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The rheology of dense red blood cell suspensions is investigated via computer simulations based on the lattice Boltzmann, the immersed boundary, and the finite element methods. The red blood cells are treated as extended and deformable particles immersed in the ambient fluid. In the first part of the work, the numerical model and strategies for stress evaluation are discussed. In the second part, the behavior of the suspensions in simple shear flow is studied for different volume fractions, particle deformabilities, and shear rates. Shear thinning behavior is recovered. The existence of a shear-induced transition from a tumbling to a tank-treading motion is demonstrated. The transition can be parameterized by a single quantity, namely the effective capillary number. It is the ratio of the suspension stress and the characteristic particle membrane stress. At the transition point, a strong increase in the orientational order of the red blood cells and a significant decrease of the particle diffusivity are observed. However, the average cell deformation shows no signature of the transition.
Biomedical materials. --- Blood -- Transfusion. --- Blood plasma. --- Blood platelets -- Transfusion. --- Physics --- Physical Sciences & Mathematics --- Physics - General --- Blood --- Hemodynamics. --- Rheology --- Computer simulation. --- Physics. --- Physics, general. --- Cardiac output --- Hydrodynamics --- Body fluids --- Fear of blood --- Circulation --- Natural philosophy --- Philosophy, Natural --- Physical sciences --- Dynamics
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Antiplatelet therapy is the cornerstone of treatment of ischemic cardiovascular disease and over the last few years spectacular advancements in this field have been recorded. This is the first comprehensive handbook entirely dedicated to all the aspects of antiplatelet therapy. The book is divided into three main sections, pathophysiology, pharmacology and therapy, for a total of 23 chapters. A large group of leading experts from different European countries and from the USA, both from academia and industry, have contributed to the book. Besides a detailed overview on the pharmacology and clinical applications of all the currently used or of the novel antiplatelet agents, innovative approaches (e.g. intracellular signalling as an antiplatelet target, small RNAs as platelet therapeutics, etc.) or unconventional aspects (e.g. pharmacologic modulation of the inflammatory action of platelets are also treated. The book is oriented to both basic investigators and to clinicians involved with research on platelet inhibition or with the clinical use of antiplatelet therapies.
Medicine. --- Molecular biology. --- Pharmacology. --- Internal medicine. --- Cardiology. --- Neurology. --- Biomedicine. --- Pharmacology/Toxicology. --- Internal Medicine. --- Molecular Medicine. --- Medicine --- Nervous system --- Neuropsychiatry --- Heart --- Internal medicine --- Medicine, Internal --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Diseases --- Physiological effect --- Blood platelets --- Cardiovascular system --- Aggregation. --- Diseases. --- Cardiovascular diseases --- Adhesiveness, Blood platelet --- Aggregation, Blood platelet --- Blood platelet aggregation --- Platelet adhesiveness --- Platelet aggregation --- Cell aggregation --- Toxicology. --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Health Workforce --- Neurology .
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