talk, the signaling pathways engaged and cellular responses to ER stress, including the adaptive Unfolded Protein Response (UPR), autophagy as well as cell death. Next the book addresses the role of ER stress in physiology and in the etiology of relevant pathological conditions, like carcinogenesis and inflammation, neurodegeneration and  metabolic disease. The last chapter describes how ER stress pathways can be targeted for therapeutic benefit.  Altogether, this book will provide the reader with an exhaustive view of ER stress biology and the latest insights in the role of ER stress in relevant human diseases.

Endoplasmic reticulum. --- Proteins -- Metabolism. --- Proteins -- Physiological transport. --- Biology --- Health & Biological Sciences --- Cytology --- Medicine. --- Immunology. --- Molecular biology. --- Cell biology. --- Cell physiology. --- Apoptosis. --- Biomedicine. --- Biomedicine general. --- Molecular Medicine. --- Cell Biology. --- Cell Physiology. --- Cell organelles --- Cytology. --- Immunobiology --- Life sciences --- Serology --- Cell function --- Physiology --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Clinical sciences --- Medical profession --- Human biology --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Biomedicine, general. --- Cell death --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology

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This volume includes contributions by the leading experts in the field of yeast aging. Budding yeast (Saccharomyces cerevisiae) and other fungal organisms provide models for aging research that are relevant to organismic aging and to the aging processes occurring in the human body. Replicative aging, in which only the mother cell ages while the daughter cell resets the clock to zero is a model for the aging of stem cell populations in humans, while chronological aging (measured by survival in stationary phase) is a model for the aging processes in postmitotic cells (for instance, neurons of the brain). Most mechanisms of aging are studied in yeast. Among them, this book discusses: mitochondrial theories of aging, emphasizing oxidative stress and retrograde responses; the role of autophagy and mitophagy; the relationship of apoptosis to aging processes; the role of asymmetric segregation of damage in replicative aging; the role of replication stress; and the role of the cytoskeleton in aging. Modern methods of yeast genetics and genomics are described that can be used to search for aging-specific functions in a genome-wide unbiased fashion. The similarities in the pathology of senescence (studied in yeast) and of cancer cells, including genome instability, are examined.

apoptose --- microbiologie --- histologie --- General microbiology --- vrije radicalen --- Immunology. Immunopathology --- geriatrie --- enzymen --- Geriatrics --- Human histology. Human cytology --- gisten --- biologie --- immunochemie --- cytologie --- anti-oxidantia --- Yeast. --- Yeast --- Aging --- Aging. --- Molecular aspects. --- Life sciences. --- Geriatrics. --- Cytology. --- Microbiology. --- Life Sciences, general. --- Geriatrics/Gerontology. --- Cell Biology. --- Apoptosis. --- Oxidative Stress. --- Medicine --- Gerontology --- Older people --- Biosciences --- Sciences, Life --- Science --- Microbial biology --- Biology --- Microorganisms --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Diseases --- Health and hygiene --- Cell biology. --- Oxidative stress. --- Oxidation-reduction reaction --- Stress (Physiology) --- Cell death

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In the last decade, there has been a remarkable explosion of knowledge in hematologic cancer from basic molecular biology and pathology to clinical therapy. This has led to many new advance and insights in the understanding of pathobiology of malignant hematology. New knowledge of disease molecular pathology, cytogenetic, epigenetic and genomic alterations have provided new strategies to attack and eradicate tumor cells at molecular level and significantly impacted our current therapeutics for hematological malignancies. The recent and ongoing rapid expansion of knowledge in this area has become extensive, dynamic and diffuse over the literature and research publications. This has led to the need to capture and compile the new and current information about hematologic cancer with special emphasis on translation from molecular pathobiology to targeted therapeutics. In this book experts from around the world share their thoughts and knowledge about the pathobiology of hematologic cancer, as well as their view on current treatment approaches and future development in these malignant hematologic diseases. This book is well suited for hematology residents, fellows and hematology-oncology physicians, hematopathologist as well as basic research scientist in the area of hematologic malignancies. .

Paraneoplastic syndromes. --- Lymphoproliferative disorders --- Hematologic Diseases --- Neoplasms by Site --- Neoplasms --- Hemic and Lymphatic Diseases --- Diseases --- Hematologic Neoplasms --- Medicine --- Health & Biological Sciences --- Oncology --- Internal Medicine --- Blood --- Cancer --- Treatment. --- Cancer therapy --- Cancer treatment --- Therapy --- Medicine. --- Cancer research. --- Laboratory medicine. --- Molecular biology. --- Hematology. --- Cell biology. --- Apoptosis. --- Biomedicine. --- Cancer Research. --- Laboratory Medicine. --- Molecular Medicine. --- Cell Biology. --- Cell death --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Haematology --- Internal medicine --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Clinical medicine --- Clinical pathology --- Diagnostic laboratory tests --- Laboratory diagnosis --- Laboratory medicine --- Medical laboratory diagnosis --- Diagnosis --- Pathology --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Body fluids --- Fear of blood --- Oncology. --- Medical laboratories. --- Cytology. --- Tumors --- Diagnosis, Laboratory --- Health facilities --- Laboratories --- Health Workforce